Outputs (188)

Evidence for selection in a prokaryote pangenome (2020)
Preprint / Working Paper
Whelan, F. J., Hall, R. J., & McInerney, J. O. Evidence for selection in a prokaryote pangenome

A pangenome is the complete set of genes (core and accessory) present in a phylogenetic clade. We hypothesize that a pangenome’s accessory gene content is structured and maintained by selection. To test this hypothesis, we interrogated the genomes of... Read More about Evidence for selection in a prokaryote pangenome.

The life cycle of the Mu-Opioid Receptor (2020)
Journal Article
Cuitavi, J., Hipólito, L., & Canals, M. (2021). The life cycle of the Mu-Opioid Receptor. Trends in Biochemical Sciences, 46(4), 315-328. https://doi.org/10.1016/j.tibs.2020.10.002

Opioid receptors are undisputed targets for the treatment of pain. Unfortunately, targeting these receptors therapeutically poses significant challenges including addiction, dependence, tolerance and the appearance of side-effects such as respiratory... Read More about The life cycle of the Mu-Opioid Receptor.

STAT3-mediated astrocyte reactivity associated with brain metastasis contributes to neurovascular dysfunction (2020)
Journal Article
Sarmiento Soto, M., Larkin, J. R., Martin, C., Khrapitchev, A. A., Maczka, M., Economopoulos, V., …Sibson, N. R. (2020). STAT3-mediated astrocyte reactivity associated with brain metastasis contributes to neurovascular dysfunction. Cancer Research, 80(24), 5642-5655. https://doi.org/10.1158/0008-5472.CAN-20-2251

© 2020 American Association for Cancer Research. Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral blood flow. However, it has been shown that astrocytes undergo morphologic changes in response to brain metastasis... Read More about STAT3-mediated astrocyte reactivity associated with brain metastasis contributes to neurovascular dysfunction.

Formation and diversification of a paradigm biosynthetic gene cluster in plants (2020)
Journal Article
Liu, Z., Cheema, J., Vigouroux, M., Hill, L., Reed, J., Paajanen, P., …Osbourn, A. (2020). Formation and diversification of a paradigm biosynthetic gene cluster in plants. Nature Communications, 11(1), Article 5354. https://doi.org/10.1038/s41467-020-19153-6

© 2020, The Author(s). Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of agricultural and medicinal importance, have now been discovered in plant genomes. However, little is known about how these complex traits are as... Read More about Formation and diversification of a paradigm biosynthetic gene cluster in plants.

Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers (2020)
Journal Article
Bétry, C., Nixon, A. V., Greenhaff, P. L., & Simpson, E. J. (2022). Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers. Experimental and Clinical Endocrinology and Diabetes, 130(01), 49-54. https://doi.org/10.1055/a-1275-4038

© 2020 Lippincott Williams and Wilkins. All rights reserved. Introduction Skeletal muscle is a major site for whole-body glucose disposal, and determination of skeletal muscle glucose uptake is an important metabolic measurement, particularly in rese... Read More about Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers.

Critical assessment of G protein-biased agonism at the µ opioid receptor (2020)
Journal Article
Gillis, A., Kliewer, A., Kelly, E., Henderson, G., Christie, M. J., Schulz, S., & Canals, M. (2020). Critical assessment of G protein-biased agonism at the µ opioid receptor. Trends in Pharmacological Sciences, 41(12), 947-959. https://doi.org/10.1016/j.tips.2020.09.009

G protein-biased agonists of the µ-opioid receptor have been proposed to be an improved class of opioid analgesics. Recent studies have been unable to reproduce the original experiments in the β-arrestin2 knockout mouse that led to this proposal, and... Read More about Critical assessment of G protein-biased agonism at the µ opioid receptor.

Site‐Selective Modification of Peptides and Proteins via Interception of Free‐Radical‐Mediated Dechalcogenation (2020)
Journal Article
Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H. E. L., Layfield, R., & Mitchell, N. J. (2020). Site‐Selective Modification of Peptides and Proteins via Interception of Free‐Radical‐Mediated Dechalcogenation. Angewandte Chemie, 132(52), 23867-23875. https://doi.org/10.1002/ange.202006260

The development of site-selective chemistry targeting the canonical amino acids enables the controlled installation of desired functionalities into native peptides and proteins. Such techniques facilitate the development of polypeptide conjugates to... Read More about Site‐Selective Modification of Peptides and Proteins via Interception of Free‐Radical‐Mediated Dechalcogenation.

Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy (2020)
Journal Article
Townley, A., & Wheatley, S. P. (2020). Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy. Journal of Cell Science, 133(21), Article jcs247379. https://doi.org/10.1242/jcs.247379

Survivin is a cancer-associated protein that is pivotal for cellular life and death: it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria, the function of which rema... Read More about Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy.

Synthetic biology on acetogenic bacteria for highly efficient conversion of c1 gases to biochemicals (2020)
Journal Article
Jin, S., Bae, J., Song, Y., Pearcy, N., Shin, J., Kang, S., …Cho, B. K. (2020). Synthetic biology on acetogenic bacteria for highly efficient conversion of c1 gases to biochemicals. International Journal of Molecular Sciences, 21(20), Article 7639. https://doi.org/10.3390/ijms21207639

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Synthesis gas, which is mainly produced from fossil fuels or biomass gasification, consists of C1 gases such as carbon monoxide, carbon dioxide, and methane as well as hydrogen. Acetogenic bac... Read More about Synthetic biology on acetogenic bacteria for highly efficient conversion of c1 gases to biochemicals.

Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours (2020)
Journal Article
McCrorie, P., Mistry, J., Taresco, V., Lovato, T., Fay, M., Ward, I., …Rahman, R. (2020). Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours. European Journal of Pharmaceutics and Biopharmaceutics, 157, 108-120. https://doi.org/10.1016/j.ejpb.2020.10.005

Glioblastoma is a malignant brain tumour with a median survival of 14.6 months from diagnosis. Despite maximal surgical resection and concurrent chemoradiotherapy, reoccurrence is inevitable. To try combating the disease at a stage of low residual tu... Read More about Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours.