Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom

Khalid, Sara; Prieto Alhambra, Daniel; Hasheminasab, Seyed Alireza; Vinogradova, Yana; Qureshi, Nadeem; Ratzinger, Michaela; Brunetti, Vanessa; Salas, Adrian; Canals, Laura

Abstract

Using the UK Clinical Practice Research Datalink, our cohort study matched 237,297 individuals with hearing loss (HL) to 829,431 without HL. The study found an 8-10% higher risk of major osteoporotic fracture in individuals with HL compared to those without. Additionally, within the HL cohort, we identified risk factors for potential inclusion in fracture risk models. PURPOSE: Assess association between hearing loss (HL) and major osteoporotic fracture (MOF; spine, wrist/forearm, shoulder/proximal humerus, hip) in individuals aged ≥ 60years, and risk factors for MOF in individuals with HL. METHODS: From the UK Clinical Practice Research Datalink, our cohort study matched individuals aged ≥ 60years diagnosed with HL (READ/ICD-10 codes; 01January2001-31December2021; index event), without secondary osteoporosis causes, with up to five individuals without HL (birth, index year, sex, general practice). Incidence rates and Cox proportional hazard ratios (HL vs. no HL; stratified by low/high fracture risk) were calculated for MOF and hip fracture; multivariate logistic regression assessed risk factors for MOF and hip fracture (HL cohort). RESULTS: A total of 237,297 individuals with HL matched to 829,431 without HL, with a median age of 74 and 72years, respectively. Compared with those without HL, individuals with HL had greater frailty (severe electronic frailty index, 5.9% vs. 2.7%), higher incidence of prior falls (14.1% vs. 10.6%), longer mean follow-up with higher incidence of MOF and hip fractures (5.1 vs. 4.4years, 20.1 and 5.32 vs. 16.58 and 4.54 per 1000 person-years, respectively) and higher risk of MOF and hip fracture (adjusted HR, 1.10 and 1.08, respectively). Significant risk factors for MOF and hip fracture included age ≥ 70years, fracture history, falls, osteoporosis diagnosis, chronic obstructive pulmonary disorder and cardiovascular disease (HL cohort). CONCLUSION: In individuals with HL, we observed an 8-10% higher risk of MOF and hip fracture versus individuals without HL and identified risk factors for potential inclusion in fracture risk models.

Citation

Khalid, S., Prieto Alhambra, D., Hasheminasab, S. A., Vinogradova, Y., Qureshi, N., Ratzinger, M., Brunetti, V., Salas, A., & Canals, L. (2025). Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom. Archives of Osteoporosis, 20(1), Article 14. https://doi.org/10.1007/s11657-024-01484-2

• Journal Article Type: Article
• Acceptance Date: Dec 7, 2024
• Online Publication Date: Jan 28, 2025
• Publication Date: Jan 28, 2025
• Deposit Date: Feb 5, 2025
• Publicly Available Date: Feb 5, 2025
• Journal: Archives of Osteoporosis
• Print ISSN: 1862-3522
• Electronic ISSN: 1862-3514
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 1
• Article Number: 14
• DOI: https://doi.org/10.1007/s11657-024-01484-2
• Keywords: Hearing loss; Hearing impairment; Osteoporosis; Major osteoporotic fracture; Hip fracture; Risk factor
• Public URL: https://nottingham-repository.worktribe.com/output/45039006
• Publisher URL: https://link.springer.com/article/10.1007/s11657-024-01484-2