Outputs (559)

Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes: A subgroup analysis from the FLASH-UK study (2023)
Journal Article
Leelarathna, L., Sutton, C. J., Evans, M. L., Neupane, S., Rayman, G., Lumley, S., …Wilmot, E. G. (2024). Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes: A subgroup analysis from the FLASH-UK study. Diabetic Medicine, 41(3), Article e15249. https://doi.org/10.1111/dme.15249

Aims: The FLASH-UK trial showed lower HbA1c with intermittently scanned continuous glucose monitoring (isCGM), as compared with self monitoring of blood glucose (SMBG), in adults with type 1 diabetes and HbA1c ≥58 mmol/mol (≥7.5%). Here, we present r... Read More about Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes: A subgroup analysis from the FLASH-UK study.

Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression (2023)
Journal Article
Atallah, N. M., Haque, M., Quinn, C., Toss, M. S., Makhlouf, S., Ibrahim, A., …Rakha, E. (2023). Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression. European Journal of Cancer, 195, Article 113371. https://doi.org/10.1016/j.ejca.2023.113371

Background: Breast cancer (BC) expressing low levels of human epidermal growth factor receptor 2 (HER2 Low) is an emerging category that needs further refining. This study aims to provide a comprehensive clinico-pathological and molecular profile of... Read More about Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression.

Clinical Impact of CDK4/6 Inhibitors in De Novo or PR− or Very Elderly Post-Menopausal ER+/HER2− Advanced Breast Cancers (2023)
Journal Article
Tang, H., Yeo, D., De Souza, K., Ahmad, O., Shafiq, T., Ofor, O., …Madhusudan, S. (2023). Clinical Impact of CDK4/6 Inhibitors in De Novo or PR− or Very Elderly Post-Menopausal ER+/HER2− Advanced Breast Cancers. Cancers, 15(21), Article 5164. https://doi.org/10.3390/cancers15215164

The CDK4/6 inhibitors significantly increase progression-free survival (PFS) in ER+/HER2− advanced breast cancer patients. In clinical trials, overall survival (OS) improvement has been demonstrated for ribociclib and abemaciclib but not for palbocic... Read More about Clinical Impact of CDK4/6 Inhibitors in De Novo or PR− or Very Elderly Post-Menopausal ER+/HER2− Advanced Breast Cancers.

Sociodemographic Variations in the Uptake of Faecal Immunochemical Tests in Primary Care (2023)
Journal Article
Bailey, J. A., Morton, A. J., Jones, J., Chapman, C. J., Oliver, S., Morling, J. R., …Humes, D. J. (2023). Sociodemographic Variations in the Uptake of Faecal Immunochemical Tests in Primary Care. British Journal of General Practice, 73(736), e843-e849. https://doi.org/10.3399/bjgp.2023.0033

Background: Faecal Immunochemical Testing (FIT) usage for symptomatic patients is increasing, but variations in use by sociodemographics are unknown. We introduced FIT for symptomatic patients in November 2017. Aim: Identify whether demographics, eth... Read More about Sociodemographic Variations in the Uptake of Faecal Immunochemical Tests in Primary Care.

Diagnosis and Management of Mantle Cell Lymphoma: A British Society for Haematology Guideline (2023)
Journal Article
Eyre, T. A., Bishton, M. J., McCulloch, R., O'Reilly, M., Menon, G., Iyengar, S., Lewis, D., Lambert, J., Linton, K. M., McKay, P., & Haemato-Oncology Task Force of the British Society for Haematology, H.-O. T. F. O. T. B. S. F. H. (2024). Diagnosis and Management of Mantle Cell Lymphoma: A British Society for Haematology Guideline. British Journal of Haematology, 204(1), 108-126. https://doi.org/10.1111/bjh.19131

Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function (2023)
Journal Article
Piasecki, J., Guo, Y., Jones, E. J., Phillips, B. E., Stashuk, D. W., Atherton, P. J., & Piasecki, M. (2023). Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function. Sports Medicine - Open, 9, Article 97. https://doi.org/10.1186/s40798-023-00639-8

Background: Estrogen and progesterone are the primary female sex hormones and have net excitatory and inhibitory effects, respectively, on neuronal function. Fluctuating concentrations across the menstrual cycle has led to several lines of research i... Read More about Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function.

The influence of immunodeficiency, disease features, and patient characteristics on survival in plasmablastic lymphoma (2023)
Journal Article
Di Ciaccio, P. R., Polizzotto, M. N., Cwynarski, K., Gerrie, A. S., Burton, C., Bower, M., …Hamad, N. (2024). The influence of immunodeficiency, disease features, and patient characteristics on survival in plasmablastic lymphoma. Blood, 143(2), 152-165. https://doi.org/10.1182/blood.2023021348

Plasmablastic lymphoma (PBL) is a rare and aggressive non-Hodgkin lymphoma associated with immunodeficiency, characterized by uncertain treatment approaches and an unfavourable prognosis. We conducted a multicenter, international, retrospective cohor... Read More about The influence of immunodeficiency, disease features, and patient characteristics on survival in plasmablastic lymphoma.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Preprint / Working Paper
Huang, J., Shek, N., Choy, A., Lang, C., Miller, B., Tal-Singer, R., …Brown, M. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Next-generation sequencing of pancreatic cyst wall specimens obtained using micro-forceps for improving diagnostic accuracy (2023)
Journal Article
Astbury, S., Baskar, A., Grove, J. I., Kaye, P., Aravinthan, A. D., James, M., …Venkatachalapathy, S. V. (2023). Next-generation sequencing of pancreatic cyst wall specimens obtained using micro-forceps for improving diagnostic accuracy. Endoscopy International Open, 11(10), E983-E991. https://doi.org/10.1055/a-2163-8805

Background and study aims: Pancreatic cysts are common incidental findings, with an estimated prevalence of 13-15% in imaging done for other reasons. Diagnosis often relies on collection of cyst fluid, but tissue sampling using micro-forceps may allo... Read More about Next-generation sequencing of pancreatic cyst wall specimens obtained using micro-forceps for improving diagnostic accuracy.

Sleep apnoea, gut dysbiosis and cognitive dysfunction (2023)
Journal Article
Deyang, T., Baig, A. I., Dolkar, P., Hediyal, T. A., Rathipriya, A. G., Bhaskaran, M., …Chidambaram, S. B. (2024). Sleep apnoea, gut dysbiosis and cognitive dysfunction. FEBS Journal, 291(12), 2519-2544. https://doi.org/10.1111/febs.16960

Sleep disorders are becoming increasingly common, and their distinct effects on physical and mental health require elaborate investigation. Gut dysbiosis (GD) has been reported in sleep-related disorders, but sleep apnoea is of particular significanc... Read More about Sleep apnoea, gut dysbiosis and cognitive dysfunction.