Sulak Michael
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
Michael, Sulak; Lindsey, Fong; Katelyn, Mika; Sravanthi, Chigurupati; Lisa, Yon; Nigel P, Mongan; Richard D, Emes; Vincent J, Lynch
Authors
Fong Lindsey
Mika Katelyn
Chigurupati Sravanthi
LISA YON LISA.YON@NOTTINGHAM.AC.UK
Associate Professor
NIGEL MONGAN nigel.mongan@nottingham.ac.uk
Professor of Oncology
Emes Richard D
Lynch Vincent J
Abstract
A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here, we show that the elephant genome encodes 20 copies of the tumor suppressor gene TP53 and that the increase in TP53 copy number occurred coincident with the evolution of large body sizes, the evolution of extreme sensitivity to genotoxic stress, and a hyperactive TP53 signaling pathway in the elephant (Proboscidean) lineage. Furthermore, we show that several of the TP53 retrogenes (TP53RTGs) are transcribed and likely translated. While TP53RTGs do not appear to directly function as transcription factors, they do contribute to the enhanced sensitivity of elephant cells to DNA damage and the induction of apoptosis by regulating activity of the TP53 signaling pathway. These results suggest that an increase in the copy number of TP53 may have played a direct role in the evolution of very large body sizes and the resolution of Peto's paradox in Proboscideans.
Citation
Michael, S., Lindsey, F., Katelyn, M., Sravanthi, C., Lisa, Y., Nigel P, M., …Vincent J, L. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5, Article e11994. https://doi.org/10.7554/eLife.11994.001
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 17, 2016 |
Online Publication Date | Sep 19, 2016 |
Publication Date | Sep 19, 2016 |
Deposit Date | Oct 16, 2023 |
Publicly Available Date | Nov 28, 2023 |
Journal | eLife |
Electronic ISSN | 2050-084X |
Publisher | eLife Sciences Publications |
Peer Reviewed | Peer Reviewed |
Volume | 5 |
Article Number | e11994 |
DOI | https://doi.org/10.7554/eLife.11994.001 |
Keywords | General Immunology and Microbiology; General Biochemistry, Genetics and Molecular Biology; General Medicine; General Neuroscience |
Public URL | https://nottingham-repository.worktribe.com/output/23547283 |
Publisher URL | https://elifesciences.org/articles/11994 |
PMID | 27997337 |
Additional Information | © 2016, Sulak et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
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Publisher Licence URL
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