Outputs (91)
Prevalence and distributions of severely elevated low-density lipoprotein cholesterol (LDL-c) according to age, gender and clinic location among patients in the Malaysian primary care (2024)
Journal Article
Background Adults with severely elevated low-density lipoprotein cholesterol (LDL-c) may have familial hypercholesterolaemia (FH) and are at high risk of atherosclerotic cardiovascular disease (ASCVD). The prevalence of elevated LDL-c in primary car... Read More about Prevalence and distributions of severely elevated low-density lipoprotein cholesterol (LDL-c) according to age, gender and clinic location among patients in the Malaysian primary care.
A case report of heterozygous familial hypercholesterolaemia with LDLR gene mutation complicated by premature coronary artery disease detected in primary care (2024)
Journal Article
Background: Familial hypercholesterolaemia (FH) is an autosomal dominant genetic condition predominantly caused by the low-density lipoprotein receptor (LDLR) gene mutation. Case summary: This is the case of a 54-year-old Malay woman with genetically... Read More about A case report of heterozygous familial hypercholesterolaemia with LDLR gene mutation complicated by premature coronary artery disease detected in primary care.
Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective (2024)
Journal Article
Introduction Allopurinol, the first-line treatment for chronic gout, is a common causative drug for severe cutaneous adverse reactions (SCAR). HLA-B*58:01 allele was strongly associated with allopurinol-induced SCAR in Asian countries such as Taiwan,... Read More about Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective.
Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021) (2023)
Journal Article
Cardiovascular disease (CVD) is the leading cause of death worldwide. Hypercholesterolaemia, especially higher low-density lipoprotein cholesterol (LDL-c), has been recognised as one of the major key risk factors for CVD. Lipid lowering treatments, s... Read More about Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021).
Assessment of ethnic inequalities in diagnostic coding of familial hypercholesterolaemia (FH): A cross-sectional database study in Lambeth, South London (2023)
Journal Article
Background and aims: Differences in the perceived prevalence of familial hypercholesterolemia (FH) by ethnicity are unclear. In this study, we aimed to assess the prevalence, determinants and management of diagnostically-coded FH in an ethnically div... Read More about Assessment of ethnic inequalities in diagnostic coding of familial hypercholesterolaemia (FH): A cross-sectional database study in Lambeth, South London.
Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis (2023)
Journal Article
Background Cascade testing the relatives of people with familial hypercholesterolaemia is an efficient approach to identifying familial hypercholesterolaemia. The cascade-testing protocol starts with identifying an index patient with familial hyperc... Read More about Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis.
A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach (2023)
Journal Article
Individuals developing stroke have varying clinical characteristics, demographic, and biochemical profiles. This heterogeneity in phenotypic characteristics can impact on cardiovascular disease (CVD) morbidity and mortality outcomes. This study uses... Read More about A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach.
Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE) (2023)
Journal Article
Purpose To investigate the longitudinal associations between pain and depressive symptoms in adults. Methods Prospective cohort study on data from 28,515 community-dwelling adults ≥ 50 years, free from depression at baseline (Wave 5), with follo... Read More about Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).
UK research data resources based on primary care electronic health records: review and summary for potential users (2023)
Journal Article
Objectives To describe the current landscape of UK electronic health record (EHR) databases and considerations of access and use of these resources relevant to researchers. Design & setting Narrative review Data sources Information was collecte... Read More about UK research data resources based on primary care electronic health records: review and summary for potential users.
BACKGROUND: Risk stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) could provide a better balance of benefits and harms. We developed BC-Predict, to offer women when invited to the NHSBSP, which collects standard risk fa... Read More about Correction To: Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420).
The role of knowledge, primary care and community engagement to improve breast-screening access for Pakistani women in the United Kingdom: A secondary analysis of a qualitative study (2023)
Journal Article
Objective Breast cancer incidence is rising among Pakistani women in the United Kingdom. However, uptake of breast screening remains low. This study aimed to improve access to breast screening for British-Pakistani women by exploring their knowledge... Read More about The role of knowledge, primary care and community engagement to improve breast-screening access for Pakistani women in the United Kingdom: A secondary analysis of a qualitative study.
Background: Familial hypercholesterolemia (FH) is predominantly caused by mutations in the 4 FH candidate genes (FHCGs), namely, low-density lipoprotein receptor (LDLR), apolipoprotein B-100 (APOB-100), proprotein convertase subtilisin/kexin type 9 (... Read More about Reducing Premature Coronary Artery Disease in Malaysia by Early Identification of Familial Hypercholesterolemia Using the Familial Hypercholesterolemia Case Ascertainment Tool (FAMCAT): Protocol for a Mixed Methods Evaluation Study.
Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420) (2023)
Journal Article
Background Risk stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) could provide a better balance of benefits and harms. We developed BC-Predict, to offer women when invited to the NHSBSP, which collects standard risk fa... Read More about Quantifying the effects of risk-stratified breast cancer screening when delivered in real time as routine practice versus usual screening: the BC-Predict non-randomised controlled study (NCT04359420).
Case Series of Genetically Confirmed Index Cases of Familial Hypercholesterolemia in Primary Care (2023)
Journal Article
BACKGROUND: In Malaysia, the prevalence of genetically confirmed heterozygous familial hypercholesterolemia (FH) was reported as 1 in 427. Despite this, FH remains largely underdiagnosed and undertreated in primary care. CASE REPORT: In this case... Read More about Case Series of Genetically Confirmed Index Cases of Familial Hypercholesterolemia in Primary Care.
How does cholesterol burden change the case for investing in familial hypercholesterolaemia? A cost-effectiveness analysis (2022)
Journal Article
Background and aims This study aimed to ascertain how the long-term benefits and costs of diagnosis and treatment of familial hypercholesterolaemia (FH) vary by prognostic factors and ‘cholesterol burden’, which is the effect of long-term exposure t... Read More about How does cholesterol burden change the case for investing in familial hypercholesterolaemia? A cost-effectiveness analysis.
Cardiovascular outcomes and mortality after incident ischaemic stroke in patients with a recent cancer history (2022)
Journal Article
Background: Up to 10% of patients with ischaemic stroke have comorbid cancer and stroke in these patients is thought to have a poor short-term prognosis. There is little known about the long-term cardiovascular morbidity and mortality outcomes after... Read More about Cardiovascular outcomes and mortality after incident ischaemic stroke in patients with a recent cancer history.
European Physician Survey Characterizing the Clinical Pathway and Treatment Patterns of Patients Post-Myocardial Infarction (2022)
Journal Article
Introduction: The 2019 European Society of Cardiology and European Atherosclerosis Society (2019 ESC/EAS) guidelines stress the importance of managing low-density lipoprotein cholesterol (LDL-C) after myocardial infarction (MI) to reduce the risk of... Read More about European Physician Survey Characterizing the Clinical Pathway and Treatment Patterns of Patients Post-Myocardial Infarction.
Electronic health record-based facilitation of familial hypercholesterolaemia detection sensitivity of different algorithms in genetically confirmed patients (2022)
Journal Article
Aims: Familial hypercholesterolaemia (FH) is a disorder of LDL cholesterol clearance, resulting in increased risk of cardiovascular disease. Recently, we developed a Dutch Lipid Clinic Network (DLCN) criteria-based algorithm to facilitate FH detectio... Read More about Electronic health record-based facilitation of familial hypercholesterolaemia detection sensitivity of different algorithms in genetically confirmed patients.
Identifying Patients with Bicuspid Aortic Valve Disease in UK Primary Care: A Case–Control Study and Prediction Model (2022)
Journal Article
Bicuspid aortic valve disease (BAV) is the most common congenital heart condition, and early detection can improve outcomes for patients. In this case–control study, patients with a diagnosis of BAV were identified from their electronic primary-care... Read More about Identifying Patients with Bicuspid Aortic Valve Disease in UK Primary Care: A Case–Control Study and Prediction Model.
Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study (2022)
Journal Article
Background Patients with ischemic stroke are considered a very high risk population for subsequent cardiovascular events and guidelines recommend intensive preventive strategies. However, there is no clear recommendation that patients with hemorrhagi... Read More about Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study.
Introducing genetic testing with case finding for familial hypercholesterolaemia in primary care: qualitative study of patient and health professional experience (2022)
Journal Article
Background: Familial hypercholesterolaemia (FH) is a common inherited condition causing elevated cholesterol, premature heart disease and early death. Although FH can be effectively treated, over 80% of people with FH remain undetected. Aim: To e... Read More about Introducing genetic testing with case finding for familial hypercholesterolaemia in primary care: qualitative study of patient and health professional experience.
Cost-Effectiveness of Screening Algorithms for Familial Hypercholesterolaemia in Primary Care (2022)
Journal Article
Although familial hypercholesterolemia (FH) screening within primary care is considered cost-effective, which screening approach is cost-effective has not been established. This study determines the cost-effectiveness of six case-finding strategies f... Read More about Cost-Effectiveness of Screening Algorithms for Familial Hypercholesterolaemia in Primary Care.
Ethnic disparities in mortality among overweight or obese adults with newly diagnosed type 2 diabetes: a population-based cohort study (2022)
Journal Article
Purpose: Ethnic variation in risk of type 2 diabetes is well established, but its impact on mortality is less well understood. This study investigated the risk of all-cause and cardiovascular mortality associated with newly diagnosed type 2 diabetes... Read More about Ethnic disparities in mortality among overweight or obese adults with newly diagnosed type 2 diabetes: a population-based cohort study.
Understanding the barriers and enablers of pharmacogenomic testing in primary care: a qualitative systematic review with meta-aggregation synthesis (2021)
Journal Article
Introduction: Pharmacogenomic testing can indicate which drugs may have limited therapeutic action or lead to adverse effects, hence guiding rational and safe prescribing. However, in the UK and other countries, there are still significant barriers t... Read More about Understanding the barriers and enablers of pharmacogenomic testing in primary care: a qualitative systematic review with meta-aggregation synthesis.
Determining propensity for sub-optimal low-density lipoprotein cholesterol response to statins and future risk of cardiovascular disease (2021)
Journal Article
Background: Variability in low-density lipoprotein cholesterol (LDL-C) response to statins is underappreciated. We characterised patients by their statin response (SR), baseline risk of cardiovascular disease (CVD) and 10-year CVD outcomes. Method... Read More about Determining propensity for sub-optimal low-density lipoprotein cholesterol response to statins and future risk of cardiovascular disease.
Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care (2021)
Journal Article
Objectives: Guidance recommends statin treatment in Familial Hypercholesterolaemia (FH) achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). We assessed statin prescribing rates and LDL-cholesterol treatment goal attainmen... Read More about Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care.
Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care (2021)
Journal Article
Objective Familial hypercholesterolaemia (FH) is a common inherited disorder causing premature coronary heart disease (CHD) and death. We have developed the novel Familial Hypercholesterolaemia Case Ascertainment Tool (FAMCAT 1) case-finding algorith... Read More about Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care.
Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease (2021)
Journal Article
Background: Globally, about 6% of children are born with a serious birth defect of genetic or partially genetic origin. Carrier screening or testing is one way to identify couples at increased risk of having a child with an autosomal recessive condit... Read More about Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.
Strategies for screening for familial hypercholesterolaemia in primary care and other community settings (2021)
Journal Article
Background: Familial hypercholesterolaemia is a common inherited condition that is associated with premature cardiovascular disease. The increased cardiovascular morbidity and mortality, resulting from high levels of cholesterol since birth, can be p... Read More about Strategies for screening for familial hypercholesterolaemia in primary care and other community settings.
Effectiveness of cascade testing strategies in relatives for familial hypercholesterolemia: A systematic review and meta-analysis (2021)
Journal Article
Background and aims: Cascade testing in relatives of index cases is the most cost-effective approach to identifying people with familial hypercholesterolemia (FH); however, it is currently unclear which strategy to contact relatives would be the most... Read More about Effectiveness of cascade testing strategies in relatives for familial hypercholesterolemia: A systematic review and meta-analysis.
Obesity and long-term outcomes after incident stroke: a prospective population-based cohort study (2021)
Journal Article
Background: The association between obesity, major adverse cardiovascular events (MACE), and mortality in patients with incident stroke is not well established. We assessed the relationship between body mass index (BMI) and MACE in patients with inci... Read More about Obesity and long-term outcomes after incident stroke: a prospective population-based cohort study.
Case-finding and genetic testing for familial hypercholesterolaemia in primary care (2021)
Journal Article
Objective: Familial Hypercholesterolaemia (FH) is a common inherited disorder causing premature heart disease and death. We have developed novel case-finding algorithms (FAMCAT version 1 & 2) for application in primary care, to improve detection of... Read More about Case-finding and genetic testing for familial hypercholesterolaemia in primary care.
Sex disparity in subsequent outcomes in survivors of coronary heart disease (2021)
Journal Article
Objective: Evidence on sex differences in outcomes after developing coronary heart disease (CHD) has focused on recurrent CHD, all-cause mortality or revascularisation. We assessed sex disparities in subsequent major adverse cardiovascular events (M... Read More about Sex disparity in subsequent outcomes in survivors of coronary heart disease.
Pharmacogenomic testing to support prescribing in primary care: A structured review of implementation models (2021)
Journal Article
The application of pharmacogenomics could meaningfully contribute toward medicines optimization within primary care. This review identified 13 studies describing eight implementation models utilizing a multi-gene pharmacogenomic panel within a primar... Read More about Pharmacogenomic testing to support prescribing in primary care: A structured review of implementation models.
Subjective vision and hearing impairment and falls among community-dwelling adults: a prospective study in the Survey of Health, Ageing and Retirement in Europe (SHARE) (2021)
Journal Article
Purpose: To investigate the association between vision and hearing impairment and falls in community-dwelling adults aged ≥ 50 years. Methods: This is a prospective study on 50,986 participants assessed in Waves 6 and 7 of the Survey of Health, Agein... Read More about Subjective vision and hearing impairment and falls among community-dwelling adults: a prospective study in the Survey of Health, Ageing and Retirement in Europe (SHARE).
Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study (2021)
Journal Article
Objective: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD)... Read More about Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study.
Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK (2021)
Journal Article
Background: Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantifi... Read More about Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK.
Systematic Identification of Familial Hypercholesterolaemia in Primary Care—A Systematic Review (2021)
Journal Article
Familial hypercholesterolaemia (FH) is a common inherited cause of premature cardiovascular disease, but the majority of patients remain undiagnosed. The aim of this systematic review was to assess the effectiveness of interventions to systematically... Read More about Systematic Identification of Familial Hypercholesterolaemia in Primary Care—A Systematic Review.
Sex, Age, and Socioeconomic Differences in Nonfatal Stroke Incidence and Subsequent Major Adverse Outcomes (2021)
Journal Article
Background and Purpose: Data about variations in stroke incidence and subsequent major adverse outcomes are essential to inform secondary prevention and prioritizing resources to those at the greatest risk of major adverse end points. We aimed to de... Read More about Sex, Age, and Socioeconomic Differences in Nonfatal Stroke Incidence and Subsequent Major Adverse Outcomes.
Identifying, managing and supporting patients with a rare disease (2020)
Journal Article
Rare diseases (RDs) are defined as diseases that affect less than 1 in 2000 people, 71.9% are genetic and 69.9% have symptom onset in childhood. There are an estimated 8000 rare diseases, and although individually rare, collectively they are common,... Read More about Identifying, managing and supporting patients with a rare disease.
Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study (2020)
Journal Article
Background: Familial hypercholesterolaemia (FH) is an inherited lipid disorder causing premature heart disease, which is severely underdiagnosed. Improving the identification of people with FH in primary care settings would help to reduce avoidable h... Read More about Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study.
Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care (2020)
Journal Article
Familial hypercholesterolaemia (FH) is a common inherited disorder, causing lifelong elevated low-density lipoprotein cholesterol (LDL-C). Most individuals with FH remain undiagnosed, precluding opportunities to prevent premature heart disease and de... Read More about Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care.
Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records (2020)
Journal Article
Background and aims: The UK Simon Broome (SB) familial hypercholesterolaemia (FH) register previously reported 3-fold higher standardised mortality ratio for cardiovascular disease (CVD) in women compared to men from 2009 to 2015. Here we examined se... Read More about Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records.
Specialist recommendation for chemoprevention medications in patients at familial risk of breast cancer: a cross-sectional survey in England (2020)
Journal Article
In England, the National Institute for Health and Care Excellence guideline for familial breast cancer recommends chemoprevention for women at high and moderate familial risk of breast cancer. However, prescribing of chemoprevention has not improved... Read More about Specialist recommendation for chemoprevention medications in patients at familial risk of breast cancer: a cross-sectional survey in England.
Putting the voices and insights of migrants and diverse ethnic groups at the centre of our response to COVID-19 (2020)
Journal Article
There is increasing evidence of inequities in COVID-19 infection, disease severity, and mortality across diverse ethnic groups. Despite calls to ensure ethnicity is integral to COVID-19 research, opportunities have been missed to engage with individ... Read More about Putting the voices and insights of migrants and diverse ethnic groups at the centre of our response to COVID-19.
Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK (2020)
Journal Article
The emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes Coronavirus Disease 2019 (COVID-19) has resulted in a pandemic. SARS-CoV-2 is highly contagious and its severity highly variable. The fatality rate i... Read More about Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK.
Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models (2020)
Journal Article
Introduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. With advances in early diagnosis and treatment of CVD and increasing life expectancy, more people are surviving initial CVD events. However, models t... Read More about Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models.
Is family history still underutilised? Exploring the views and experiences of primary care doctors in Malaysia (2020)
Journal Article
Family history has long been recognised as a non-invasive and inexpensive tool to identify individuals at risk of genetic conditions. Even in the era of evolving genetic and genomic technology, the role of family history in predicting individual risk... Read More about Is family history still underutilised? Exploring the views and experiences of primary care doctors in Malaysia.
Background In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE-approved more frequent screening and/ or chemo... Read More about What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420).
Improving primary care identification of familial breast cancer risk using proactive invitation and decision support (2020)
Journal Article
Family history of breast cancer is a key risk factor, accounting for up to 10% of cancers. We evaluated the proactive assessment of familial breast cancer (FBC) risk in primary care. Eligible women (30 to 60 years) were recruited from eight English g... Read More about Improving primary care identification of familial breast cancer risk using proactive invitation and decision support.
The introduction of risk stratified screening into the NHS Breast Screening Programme: Views from British-Pakistani women (2020)
Journal Article
Background: UK national guidelines suggest women at high-risk of breast cancer should be offered more frequent screening or preventative medications. Currently, only 1 in 6 high-risk women are identified. One route to identify more high-risk women is... Read More about The introduction of risk stratified screening into the NHS Breast Screening Programme: Views from British-Pakistani women.
Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study (2020)
Journal Article
Objective: Clinically-applicable diabetes severity measures are lacking, with no previous studies compared their predictive value to HbA1c. We developed and validated a type 2 diabetes severity score (DISSCO) and evaluated its association with risks... Read More about Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study.
How genomic information is accessed in clinical practice: an electronic survey of UK general practitioners (2020)
Journal Article
Genomic technologies are having an increasing impact across medicine, including primary care. To enable their wider adoption and realise their potential, education of primary healthcare practitioners will be required. To enable the development of suc... Read More about How genomic information is accessed in clinical practice: an electronic survey of UK general practitioners.
Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care (2020)
Journal Article
© 2020, The Author(s). Family history of breast and related cancers can indicate increased breast cancer (BC) risk. In national familial breast cancer (FBC) guidelines, the risk is stratified to guide referral decisions. We aimed to identify characte... Read More about Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care.
Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women (2019)
Journal Article
Objectives: Previous research has largely attempted to explore breast screening experiences of South Asian women by combining opinions from Pakistani, Bangladeshi and Indian women. This research often fails to reach the most underserved sub-groups of... Read More about Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women.
HEART UK consensus statement on Lipoprotein(a): A call to action (2019)
Journal Article
Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a... Read More about HEART UK consensus statement on Lipoprotein(a): A call to action.
Risk prediction of new AF: is there a role for artificial intelligence? (2019)
Journal Article
LDL cholesterol response to statins and future risk of cardiovascular disease (2019)
Journal Article
The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort (2019)
Journal Article
Background: The presence of additional chronic conditions has a significant impact on the treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of comorbidities in this population. The aims of this study are to quanti... Read More about The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort.
How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise (2019)
Journal Article
Objectives: (1) To explore professional and lay stakeholder views on the design and delivery of services in the area of consanguinity and genetic risk. (2) To identify principles on which there is sufficient consensus to warrant inclusion in a nation... Read More about How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise.
Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study (2019)
Journal Article
Background and aims: Familial hypercholesterolaemia (FH) is a known major cause of premature heart disease. However, the risks of atherosclerotic disease in other vascular regions are less known. We determined the risk of major cardiovascular disease... Read More about Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study.
Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review (2019)
Journal Article
This systematic review evaluated the effectiveness of strategies to identify and manage patients with familial risk of breast, ovarian, colorectal and prostate cancer in primary careto improve clinical outcomes. MEDLINE, EMBASE, CINAHL and Cochrane l... Read More about Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review.
Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care (2019)
Journal Article
Background: The vast majority of individuals with familial hypercholesterolaemia (FH) in the general population remain unidentified worldwide. Recognising patients most at risk of having the condition, to enable targeted specialist assessment and tre... Read More about Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care.
Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease (2019)
Journal Article
Objective: To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of CVD. Method: Prospective cohort study of 165,411 primary care patients, from the UK Clinical Practice Research... Read More about Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease.
Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches (2019)
Journal Article
Background: Prognostic modelling using standard methods is well-established, particularly for predicting risk of single diseases. Machine-learning may offer potential to explore outcomes of even greater complexity, such as premature death. This stud... Read More about Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches.
Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review (2019)
Journal Article
Aims: To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes. Methods: We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data?based diabetes?sp... Read More about Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review.
Barriers to a software reminder system for risk assessment of stroke in atrial fibrillation: a process evaluation of a cluster randomised trial in general practice (2018)
Journal Article
Background: Oral anticoagulants reduce the risk of stroke in patients with atrial fibrillation (AF), but are underused. AURAS-AF (AUtomated Risk Assessment for Stroke in AF) is a software tool designed to identify eligible patients and promote discus... Read More about Barriers to a software reminder system for risk assessment of stroke in atrial fibrillation: a process evaluation of a cluster randomised trial in general practice.
Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part (2018)
Journal Article
Fifty per cent of first-degree relatives of index cases with familial hypercholesterolemia (FH) inherit the disorder. Despite cascade screening being the most cost-effective method for detecting new cases, only a minority of individuals with FH are c... Read More about Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part.
Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.
Cost-utility analysis of searching electronic health records and cascade testing to identify and diagnose familial hypercholesterolaemia in England and Wales (2018)
Journal Article
Background and aims: The cost effectiveness of cascade testing for familial hypercholesterolaemia (FH) is well recognised. Less clear is the cost effectiveness of FH screening when it includes case identification strategies that incorporate routinely... Read More about Cost-utility analysis of searching electronic health records and cascade testing to identify and diagnose familial hypercholesterolaemia in England and Wales.
Improving identification & management of familial hypercholesterolaemia in primary care: pre- and post-intervention study (2018)
Journal Article
Background and Aims: Familial hypercholesterolaemia (FH) is a major cause of premature heart disease but remains unrecognised in most patients. This study investigated if a systematic primary care-based approach to identify and manage possible FH imp... Read More about Improving identification & management of familial hypercholesterolaemia in primary care: pre- and post-intervention study.
Does bone mineral density improve the predictive accuracy of fracture risk assessment?: a prospective cohort study in Northern Denmark (2018)
Journal Article
Objective: To evaluate the added predictive accuracy of bone mineral density (BMD) to fracture risk assessment.Design Prospective cohort study using data between 01 January 2010 and 31 December 2012. Setting: North Denmark Osteoporosis Clinic of r... Read More about Does bone mineral density improve the predictive accuracy of fracture risk assessment?: a prospective cohort study in Northern Denmark.
Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings (2018)
Journal Article
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The purpose of this review is to assess the effectiveness of interventions to systematically improve identification of FH in non-specialist settings compared t... Read More about Strategies for identifying familial hypercholesterolaemia in non-specialist clinical settings.
Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease (2018)
Journal Article
Background: Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rate... Read More about Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.
Inclusion of diverse populations in genomic research and health services: Genomix workshop report (2017)
Journal Article
Clinical genetic services and genomic research are rapidly developing but, historically, those with the greatest need are the least to benefit from these advances. This encompasses low-income communities, including those from ethnic minority and indi... Read More about Inclusion of diverse populations in genomic research and health services: Genomix workshop report.
Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal (2017)
Journal Article
As part of its single technology appraisal (STA) process, the UK National Institute for Health and Care Excellence (NICE) invited the manufacturer of evolocumab (Amgen) to submit evidence on the clinical and cost effectiveness of evolocumab. The appr... Read More about Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal.
Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis (2017)
Journal Article
Objective: To determine whether sickle cell carriers (‘sickle cell trait’) have an increased risk of venous thromboembolism (VTE). Design: Cohort study with nested case-control analysis. Setting: General population with data from 609 UK gener... Read More about Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis.
An automated software system to promote anticoagulation and reduce stroke risk: cluster-randomized controlled trial (2017)
Journal Article
Background and Purpose: Oral anticoagulants (OAC) substantially reduce risk of stroke in atrial fibrillation, but uptake is suboptimal. Electronic health records enable automated identification of people at risk but not receiving treatment. We inve... Read More about An automated software system to promote anticoagulation and reduce stroke risk: cluster-randomized controlled trial.
Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study (2016)
Journal Article
Objectives: To assess the feasibility of improving identification of familial hypercholesterolaemia (FH) in primary care, and of collecting outcome measures to inform a future trial. Design: Feasibility intervention study. Setting: 6 general practi... Read More about Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study.
The role of cost-effectiveness analysis in the development of indicators to support incentive-based behaviour in primary care in England (2016)
Journal Article
In England, general practitioners are incentivized through a national pay-for-performance scheme to adopt evidence-based quality improvement initiatives using a portfolio of Quality and Outcomes Framework (QOF) indicators. We describe the development... Read More about The role of cost-effectiveness analysis in the development of indicators to support incentive-based behaviour in primary care in England.
Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study (2015)
Journal Article
Aim: This study assesses the feasibility of collecting genetic samples and self-reported outcome measures after cardiovascular risk assessment, and presenting the genetic test results to participants. Background: Coronary heart disease (CHD) genetic... Read More about Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study.
Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study (2015)
Journal Article
Objectives To explore perspectives on enhancing physical activity and diet among South Asians in urban deprived communities at high risk of chronic disease and to inform development of culturally appropriate health promotion intervention. Des... Read More about Perspectives on enhancing physical activity and diet for health promotion among at-risk urban UK South Asian communities: a qualitative study.
Improving identification of familial hypercholesterolaemia in primary care: Derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT) (2014)
Journal Article
Objective: Heterozygous familial hypercholesterolaemia (FH) is a common autosomal dominant disorder. The vast majority of affected individuals remain undiagnosed, resulting in lost opportunities for preventing premature heart disease. Better use of r... Read More about Improving identification of familial hypercholesterolaemia in primary care: Derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT).
Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening (2014)
Journal Article
Universal newborn screening for sickle cell disorders and cystic fibrosis aims to enable the early identification and treatment of affected babies. Screening can also identify infants who are healthy carriers, with carrier results being the commonest... Read More about Parents' responses to receiving sickle cell or cystic fibrosis carrier results for their child following newborn screening.
Introducing genetic testing for cardiovascular disease in primary care: a qualitative study (2014)
Journal Article
Background: While primary care systematically offers conventional cardiovascular risk assessment, genetic tests for coronary heart disease (CHD) are increasingly commercially available to patients. It is unclear how individuals may respond to these n... Read More about Introducing genetic testing for cardiovascular disease in primary care: a qualitative study.
Availability and quality of coronary heart disease family history in primary care medical records: implications for cardiovascular risk assessment (2014)
Journal Article
Background: The potential to use data on family history of premature disease to assess disease risk is increasingly recognised, particularly in scoring risk for coronary heart disease (CHD). However the quality of family health information in primary... Read More about Availability and quality of coronary heart disease family history in primary care medical records: implications for cardiovascular risk assessment.