Outputs (2373)

Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex (2005)
Journal Article
Marei, A., Ghaemmaghami, A., Renshaw, P., Wiselka, M., Barer, M., Carr, M., & Ziegler-Heitbrock, L. (2005). Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex. International Immunology, 17(11), 1439-1446. https://doi.org/10.1093/intimm/dxh322

Using intracellular cytokine staining we show herein that T cells will respond to short-term (6 h) activation with phorbol ester plus ionomycin by production of tumor necrosis factor (TNF), IFN-γ or both. Here CD4 T cells preferentially produce TNF a... Read More about Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex.

The evolution of imperfect mimicry (2005)
Book Chapter
Gilbert, F. (2005). The evolution of imperfect mimicry. In M. Fellowes, G. Holloway, & J. Rolff (Eds.), Insect Evolutionary Ecology: Proceedings Of The Royal Entomological Society's 22nd Symposium, Reading, UK, 2003 (231-288). CABI

Ideas about the evolution of imperfect mimicry are reviewed. Their relevance to the colours patterns of hoverflies (Diptera, Syrphidae) are discussed in detail.

Most if not all of the hoverflies labelled as mimetic actually are mimics. The apparent... Read More about The evolution of imperfect mimicry.

Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein (2005)
Journal Article
Owsianka, A., Tarr, A. W., Juttla, V. S., Lavillette, D., Bartosch, B., Cosset, F. L., …Patel, A. H. (2005). Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein. Journal of Virology, 79(17), 11095-11104. https://doi.org/10.1128/JVI.79.17.11095-11104.2005

Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines. Here, we describe the generation of retrovirus-based p... Read More about Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein.

Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets (2005)
Journal Article
Yamada, E., Montoya, M., Schuettler, C. G., Hickling, T. P., Tarr, A. W., Vitelli, A., …Borrow, P. (2005). Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets. Journal of General Virology, 86(9), 2507-2512. https://doi.org/10.1099/vir.0.81169-0

Hepatitis C virus (HCV) binding to hepatocytes is thought to be mediated via interaction of the E2 glycoprotein with (co-)receptors including CD81 and scavenger receptor class B type I (SR-BI). Here, the expression of CD81 and SR-BI was analysed on p... Read More about Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets.

Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection (2005)
Journal Article
Brown, R. J., Juttla, V. S., Tarr, A. W., Finnis, R., Irving, W. L., Hemsley, S., …Ball, J. K. (2005). Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection. Journal of General Virology, 86(7), 1931-1942. https://doi.org/10.1099/vir.0.80957-0

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are important targets for the host immune response. The genes encoding these proteins exhibit a high degree of variability that gives rise to differing phenotypic traits, including alterations... Read More about Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection.

A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening (2005)
Journal Article
De Bank, P. A., Kendall, D. A., & Alexander, S. P. (2005). A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. Biochemical Pharmacology, 69(8), 1187-1193. https://doi.org/10.1016/j.bcp.2005.01.012

Signalling via the endocannabinoids anandamide and 2-arachidonylglycerol appears to be terminated largely through the action of the enzyme fatty acid amide hydrolase (FAAH). In this report, we describe a simple spectrophotometric assay to detect FAAH... Read More about A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening.

Medium-term temporal stability of the helminth component community structure in bank voles (Clethrionomys glareolus) from the Mazury Lake District region of Poland (2005)
Journal Article
Bajer, A., Behnke, J. M., Pawelczyk, A., Kulis, K., Sereda, M. J., & Sinski, E. (2005). Medium-term temporal stability of the helminth component community structure in bank voles (Clethrionomys glareolus) from the Mazury Lake District region of Poland. Parasitology, 130(2), https://doi.org/10.1017/S0031182004006389

The structure of helminth communities in wild rodents is subject to seasonal variation, and is dependent on host age within years. Although between-year variation has been monitored, seldom has it been assessed rigorously by appropriate multifactoria... Read More about Medium-term temporal stability of the helminth component community structure in bank voles (Clethrionomys glareolus) from the Mazury Lake District region of Poland.

Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus (2005)
Journal Article
Lavillette, D., Tarr, A. W., Voisset, C., Donot, P., Bartosch, B., Bain, C., …Cosset, F. L. (2005). Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus. Hepatology, 41(2), 265-274. https://doi.org/10.1002/hep.20542

Because of the lack of a robust cell culture system, relatively little is known about the molecular details of the cell entry mechanism for hepatitis C virus (HCV). Recently, we described infectious HCV pseudo-particles (HCVpp) that were generated by... Read More about Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus.

Tagged polymerase chain reaction subtractive hybridization for the enrichment of phage display random peptide libraries (2005)
Journal Article
Tarr, A. W., Boneham, S. P., Grabowska, A. M., & Ball, J. K. (2005). Tagged polymerase chain reaction subtractive hybridization for the enrichment of phage display random peptide libraries. Analytical Biochemistry, 339(1), 61-68. https://doi.org/10.1016/j.ab.2004.12.020

Affinity selection of phage display peptide libraries is routinely used for isolating peptides capable of binding a range of molecules, including antibodies and receptors. This process is most successful when the selecting molecule is relatively pure... Read More about Tagged polymerase chain reaction subtractive hybridization for the enrichment of phage display random peptide libraries.

Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro (2005)
Journal Article
Stepek, G., Buttle, D. J., Duce, I., Lowe, A., & Behnke, J. M. (2005). Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro. Parasitology, 130(2), https://doi.org/10.1017/S0031182004006225

We examined the mechanism of action and compared the anthelmintic efficacy of cysteine proteinases from papaya, pineapple, fig, kiwi fruit and Egyptian milkweed in vitro using the rodent gastrointestinal nematode Heligmosomoides polygyrus. Within a 2... Read More about Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro.