Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited

Underwood, Owen; Fritzwanker, Sebastian; Glenn, Jaqueline; Blum, Nina Kathleen; Batista-Gondin, Arisbel; Drube, Julia; Hoffmann, Carsten; Briddon, Stephen J.; Schulz, Stefan; Canals, Meritxell

doi:10.1038/s42003-024-06571-1

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Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited (2024)
Journal Article
Underwood, O., Fritzwanker, S., Glenn, J., Blum, N. K., Batista-Gondin, A., Drube, J., Hoffmann, C., Briddon, S. J., Schulz, S., & Canals, M. (2024). Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited. Communications Biology, 7, Article 933. https://doi.org/10.1038/s42003-024-06571-1

Desensitisation of the mu-opioid receptor (MOR) is proposed to underlie the initiation of opioid analgesic tolerance and previous work has shown that agonist-induced phosphorylation of the MOR C-tail contributes to this desensitisation. Moreover, pho... Read More about Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited.