Outputs (22)

Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers (2014)
Journal Article
Pimpão, R. C., Dew, T., Figueira, M. E., McDougall, G. J., Stewart, D., Ferreira, R. B., Santos, C. N., & Williamson, G. (2014). Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers. Molecular Nutrition and Food Research, 58(7), 1414-1425. https://doi.org/10.1002/mnfr.201300822

Scope
The colonic metabolism of dietary flavonoids, phenolic acids and their phenolic metabolites is complex and many metabolites and conjugates have not yet been unambiguously identified in humans.

Methods and results
Urine samples from nine he... Read More about Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers.

Tobacco smoking and excess mortality in multiple sclerosis: a cohort study (2014)
Journal Article
Constantinescu, C. S., Britton, J., Manouchehrinia, A., CONSTANTINESCU, C., Weston, M., & Tench, C. R. (2014). Tobacco smoking and excess mortality in multiple sclerosis: a cohort study. Journal of Neurology, Neurosurgery and Psychiatry, 85(10), 1091-1095. https://doi.org/10.1136/jnnp-2013-307187

Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review (2013)
Journal Article
Dew, T. P., & Williamson, G. (2013). Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review. Menopause, 20(11), 1207-1215. https://doi.org/10.1097/gme.0b013e3182896ae5

Concerns regarding hormone therapy safety have led to interest in the use of phytoestrogens for a variety of menopause-related health complaints. Recent meta-analyses concerning soy and postmenopausal bone mineral density, flax and serum cholesterol... Read More about Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review.

Analysis of Phenolic Compounds in Portuguese Wild and Commercial Berries after Multienzyme Hydrolysis (2013)
Journal Article
Pimpão, R. C., Dew, T., Oliveira, P. B., Williamson, G., Ferreira, R. B., & Santos, C. N. (2013). Analysis of Phenolic Compounds in Portuguese Wild and Commercial Berries after Multienzyme Hydrolysis. Journal of Agricultural and Food Chemistry, 61(17), 4053-4062. https://doi.org/10.1021/jf305498j

Berry fruits are a good source of phenolic compounds and thus, potentially beneficial to health. Phenolic compounds are mainly present as a variety of conjugated forms, either with sugars via O-glycosidic bonds or with other polyols as esters. This c... Read More about Analysis of Phenolic Compounds in Portuguese Wild and Commercial Berries after Multienzyme Hydrolysis.

Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid (2013)
Journal Article
Rhodes, L. E., Darby, G., Massey, K. A., Clarke, K. A., Dew, T. P., Farrar, M. D., Bennett, S., Watson, R. E. B., Williamson, G., & Nicolaou, A. (2013). Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid. British Journal of Nutrition, 110(5), 891-900. https://doi.org/10.1017/s0007114512006071

Green tea catechins (GTC) reduce UV radiation (UVR)-induced inflammation in experimental models, but human studies are scarce and their cutaneous bioavailability and mechanism of photoprotection are unknown. We aimed to examine oral GTC cutaneous upt... Read More about Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid.

Predicting Phenolic Acid Absorption in Caco-2 Cells: A Theoretical Permeability Model and Mechanistic Study (2011)
Journal Article
Farrell, T. L., Poquet, L., Dew, T. P., Barber, S., & Williamson, G. (2012). Predicting Phenolic Acid Absorption in Caco-2 Cells: A Theoretical Permeability Model and Mechanistic Study. Drug Metabolism and Disposition, 40(2), 397-406. https://doi.org/10.1124/dmd.111.041665

There is a considerable need to rationalize the membrane permeability and mechanism of transport for potential nutraceuticals. The aim of this investigation was to develop a theoretical permeability equation, based on a reported descriptive absorptio... Read More about Predicting Phenolic Acid Absorption in Caco-2 Cells: A Theoretical Permeability Model and Mechanistic Study.

Absorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial Monolayers (2011)
Journal Article
Farrell, T. L., Dew, T. P., Poquet, L., Hanson, P., & Williamson, G. (2011). Absorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial Monolayers. Drug Metabolism and Disposition, 39(12), 2338-2346. https://doi.org/10.1124/dmd.111.040147

Gastric absorption of feruloylquinic acid and di-O-caffeoylquinic acid analogs has never been investigated despite their potential contribution to the proposed beneficial health effects leading to reduced risk of type 2 diabetes. Using a cultured gas... Read More about Absorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial Monolayers.

Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials (2011)
Journal Article
Williamson, G., Coppens, P., Serra-Majem, L., & Dew, T. (2011). Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials. Food and Function, 2(12), 753-759. https://doi.org/10.1039/c1fo10101c

We assess the evidence for health benefits of three commonly consumed plant food supplements (PFS), green tea, isoflavone and aloe vera, based on published systematic reviews of randomised controlled trials (RCTs). Whilst the potential benefits of gr... Read More about Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials.

Influence of Combined Biotic and Abiotic Stress on Nutritional Quality Parameters in Tomato (Solanum lycopersicum) (2011)
Journal Article
Atkinson, N. J., Dew, T. P., Orfila, C., & Urwin, P. E. (2011). Influence of Combined Biotic and Abiotic Stress on Nutritional Quality Parameters in Tomato (Solanum lycopersicum). Journal of Agricultural and Food Chemistry, 59(17), 9673-9682. https://doi.org/10.1021/jf202081t

Induction of abiotic stress in tomato plants has been proposed as a mechanism for improving the nutritional quality of fruits. However, the occurrence of biotic stress can interfere with normal abiotic stress responses. In this study, the combined ef... Read More about Influence of Combined Biotic and Abiotic Stress on Nutritional Quality Parameters in Tomato (Solanum lycopersicum).

Epigallocatechin-3-gallate Inhibits Lactase but Is Alleviated by Salivary Proline-Rich Proteins (2011)
Journal Article
Naz, S., Siddiqi, R., Dew, T. P., & Williamson, G. (2011). Epigallocatechin-3-gallate Inhibits Lactase but Is Alleviated by Salivary Proline-Rich Proteins. Journal of Agricultural and Food Chemistry, 59(6), 2734-2738. https://doi.org/10.1021/jf103072z

Lactase phlorizin hydrolase is a small intestinal brush border enzyme that catalyzes the hydrolysis of the milk sugar, lactose, and also many flavonoid glucosides. We demonstrate that epigallocatechin-3-gallate (EGCG), the principal flavonoid from gr... Read More about Epigallocatechin-3-gallate Inhibits Lactase but Is Alleviated by Salivary Proline-Rich Proteins.