A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29

Alexander, Stephen P.H.; Armstrong, Jane; Davenport, Anthony; Davies, Jamie A.; Faccenda, Elena; Harding, Simon D.; Levi?Schaffer, Francesca; Maguire, Janet J.; Pawson, Adam J.; Southan, Chrstopher; Spedding, Michael

Abstract

This article is protected by copyright. All rights reserved. In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. We assess the scope for targetting key host and viral targets in the mid-term, by first screening these targets against drugs already licensed; an agenda for drug re-purposing, which should allow rapid translation to clinical trials. A simultaneous, multi-pronged approach using conventional drug discovery methodologies aimed at discovering novel chemical and biological means targetting a short-list of host and viral entities should extend the arsenal of anti-SARS-CoV-2 agents. This longer-term strategy would provide a deeper pool of drug choices for future-proofing against acquired drug resistance. Second, there will be further viral threats, which will inevitably evade existing vaccines. This will require a coherent therapeutic strategy which pharmacology and pharmacologists are best placed to provide.

Citation

Alexander, S. P., Armstrong, J., Davenport, A., Davies, J. A., Faccenda, E., Harding, S. D., …Spedding, M. (2020). A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29. British Journal of Pharmacology, 177(21), 4942-4966. https://doi.org/10.1111/bph.15094

• Journal Article Type: Review
• Acceptance Date: Apr 28, 2020
• Online Publication Date: Jul 19, 2020
• Publication Date: 2020-11
• Deposit Date: Jul 18, 2020
• Publicly Available Date: Jul 20, 2020
• Journal: British Journal of Pharmacology
• Print ISSN: 0007-1188
• Electronic ISSN: 1476-5381
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 177
• Issue: 21
• Pages: 4942-4966
• DOI: https://doi.org/10.1111/bph.15094
• Keywords: Pharmacology
• Public URL: https://nottingham-repository.worktribe.com/output/4373221
• Publisher URL: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15094