Parts list for a microtubule depolymerising kinesin

Friel, Claire T.; Welburn, Julie P.

Abstract

The Kinesin superfamily is a large group of molecular motors that use the turnover of ATP to regulate their interaction with the microtubule cytoskeleton. The coupled relationship between nucleotide turnover and microtubule binding is harnessed in various ways by these motors allowing them to carry out a variety of cellular functions. The Kinesin-13 family is a group of specialist microtubule depolymerising motors. Members of this family use their microtubule destabilising activity to regulate processes such as chromosome segregation, maintenance of cilia and neuronal development. Here, we describe the current understanding of the structure of this family of kinesins and the role different parts of these proteins play in their microtubule depolymerisation activity and in the wider function of this family of kinesins.

Citation

Friel, C. T., & Welburn, J. P. (2018). Parts list for a microtubule depolymerising kinesin. Biochemical Society Transactions, 46(6), 1665-1672. https://doi.org/10.1042/bst20180350

• Journal Article Type: Article
• Acceptance Date: Oct 15, 2018
• Online Publication Date: Nov 22, 2018
• Publication Date: Dec 17, 2018
• Deposit Date: May 8, 2019
• Publicly Available Date: May 13, 2019
• Journal: Biochemical Society Transactions
• Print ISSN: 0300-5127
• Electronic ISSN: 1470-8752
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 46
• Issue: 6
• Pages: 1665-1672
• DOI: https://doi.org/10.1042/bst20180350
• Public URL: https://nottingham-repository.worktribe.com/output/1874145
• Publisher URL: http://www.biochemsoctrans.org/content/46/6/1665
• Contract Date: May 13, 2019