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A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29

Alexander, Stephen P.H.; Armstrong, Jane; Davenport, Anthony; Davies, Jamie A.; Faccenda, Elena; Harding, Simon D.; Levi?Schaffer, Francesca; Maguire, Janet J.; Pawson, Adam J.; Southan, Chrstopher; Spedding, Michael


Jane Armstrong

Anthony Davenport

Jamie A. Davies

Elena Faccenda

Simon D. Harding

Francesca Levi?Schaffer

Janet J. Maguire

Adam J. Pawson

Chrstopher Southan

Michael Spedding


This article is protected by copyright. All rights reserved. In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. We assess the scope for targetting key host and viral targets in the mid-term, by first screening these targets against drugs already licensed; an agenda for drug re-purposing, which should allow rapid translation to clinical trials. A simultaneous, multi-pronged approach using conventional drug discovery methodologies aimed at discovering novel chemical and biological means targetting a short-list of host and viral entities should extend the arsenal of anti-SARS-CoV-2 agents. This longer-term strategy would provide a deeper pool of drug choices for future-proofing against acquired drug resistance. Second, there will be further viral threats, which will inevitably evade existing vaccines. This will require a coherent therapeutic strategy which pharmacology and pharmacologists are best placed to provide.


Alexander, S. P., Armstrong, J., Davenport, A., Davies, J. A., Faccenda, E., Harding, S. D., …Spedding, M. (2020). A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29. British Journal of Pharmacology, 177(21), 4942-4966.

Journal Article Type Review
Acceptance Date Apr 28, 2020
Online Publication Date Jul 19, 2020
Publication Date 2020-11
Deposit Date Jul 18, 2020
Publicly Available Date Jul 20, 2020
Journal British Journal of Pharmacology
Print ISSN 0007-1188
Electronic ISSN 1476-5381
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 177
Issue 21
Pages 4942-4966
Keywords Pharmacology
Public URL
Publisher URL


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