Outputs (188)

The impaired quorum sensing response of Pseudomonas aeruginosa MexAB-OprM efflux pump overexpressing mutants is not due to non-physiological efflux of 3-oxo-C12-HSL (2020)
Journal Article
Alcalde‐Rico, M., Olivares‐Pacheco, J., Halliday, N., Cámara, M., & Martínez, J. L. (2020). The impaired quorum sensing response of Pseudomonas aeruginosa MexAB-OprM efflux pump overexpressing mutants is not due to non-physiological efflux of 3-oxo-C12-HSL. Environmental Microbiology, 22(12), 5167-5188. https://doi.org/10.1111/1462-2920.15177

Multidrug (MDR) efflux pumps are ancient and conserved molecular machineries with relevant roles in different aspects of the bacterial physiology, besides antibiotic resistance. In the case of the environmental opportunistic pathogen Pseudomonas aeru... Read More about The impaired quorum sensing response of Pseudomonas aeruginosa MexAB-OprM efflux pump overexpressing mutants is not due to non-physiological efflux of 3-oxo-C12-HSL.

Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity (2020)
Journal Article
Fazel, M. F., Abu, I. F., Mohamad, M. H. N., Agarwal, R., Iezhitsa, I., Bakar, N. S., …Franzyk, H. (2020). Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity. PLoS ONE, 15(7), Article e0236450. https://doi.org/10.1371/journal.pone.0236450

Retinal ganglion cell (RGC) loss and optic neuropathy, both hallmarks of glaucoma, have been shown to involve N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity. This study investigated the neuroprotective effects of Philanthotoxin (PhTX)-... Read More about Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity.

The clinical usefulness of muscle mass and strength measures in older people: a systematic review (2020)
Journal Article
Lunt, E., Ong, T., Gordon, A. L., Greenhaff, P. L., & Gladman, J. R. F. (2021). The clinical usefulness of muscle mass and strength measures in older people: a systematic review. Age and Ageing, 50(1), 88-95. https://doi.org/10.1093/ageing/afaa123

Background: Sarcopenia is the loss of muscle mass and quality and is diagnosed using measures of muscle strength, size and mass. We evaluated the literature on whether sarcopenia measures are predictive of motor outcomes in older people in clinical... Read More about The clinical usefulness of muscle mass and strength measures in older people: a systematic review.

aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis (2020)
Journal Article
Fan, R., Papatheodoridis, G., Sun, J., Innes, H., Toyoda, H., Xie, Q., …Hou, J. (2020). aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis. Journal of Hepatology, 73(6), 1368-1378. https://doi.org/10.1016/j.jhep.2020.07.025

© 2020 European Association for the Study of the Liver Background & Aims: Hepatocellular carcinoma (HCC) is the leading cause of death in patients with chronic hepatitis. In this international collaboration, we sought to develop a global universal HC... Read More about aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis.

A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29 (2020)
Journal Article
Alexander, S. P., Armstrong, J., Davenport, A., Davies, J. A., Faccenda, E., Harding, S. D., …Spedding, M. (2020). A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29. British Journal of Pharmacology, 177(21), 4942-4966. https://doi.org/10.1111/bph.15094

This article is protected by copyright. All rights reserved. In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate a... Read More about A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29.

Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis (2020)
Journal Article
Aram, J., Frakich, N., Morandi, E., Alrouji, M., Samaraweera, A., Onion, D., …Constantinescu, C. S. (2020). Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis. Biomedicines, 8(7), Article 226. https://doi.org/10.3390/BIOMEDICINES8070226

© 2020 by the authors. Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis. We investi... Read More about Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis.

Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis (2020)
Journal Article
Farrugia, C., Stafford, G. P., Potempa, J., Wilkinson, R. N., Chen, Y., Murdoch, C., & Widziolek, M. (2021). Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis. FEBS Journal, 288(5), 1479-1495. https://doi.org/10.1111/febs.15486

Several studies have shown a clear association between periodontal disease and increased risk of cardiovascular disease. Porphyromonas gingivalis (Pg), a key oral pathogen, and its cell surface-expressed gingipains, induce oedema in a zebrafish larva... Read More about Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis.

Phylogenetic relationships of the carnivorous terrestrial snail family Streptaxidae (Stylommatophora: Achatinina) in Thailand and surrounding areas of Southeast Asia (2020)
Journal Article
Siriboon, T., Naggs, F., Wade, C. M., Jeratthitikul, E., Tongkerd, P., Jirapatrasilp, P., …Sutcharit, C. (2020). Phylogenetic relationships of the carnivorous terrestrial snail family Streptaxidae (Stylommatophora: Achatinina) in Thailand and surrounding areas of Southeast Asia. Systematics and Biodiversity, 18(7), 720-738. https://doi.org/10.1080/14772000.2020.1783384

© 2020, © The Trustees of the Natural History Museum, London 2020. All Rights Reserved. Southeast Asia boasts a high diversity of carnivorous terrestrial snails in the family Streptaxidae. Six genera are now recognized in this region, mainly classifi... Read More about Phylogenetic relationships of the carnivorous terrestrial snail family Streptaxidae (Stylommatophora: Achatinina) in Thailand and surrounding areas of Southeast Asia.

Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function (2020)
Journal Article
Atkins, R., Constantin-Teodosiu, D., Varadhan, K. K., Constantin, D., Lobo, D. N., & Greenhaff, P. L. (2021). Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function. Clinical Nutrition, 40(3), 1046-1051. https://doi.org/10.1016/j.clnu.2020.07.006

© 2020 The Author(s) Background & aims: This post hoc study aimed to determine whether major elective abdominal surgery had any acute impact on mitochondrial pyruvate dehydrogenase complex (PDC) activity and maximal mitochondrial ATP production rates... Read More about Major elective abdominal surgery acutely impairs lower limb muscle pyruvate dehydrogenase complex activity and mitochondrial function.

Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins (2020)
Journal Article
Alzahofi, N., Welz, T., Robinson, C. L., Page, E. L., Briggs, D. A., Stainthorp, A. K., …Hume, A. N. (2020). Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins. Nature Communications, 11(1), Article 3495. https://doi.org/10.1038/s41467-020-17212-6

© 2020, The Author(s). Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered... Read More about Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins.