Outputs (212)

The application of protein microarray assays in psychoneuroimmunology (2016)
Journal Article
Ayling, K., Bowden, T., Tighe, P., Todd, I., Dilnot, E. M., Negm, O., …Vedhara, K. (2017). The application of protein microarray assays in psychoneuroimmunology. Brain, Behavior, and Immunity, 59, 62-66. https://doi.org/10.1016/j.bbi.2016.09.013

Protein microarrays are miniaturized multiplex assays that exhibit many advantages over the commonly used enzyme-linked immunosorbent assay (ELISA). This article aims to introduce protein microarrays to readers of Brain, Behavior, and Immunity and de... Read More about The application of protein microarray assays in psychoneuroimmunology.

Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation (2016)
Journal Article
Gray, S., & Cohen, P. E. (2016). Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation. Annual Review of Genetics, 50(1), 175-210. https://doi.org/10.1146/annurev-genet-120215-035111

© 2016 by Annual Reviews. All rights reserved. Meiosis, the mechanism of creating haploid gametes, is a complex cellular process observed across sexually reproducing organisms. Fundamental to meiosis is the process of homologous recombination, whereb... Read More about Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation.

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes (2016)
Journal Article
Pylypenko, O., Welz, T., Tittel, J., Kollmar, M., Chardon, F., Malherbe, G., …Kerkhoff, E. (in press). Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes. eLife, 5, Article e17523. https://doi.org/10.7554/eLife.17523

There is growing evidence for a coupling of actin assembly and myosin motor activity in cells. However, mechanisms for recruitment of actin nucleators and motors on specific membrane compartments remain unclear. Here we report how Spir actin nucleato... Read More about Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes.

The fitness burden imposed by synthesising quorum sensing signals (2016)
Journal Article
Ruparell, A., Dubern, J.-F., Ortori, C. A., Harrison, F., Halliday, N., Emtage, A., …Hardie, K. R. (2016). The fitness burden imposed by synthesising quorum sensing signals. Scientific Reports, 6, Article 33101. https://doi.org/10.1038/srep33101

It is now well established that bacterial populations utilize cell-to-cell signaling (quorum-sensing, QS) to control the production of public goods and other co-operative behaviours. Evolutionary theory predicts that both the cost of signal productio... Read More about The fitness burden imposed by synthesising quorum sensing signals.

Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion (2016)
Journal Article
Coleman, C. M., Sisk, J. M., Mingo, R. M., Nelson, E. A., White, J. M., & Frieman, M. B. (2016). Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion. Journal of Virology, 90(19), 8924-8933. https://doi.org/10.1128/jvi.01429-16

© 2016, American Society for Microbiology. All Rights Reserved. The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) cause significant morbidity and morality. There... Read More about Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion.

Assessing myxozoan presence and diversity using environmental DNA (2016)
Journal Article
Okamura, B., Hartikainen, H., Green, A. J., Bass, D., Knipe, H., & Briscoe, A. G. (2016). Assessing myxozoan presence and diversity using environmental DNA. International Journal for Parasitology, 46(12), 781-792. https://doi.org/10.1016/j.ijpara.2016.07.006

Amplicon sequencing on a High Throughput Sequencing platform (custom barcoding) was used to detect and characterise myxosporean communities in environmental DNA samples from marine and freshwater environments and in faeces of animals that may serve a... Read More about Assessing myxozoan presence and diversity using environmental DNA.

Separating chemotherapy-related developmental neurotoxicity from cytotoxicity in monolayer and neurosphere cultures of human fetal brain cells (2016)
Journal Article
Ivanov, D. P., Al-Rubai, A.-J., Grabowska, A. M., & Pratten, M. K. (2016). Separating chemotherapy-related developmental neurotoxicity from cytotoxicity in monolayer and neurosphere cultures of human fetal brain cells. Toxicology in Vitro, 37, 88-96. https://doi.org/10.1016/j.tiv.2016.09.007

Chemotherapy-induced neurotoxicity can reduce the quality of life of patients by affecting their intelligence, senses and mobility. Ten percent of safety-related late-stage clinical failures are due to neurological side effects. Animal models are poo... Read More about Separating chemotherapy-related developmental neurotoxicity from cytotoxicity in monolayer and neurosphere cultures of human fetal brain cells.

Phenological shifts in hoverflies (Diptera: Syrphidae): linking measurement and mechanism (2016)
Journal Article
Hassall, C., Owen, J., & Gilbert, F. (in press). Phenological shifts in hoverflies (Diptera: Syrphidae): linking measurement and mechanism. Ecography, 40(7), https://doi.org/10.1111/ecog.02623

An understanding of ecological and evolutionary responses to global environmental change requires both a robust measurement of the change that is occurring and a mechanistic framework for understanding the drivers of that change. Such a requirement p... Read More about Phenological shifts in hoverflies (Diptera: Syrphidae): linking measurement and mechanism.

Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models (2016)
Journal Article
Meesawatsom, P., Burston, J., Hathway, G., Bennett, A., & Chapman, V. (2016). Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. Journal of Neuroinflammation, 13, Article 233. https://doi.org/10.1186/s12974-016-0676-6

Background: Harnessing the actions of the resolvin pathways has the potential for the treatment of a wide range of conditions associated with overt inflammatory signalling. Aspirin-triggered resolvin D1 (AT-RvD1) has robust analgesic effects in behav... Read More about Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.

Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay (2016)
Journal Article
Urbanowicz, R. A., McClure, C. P., King, B., Mason, C. P., Ball, J. K., & Tarr, A. W. (2016). Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay. Journal of General Virology, 97(9), 2265-2279. https://doi.org/10.1099/jgv.0.000537

Retrovirus pseudotypes are a highly tractable model used to study the entry pathways of enveloped viruses. This model has been extensively applied to the study of the hepatitis C virus (HCV) entry pathway, pre-clinical screening of antiviral antibodi... Read More about Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay.