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Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain (2006)
Journal Article
Soufi, A., Smith, C., Clarke, A. R., Gaston, K., & Jayaraman, P. (2006). Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain. Journal of Molecular Biology, 358(4), 943-962. https://doi.org/10.1016/j.jmb.2006.02.020

Homeodomain proteins regulate multiple developmental pathways by altering gene expression temporally and in a tissue-specific fashion. The Proline Rich Homeodomain protein (PRH/Hex) is a transcription factor and an essential regulator of embryonic de... Read More about Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.

Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy (2006)
Journal Article
Green, K. L., Southgate, T. D., Mulryan, K., Fairbairn, L. J., Stern, P. L., & Gaston, K. (2006). Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy. Human Gene Therapy, 17(2), 147-157. https://doi.org/10.1089/hum.2006.17.147

Human papillomaviruses (HPVs) are a causative agent of cervical cancer and are implicated in several other types of malignant disease including cancer of the vulva, oral cancer, and skin cancer. In HPV-transformed cells, expression of the viral E6 an... Read More about Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy.

Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction (2006)
Journal Article
Soufi, A., Gaston, K., & Jayaraman, P. (2006). Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction. International Journal of Biological Macromolecules, 39(1-3), 45-50. https://doi.org/10.1016/j.ijbiomac.2006.01.004

The Proline-Rich Homeodomain (PRH) protein is a regulator of transcription and translation and plays a key role in the control of cell proliferation and cell differentiation. PRH contains an N-terminal proline-rich domain that can repress transcripti... Read More about Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction.

Measuring the induction or inhibition of apoptosis by HPV proteins (2005)
Book Chapter
Kowalczyk, A. M., Roeder, G. E., Green, K., Stephens, D. J., & Gaston, K. (2005). Measuring the induction or inhibition of apoptosis by HPV proteins. In C. Davy, & J. Doorbar (Eds.), Human Papillomaviruses: methods and protocols (419 -- 432). Totowa, NJ: Humana Press. https://doi.org/10.1385/1-59259-982-6%3A419

Many viral proteins influence the cellular pathways that control cell proliferation and cell death. Some viral proteins trigger apoptotic cell death, and this may be important in host defense and viral spread. In other cases, viral proteins inhibit a... Read More about Measuring the induction or inhibition of apoptosis by HPV proteins.

Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus (2003)
Journal Article
Dell, G., Wilkinson, K. W., Tranter, R., Parish, J., Brady, R. L., & Gaston, K. (2003). Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. Journal of Molecular Biology, 334(5), 979-991. https://doi.org/10.1016/j.jmb.2003.10.009

Human papillomaviruses (HPVs) that infect the genital tract can be divided into two groups: high-risk HPV types, such as HPV 16 and HPV 18, are associated with cancer, low-risk HPV types, such as HPV 6, are associated with benign warts. In both high-... Read More about Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus.

The transcriptional repressor protein PRH interacts with the proteasome (2003)
Journal Article
Bess, K. L., Swingler, T. E., Rivett, A. J., Gaston, K., & Jayaraman, P. (2003). The transcriptional repressor protein PRH interacts with the proteasome. Biochemical Journal, 374(3), 667-675. https://doi.org/10.1042/BJ20030769

PRH (proline-rich homeodomain protein)/Hex is important in the control of cell proliferation and differentiation. We have shown previously that PRH contains two domains that can bring about transcriptional repression independently; the PRH homeodomai... Read More about The transcriptional repressor protein PRH interacts with the proteasome.

Transcriptional repression in eukaryotes: repressors and repression mechanisms (2003)
Journal Article
Gaston, K., & Jayaraman, P. (2003). Transcriptional repression in eukaryotes: repressors and repression mechanisms. Cellular and Molecular Life Sciences, 60(4), 721-741. https://doi.org/10.1007/s00018-003-2260-3

For many, if not most genes, the initiation of transcription is the principle point at which their expression is regulated. Transcription factors, some of which bind to specific DNA sequences, generally either activate or repress promoter activity an... Read More about Transcriptional repression in eukaryotes: repressors and repression mechanisms.

Purification of the proline-rich homeodomain protein (2002)
Journal Article
Butcher, A. J., Gaston, K., & Jayaraman, P. (2003). Purification of the proline-rich homeodomain protein. Journal of Chromatography B, 786(1-2), 3-6. https://doi.org/10.1016/S1570-0232%2802%2900740-7

The proline-rich homeodomain protein (PRH), also known as Hex, is a transcriptional repressor expressed in a variety of cell types. The PRH protein contains a proline-rich N-terminal domain that can repress transcription when attached to a heterologo... Read More about Purification of the proline-rich homeodomain protein.

The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance (2002)
Journal Article
Rees, L., Wood, N., Gillespie, K., Lai, K., Gaston, K., & Mathieson, P. (2002). The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance. Cellular and Molecular Life Sciences, 59(3), 560-569. https://doi.org/10.1007/s00018-002-8448-0

Genotypic variation in the human interleukin-10 (IL-10) promoter may account for marked inter-individual variation in IL-10 production and may influence susceptibility to autoimmune diseases. The G/A polymorphism at position -1082 has been linked to... Read More about The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance.

Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells (2001)
Journal Article
Davidson, E. J., Brown, M. D., Burt, D. J., Parish, J. L., Gaston, K., Kitchener, H. C., …Stern, P. L. (2001). Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells. International Journal of Cancer, 94(6), 807-812. https://doi.org/10.1002/ijc.1558

Persistent infection with human papillomavirus (HPV) type 16 has been implicated in the etiology of cervical cancer. The E2 protein is required early in viral infection and therefore may serve as a useful immune target for a vaccine aimed at preventi... Read More about Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells.

Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer (2001)
Journal Article
Dell, G., & Gaston, K. (2001). Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer. Cellular and Molecular Life Sciences, 58(12), 1923-1942. https://doi.org/10.1007/pl00000827

Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix, a disease responsible for at least 200,000 deaths per year worldwide. Over 100 different types of HPV have been identified and these can... Read More about Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer.

Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins (2001)
Journal Article
Webster, K., Taylor, A., & Gaston, K. (2001). Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins. Journal of General Virology, 82(1), 201-213. https://doi.org/10.1099/0022-1317-82-1-201

Human papillomavirus (HPV) type 16 infects the genital tract and is generally acknowledged to be a causative agent of cervical cancer. HPV infection alone is not sufficient to induce cervical cancer and other factors such as steroid hormones are thou... Read More about Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins.

Investigation of human T cell responses to HPV16 E2 (2000)
Presentation / Conference Contribution
Davidson, E., Brown, M., Burt, D., Mulryan, K., Clayton, A., Gaston, K., …Stern, P. (2000). Investigation of human T cell responses to HPV16 E2. In The 18th International Papillomavirus Conference

Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors (2000)
Journal Article
Vernon, E. G., & Gaston, K. (2000). Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors. BBA - Biochimica et Biophysica Acta, 1492(1), 172-179. https://doi.org/10.1016/S0167-4781%2800%2900116-0

The human Surf-1 and Surf-2 genes are divergently transcribed and share a single bi-directional promoter. The addition of serum growth factors to serum-starved cells activates transcription in the Surf-1 direction, but has no effect on transcription... Read More about Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors.

The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway (2000)
Journal Article
Webster, K., Parish, J., Pandya, M., Stern, P. L., Clarke, A. R., & Gaston, K. (2000). The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway. Journal of Biological Chemistry, 275(1), 87-94. https://doi.org/10.1074/jbc.275.1.87

The human papillomavirus (HPV) E2 protein regulates viral gene expression and is also required for viral replication. HPV-transformed cells often contain chromosomally integrated copies of the HPV genome in which the viral E2 gene is disrupted. We ha... Read More about The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.