Outputs (184)

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse (2022)
Journal Article
Richardson, A., Ciampani, V., Stancu, M., Bondarenko, K., Newton, S., Steinert, J. R., …Forsythe, I. D. (2022). Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse. eLife, 11, Article e75219. https://doi.org/10.7554/eLife.75219

Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four Kv3 gene family members, Kv3.1 and Kv3.3 are highly expressed in the auditory brainstem and we exploited thi... Read More about Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse.

Testing bats in rehabilitation for SARS-CoV-2 before release into the wild (2022)
Journal Article
Jones, S., Bell, T., Coleman, C. M., Harris, D., Woodward, G., Worledge, L., Roberts, H., McElhinney, L., Aegerter, J., Ransome, E., & Savolainen, V. (2022). Testing bats in rehabilitation for SARS-CoV-2 before release into the wild. Conservation Science and Practice, 4(7), Article e12707. https://doi.org/10.1111/csp2.12707

Several studies have suggested SARS-CoV-2 originated from a viral ancestor in bats, but whether transmission occurred directly or via an intermediary host to humans remains unknown. Concerns of spillover of SARS-CoV-2 into wild bat populations are hi... Read More about Testing bats in rehabilitation for SARS-CoV-2 before release into the wild.

A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications (2022)
Journal Article
Pearcy, N., Garavaglia, M., Millat, T., Gilbert, J. P., Song, Y., Hartman, H., …Minton, N. P. (2022). A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications. PLoS Computational Biology, 18(5), Article e1010106. https://doi.org/10.1371/journal.pcbi.1010106

Exploiting biological processes to recycle renewable carbon into high value platform chemicals provides a sustainable and greener alternative to current reliance on petrochemicals. In this regard Cupriavidus necator H16 represents a particularly prom... Read More about A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications.

Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review (2022)
Journal Article
Al-Nasser, M. N., Mellor, I. R., & Carter, W. G. (2022). Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review. Brain Sciences, 12(5), Article 577. https://doi.org/10.3390/brainsci12050577

L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu has been linked to neurotoxicity and neurodegeneration. To investig... Read More about Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review.

Utilising micron scale 3D printed morphologies for particle adhesion reduction (2022)
Journal Article
Marsh, G. E., Bunker, M. J., Alexander, M. R., Wildman, R. D., Nicholas, M., & Roberts, C. J. (2022). Utilising micron scale 3D printed morphologies for particle adhesion reduction. Powder Technology, 404, Article 117418. https://doi.org/10.1016/j.powtec.2022.117418

In the pharmaceutical industry, the ability to improve the understanding of the effect of surface roughness on interparticulate interactions is critical. Dry powder inhalers often possess poor efficiency, as the powder formulations are inherently adh... Read More about Utilising micron scale 3D printed morphologies for particle adhesion reduction.

Characterisation of ascocorynin biosynthesis in the purple jellydisc fungus Ascocoryne sarcoides (2022)
Journal Article
Wieder, C., Peres da Silva, R., Witts, J., Jaeger, C. M., Geib, E., & Brock, M. (2022). Characterisation of ascocorynin biosynthesis in the purple jellydisc fungus Ascocoryne sarcoides. Fungal Biology and Biotechnology, 9, Article 8. https://doi.org/10.1186/s40694-022-00138-7

Background: Non-ribosomal peptide synthetase-like (NRPS-like) enzymes are highly enriched in fungal genomes and can be discriminated into reducing and non-reducing enzymes. Non-reducing NRPS-like enzymes possess a C-terminal thioesterase domain that... Read More about Characterisation of ascocorynin biosynthesis in the purple jellydisc fungus Ascocoryne sarcoides.

Discovery of Natural Products With Antifungal Potential Through Combinatorial Synergy (2022)
Journal Article
Augostine, C. R., & Avery, S. V. (2022). Discovery of Natural Products With Antifungal Potential Through Combinatorial Synergy. Frontiers in Microbiology, 13, Article 866840. https://doi.org/10.3389/fmicb.2022.866840

The growing prevalence of antifungal drug resistance coupled with the slow development of new, acceptable drugs and fungicides has raised interest in natural products (NPs) for their therapeutic potential and level of acceptability. However, a number... Read More about Discovery of Natural Products With Antifungal Potential Through Combinatorial Synergy.

Functionalized Gold Nanoparticles with a Cohesion Enhancer for Robust Flexible Electrodes (2022)
Journal Article
Im, J., Trindade, G. F., Quach, T. T., Sohaib, A., Wang, F., Austin, J., …Tuck, C. (2022). Functionalized Gold Nanoparticles with a Cohesion Enhancer for Robust Flexible Electrodes. ACS Applied Nano Materials, 5(5), 6708-6716. https://doi.org/10.1021/acsanm.2c00742

The development of conductive inks is required to enable additive manufacturing of electronic components and devices. A gold nanoparticle (AuNP) ink is of particular interest due to its high electrical conductivity, chemical stability, and biocompati... Read More about Functionalized Gold Nanoparticles with a Cohesion Enhancer for Robust Flexible Electrodes.

The Role of Lipids in Allergic Sensitization: A Systematic Review (2022)
Journal Article
Hopkins, G. V., Cochrane, S., Onion, D., & Fairclough, L. C. (2022). The Role of Lipids in Allergic Sensitization: A Systematic Review. Frontiers in Molecular Biosciences, 9, Article 832330. https://doi.org/10.3389/fmolb.2022.832330

Background: Immunoglobulin E (IgE)-mediated allergies are increasing in prevalence, with IgE-mediated food allergies currently affecting up to 10% of children and 6% of adults worldwide. The mechanisms underpinning the first phase of IgE-mediated all... Read More about The Role of Lipids in Allergic Sensitization: A Systematic Review.

Non‐canonical endogenous expression of voltage‐gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell line (2022)
Journal Article
Aziz, M. Y., Mohammed Latif, L., Ngum, N. M., Aziz, M. Y. A., Latif, M. L., Wall, R. J., …Mellor, I. R. (2022). Non‐canonical endogenous expression of voltage‐gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell line. Journal of Physiology, 600(10), 2499-2513. https://doi.org/10.1113/JP283055

Abstract: The human TE671 cell line was originally used as a model of medulloblastoma but has since been reassigned as rhabdomyosarcoma. Despite the characterised endogenous expression of voltage-sensitive sodium currents in these cells, the specific... Read More about Non‐canonical endogenous expression of voltage‐gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell line.