RUEDIGER THUL RUEDIGER.THUL@NOTTINGHAM.AC.UK
Associate Professor
Frequency of elemental events of intracellular Ca²⁺ dynamics
Thul, Ruediger; Falcke, Martin
Authors
Martin Falcke
Abstract
The dynamics of intracellular Ca²⁺ is driven by random events called Ca²⁺ puffs, in which Ca²⁺ is liberated from intracellular stores. We show that the emergence of Ca²⁺ puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca²⁺ puffs has to account for the discrete character of the Ca²⁺ release sites and does not permit a continuous description of the number of
open channels.
Citation
Thul, R., & Falcke, M. (2006). Frequency of elemental events of intracellular Ca²⁺ dynamics. Physical Review E, 73, Article 061923. https://doi.org/10.1103/PhysRevE.73.061923
Journal Article Type | Article |
---|---|
Publication Date | Jun 29, 2006 |
Deposit Date | Nov 19, 2008 |
Publicly Available Date | Nov 19, 2008 |
Journal | Physical Review E |
Print ISSN | 2470-0045 |
Electronic ISSN | 2470-0053 |
Publisher | American Physical Society |
Peer Reviewed | Peer Reviewed |
Volume | 73 |
Article Number | 061923 |
DOI | https://doi.org/10.1103/PhysRevE.73.061923 |
Public URL | https://nottingham-repository.worktribe.com/output/703699 |
Publisher URL | http://journals.aps.org/pre/abstract/10.1103/PhysRevE.73.061923 |
Contract Date | Nov 19, 2008 |
Files
Thul-Falcke-PRE-nottseprint.pdf
(341 Kb)
PDF
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