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Outputs (22)

Method for RNA extraction and transcriptomic analysis of single fungal spores (2019)
Journal Article
Geoghegan, I. A., Emes, R. D., Archer, D. B., & Avery, S. V. (2020). Method for RNA extraction and transcriptomic analysis of single fungal spores. MethodsX, 7, 50-55. https://doi.org/10.1016/j.mex.2019.12.002

Transcriptomic analysis of single cells has been increasingly in demand in recent years, thanks to technological and methodological advances as well as growing recognition of the importance of individuals in biological systems. However, the majority... Read More about Method for RNA extraction and transcriptomic analysis of single fungal spores.

Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo (2019)
Journal Article
Faidra Angelerou, M. G., Markus, R., Paraskevopoulou, V., Foralosso, R., Clarke, P., Alvarez, C. V., Chenlo, M., Johnson, L., Rutland, C., Allen, S., Brasnett, C., Seddon, A., Zelzer, M., & Marlow, M. (2020). Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo. Journal of Controlled Release, 317, 118-129. https://doi.org/10.1016/j.jconrel.2019.10.011

Supramolecular gels have recently emerged as promising biomaterials for the delivery of a wide range of bioactive molecules, from small hydrophobic drugs to large biomolecules such as proteins. Although it has been demonstrated that each encapsulated... Read More about Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo.

Re-evaluation of the pharmacokinetics of xylazine administered to Thoroughbred horses (2019)
Journal Article
Habershon‐Butcher, J., Cutler, C., Viljanto, M., Hincks, P. R., Biddle, S., & Paine, S. W. (2020). Re-evaluation of the pharmacokinetics of xylazine administered to Thoroughbred horses. Journal of Veterinary Pharmacology and Therapeutics, 43(1), 6-12. https://doi.org/10.1111/jvp.12820

© 2019 John Wiley & Sons Ltd Xylazine is widely used worldwide as a short-acting sedative in general equine and racing practice. In the UK, although it has a legitimate use during training, equine anti-doping rules state it is a prohibited substanc... Read More about Re-evaluation of the pharmacokinetics of xylazine administered to Thoroughbred horses.

Assessment of costs and insurance policies for referral treatment of equine colic (2019)
Journal Article
Barker, I., & Freeman, S. L. (2019). Assessment of costs and insurance policies for referral treatment of equine colic. Veterinary Record, 185(16), 1-6. https://doi.org/10.1136/vr.105415

Colic is the most common emergency problem in horses. The aims of this study were to survey costs of different referral treatments and to review insurance policies relevant to horses with colic. Data were collected retrospectively from nine equine ho... Read More about Assessment of costs and insurance policies for referral treatment of equine colic.

Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial-Mesenchymal Transition (2019)
Journal Article
Kletukhina, S., Neustroeva, O., James, V., Rizvanov, A., & Gomzikova, M. (2019). Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial-Mesenchymal Transition. International Journal of Molecular Sciences, 20(19), Article 4813. https://doi.org/10.3390/ijms20194813

Epithelial-mesenchymal transition (EMT) is a process that takes place during embryonic development, wound healing, and under some pathological processes, including fibrosis and tumor progression. The molecular changes occurring within epithelial cell... Read More about Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial-Mesenchymal Transition.

Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge (2019)
Journal Article
Clarkson, A., Paine, S., Martín-Tereso, J., & Kendall, N. (2020). Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge. Nutrition Research Reviews, 33(1), 43-49. https://doi.org/10.1017/S0954422419000180

Ruminants are recognised to suffer from Cu-responsive disorders. Present understanding of Cu transport and metabolism is limited and inconsistent across vets and veterinary professionals. There has been much progress from the studies of the 1980s and... Read More about Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge.

Cross-sectional study of horse owners’ knowledge, and opinions on recognising colic in the horse (2019)
Journal Article
Bowden, A., Burford, J., Brennan, M., England, G., & Freeman, S. (2019). Cross-sectional study of horse owners’ knowledge, and opinions on recognising colic in the horse. Equine Veterinary Journal, https://doi.org/10.1111/evj.13173

Background
Colic is the most common emergency problem in the horse. An owner’s ability to recognise colic and seek assistance is a critical first step in determining case outcome.

Objectives
The aim of this study was to assess horse owners’ know... Read More about Cross-sectional study of horse owners’ knowledge, and opinions on recognising colic in the horse.

Key concepts for making informed choices (2019)
Journal Article
Aronson, J. K., Barends, E., Boruch, R., Brennan, M., Chalmers, I., Chislett, J., Cunliffe-Jones, P., Dahlgren, A., Gaarder, M., Haines, A., Heneghan, C., Matthews, R., Maynard, B., Oxman, A. D., Oxman, M., Pullin, A., Randall, N., Roddam, H., Schoonees, A., Sharples, J., …Vale, L. (2019). Key concepts for making informed choices. Nature, 572(7769), 303-306. https://doi.org/10.1038/d41586-019-02407-9

An alliance of researchers lays out a framework for taking decisions based on thinking critically about claims and comparisons. Everyone makes claims about what works. Politicians claim that stop and search will reduce violent crime; friends claim th... Read More about Key concepts for making informed choices.

The multitasking Fasciola gigantica Cathepsin B interferes with various functions of goat peripheral blood mononuclear cells in vitro (2019)
Journal Article
Chen, D., Tian, A.-L., Hou, J.-L., Li, J.-X., Tian, X., Yuan, X.-D., Li, X., Elsheikha, H. M., & Zhu, X.-Q. (2019). The multitasking Fasciola gigantica Cathepsin B interferes with various functions of goat peripheral blood mononuclear cells in vitro. Frontiers in Immunology, 10, Article 1707. https://doi.org/10.3389/fimmu.2019.01707

Cathepsin B, a lysosomal cysteine protease, is thought to be involved in the pathogenesis of Fasciola gigantica infection, but its exact role remains unclear. In the present study, a recombinant F. gigantica cathepsin B (rFgCatB) protein was expresse... Read More about The multitasking Fasciola gigantica Cathepsin B interferes with various functions of goat peripheral blood mononuclear cells in vitro.