Robert Whelan
Neuropsychosocial profiles of current and future adolescent alcohol misusers
Whelan, Robert; Watts, Richard; Orr, Catherine A.; Althoff, Robert R.; Artiges, Eric; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L. W.; B?chel, Christian; Carvalho, Fabiana M.; Conrod, Patricia J.; Flor, Herta; Fauth-B?hler, Mira; Frouin, Vincent; Gallinat, Juergen; Gan, Gabriela; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Lawrence, Claire; Mann, Karl; Martinot, Jean-Luc; Nees, Frauke; Ortiz, Nick; Paill?re-Martinot, Marie-Laure; Paus, Tomas; Pausova, Zdenka; Rietschel, Marcella; Robbins, Trevor W.; Smolka, Michael N.; Str?hle, Andreas; Schumann, Gunter; Garavan, Hugh; Albrecht, Lisa; Arroyo, Mercedes; Aydin, Semiha; Bach, Christine; Barbot, Alexis; Bricaud, Zuleima; Bromberg, Uli; Bruehl, Ruediger; Cattrell, Anna; Czech, Katharina; Dalley, Jeffrey; Desrivieres, Sylvane; Fadai, Tahmine; Fuchs, Birgit; Gollier Briand, Fanny; Head, Kay; Heinrichs, Bert; Heym, Nadja; H?bner, Thomas; Ihlenfeld, Albrecht; Ireland, James; Ivanov, Nikolay; Jia, Tianye; Jones, Jennifer; Kepa,...
Authors
Richard Watts
Catherine A. Orr
Robert R. Althoff
Eric Artiges
Tobias Banaschewski
Gareth J. Barker
Arun L. W. Bokde
Christian B�chel
Fabiana M. Carvalho
Patricia J. Conrod
Herta Flor
Mira Fauth-B�hler
Vincent Frouin
Juergen Gallinat
Gabriela Gan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Andreas Heinz
Bernd Ittermann
Claire Lawrence
Karl Mann
Jean-Luc Martinot
Frauke Nees
Nick Ortiz
Marie-Laure Paill�re-Martinot
Tomas Paus
Zdenka Pausova
Marcella Rietschel
Trevor W. Robbins
Michael N. Smolka
Andreas Str�hle
Gunter Schumann
Hugh Garavan
Lisa Albrecht
Mercedes Arroyo
Semiha Aydin
Christine Bach
Alexis Barbot
Zuleima Bricaud
Uli Bromberg
Ruediger Bruehl
Anna Cattrell
Katharina Czech
Jeffrey Dalley
Sylvane Desrivieres
Tahmine Fadai
Birgit Fuchs
Fanny Gollier Briand
Kay Head
Bert Heinrichs
Nadja Heym
Thomas H�bner
Albrecht Ihlenfeld
James Ireland
Nikolay Ivanov
Tianye Jia
Jennifer Jones
Agnes Kepa
Dirk Lanzerath
Mark Lathrop
Herv� Lemaitre
Katharina L�demann
Lourdes Martinez-Medina
Xavier Mignon
Ruben Miranda
Kathrin M�ller
Charlotte Nymberg
Jani Pentilla
Jean-Baptiste Poline
Luise Poustka
Michael Rapp
Stephan Ripke
Sarah Rodehacke
John Rogers
Alexander Romanowski
Barbara Ruggeri
Christine Schm�l
Dirk Schmidt
Sophia Schneider
Markus Schroeder
Florian Schubert
Wolfgang Sommer
Rainer Spanagel
David Stacey
Sabina Steiner
Dai Stephens
Nicole Strache
Maren Struve
Amir Tahmasebi
Lauren Topper
Helene Vulser
Bernadeta Walaszek
Helen Werts
Steve Williams
C. Peng Wong
Juliana Yacubian
Veronika Ziesch
Abstract
A comprehensive account of the causes of alcohol misuse must accommodate individual differences in biology, psychology and environment, and must disentangle cause and effect. Animal models can demonstrate the effects of neurotoxic substances; however, they provide limited insight into the psycho-social and higher cognitive factors involved in the initiation of substance use and progression to misuse. One can search for pre-existing risk factors by testing for endophenotypic biomarkers in non-using relatives; however, these relatives may have personality or neural resilience factors that protect them from developing dependence. A longitudinal study has potential to identify predictors of adolescent substance misuse, particularly if it can incorporate a wide range of potential causal factors, both proximal and distal, and their influence on numerous social, psychological and biological mechanisms. Here we apply machine learning to a wide range of data from a large sample of adolescents (n = 692) to generate models of current and future adolescent alcohol misuse that incorporate brain structure and function, individual personality and cognitive differences, environmental factors (including gestational cigarette and alcohol exposure), life experiences, and candidate genes. These models were accurate and generalized to novel data, and point to life experiences, neurobiological differences and personality as important antecedents of binge drinking. By identifying the vulnerability factors underlying individual differences in alcohol misuse, these models shed light on the aetiology of alcohol misuse and suggest targets for prevention. © 2014 Macmillan Publishers Limited. All rights reserved.
Citation
Whelan, R., Watts, R., Orr, C. A., Althoff, R. R., Artiges, E., Banaschewski, T., …Ziesch, V. (2014). Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature, 512(7513), 185-189. https://doi.org/10.1038/nature13402
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 23, 2014 |
Online Publication Date | Jul 2, 2014 |
Publication Date | Aug 14, 2014 |
Deposit Date | Aug 11, 2017 |
Journal | Nature |
Print ISSN | 0028-0836 |
Electronic ISSN | 1476-4687 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 512 |
Issue | 7513 |
Pages | 185-189 |
DOI | https://doi.org/10.1038/nature13402 |
Public URL | https://nottingham-repository.worktribe.com/output/733051 |
Publisher URL | https://doi.org/10.1038/nature13402 |
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