Synthetic biology on acetogenic bacteria for highly efficient conversion of c1 gases to biochemicals

Jin, Sangrak; Bae, Jiyun; Song, Yoseb; Pearcy, Nicole; Shin, Jongoh; Kang, Seulgi; Minton, Nigel P.; Soucaille, Philippe; Cho, Byung Kwan

doi:10.3390/ijms21207639

Synthetic biology on acetogenic bacteria for highly efficient conversion of c1 gases to biochemicals Thumbnail

Authors

Sangrak Jin

Jiyun Bae

Yoseb Song

NICOLE PEARCY Nicole.Pearcy@nottingham.ac.uk
Senior Research Fellow in Systems

Jongoh Shin

Seulgi Kang

Professor NIGEL MINTON nigel.minton@nottingham.ac.uk
Professor of Applied Molecular Microbiology

Dr PHILIPPE SOUCAILLE Philippe.Soucaille@nottingham.ac.uk
Chair in Synthetic Biology and Metabolic Engineering

Byung Kwan Cho

Abstract

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Synthesis gas, which is mainly produced from fossil fuels or biomass gasification, consists of C1 gases such as carbon monoxide, carbon dioxide, and methane as well as hydrogen. Acetogenic bacteria (acetogens) have emerged as an alternative solution to recycle C1 gases by converting them into value-added biochemicals using the Wood-Ljungdahl pathway. Despite the advantage of utilizing acetogens as biocatalysts, it is difficult to develop industrial-scale bioprocesses because of their slow growth rates and low productivities. To solve these problems, conventional approaches to metabolic engineering have been applied; however, there are several limitations owing to the lack of required genetic bioparts for regulating their metabolic pathways. Recently, synthetic biology based on genetic parts, modules, and circuit design has been actively exploited to overcome the limitations in acetogen engineering. This review covers synthetic biology applications to design and build industrial platform acetogens.

Citation

Jin, S., Bae, J., Song, Y., Pearcy, N., Shin, J., Kang, S., …Cho, B. K. (2020). Synthetic biology on acetogenic bacteria for highly efficient conversion of c1 gases to biochemicals. International Journal of Molecular Sciences, 21(20), Article 7639. https://doi.org/10.3390/ijms21207639

Journal Article Type	Article
Acceptance Date	Oct 13, 2020
Online Publication Date	Oct 15, 2020
Publication Date	Oct 15, 2020
Deposit Date	Nov 3, 2020
Publicly Available Date	Nov 3, 2020
Journal	International Journal of Molecular Sciences
Print ISSN	1661-6596
Electronic ISSN	1422-0067
Publisher	MDPI
Peer Reviewed	Peer Reviewed
Volume	21
Issue	20
Article Number	7639
DOI	https://doi.org/10.3390/ijms21207639
Keywords	Physical and Theoretical Chemistry; Inorganic Chemistry; Organic Chemistry; Spectroscopy; Molecular Biology; Catalysis; General Medicine; Computer Science Applications
Public URL	https://nottingham-repository.worktribe.com/output/4974002
Publisher URL	https://www.mdpi.com/1422-0067/21/20/7639