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Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin (2005)
Journal Article
Jethwa, P. H., Small, C. J., Smith, K. L., Seth, A., Darch, S. J., Abbott, C. R., Murphy, K. G., Todd, J. F., Ghatei, M. A., & Bloom, S. R. (2005). Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin. AJP - Endocrinology and Metabolism, 289(2), E301-E305. https://doi.org/10.1152/ajpendo.00404.2004

Intracerebroventricular (ICV) administration of Neuromedin U (NMU), a hypothalamic neuropeptide, or leptin, an adipostat hormone released from adipose tissue, reduces food intake and increases energy expenditure. Leptin stimulates the release of NMU... Read More about Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin.

Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis (2005)
Journal Article
Rose, P., Moore, P. K., Ming, S. H., Nam, O. C., Armstrong, J. S., & Whiteman, M. (2005). Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis. World Journal of Gastroenterology, 11(26), 3990-3997. https://doi.org/10.3748/wjg.v11.i26.3990

AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Consi... Read More about Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis.

Constitutive regulation of the Insl3 gene in rat Leydig cells (2005)
Journal Article
Sadeghian, H., Anand-Ivell, R., Balvers, M., Relan, V., & Ivell, R. (2005). Constitutive regulation of the Insl3 gene in rat Leydig cells. Molecular and Cellular Endocrinology, 241(1-2), 10-20. https://doi.org/10.1016/j.mce.2005.03.017

Insulin-like factor 3 (Insl3) is a major new product of the Leydig cells in all mammalian species so far examined. The rat Insl3 gene is encoded by two exons in close juxtaposition to the Jak3 gene. Using RT-PCR analysis we now show that in the rat t... Read More about Constitutive regulation of the Insl3 gene in rat Leydig cells.

Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells (2005)
Journal Article
Rose, P., Huang, Q., Ong, C. N., & Whiteman, M. (2005). Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology, 209(2), 105-113. https://doi.org/10.1016/j.taap.2005.04.010

A high dietary intake of cruciferous vegetables has been associated with a reduction in numerous human pathologies particularly cancer. In the current study, we examined the inhibitory effects of broccoli (Brassica oleracea var. italica) and watercre... Read More about Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells.

Insulin-like factor 3: Where are we now? (2005)
Presentation / Conference Contribution
Ivell, R., Hartung, S., & Anand-Ivell, R. (2004, September). Insulin-like factor 3: Where are we now?. Presented at Relaxin 2004, Fourth International Conference on Relaxin and Related Peptides, Wyoming, USA

Insulin-like factor 3 (INSL3), previously known as the relaxin-like factor (RLF), is a major peptide hormone secreted from the testicular Leydig cells of adult men and circulating in the blood at a concentration of approximately 1 ng/mL. Women also p... Read More about Insulin-like factor 3: Where are we now?.

Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition (2005)
Journal Article
Whiteman, M., Rose, P., Jia, L. S., Nam, S. C., Gek, S. T., Halliwell, B., & Armstrong, J. S. (2005). Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition. Free Radical Biology and Medicine, 38(12), 1571-1584. https://doi.org/10.1016/j.freeradbiomed.2005.02.030

Liver cirrhosis is often preceded by overt signs of hepatitis, including parenchymal cell inflammation and infiltration of polymorphonuclear (PMN) leukocytes. Activated PMNs release both reactive oxygen species and reactive halogen species, including... Read More about Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition.

β-Phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway (2004)
Journal Article
Rose, P., Armstrong, J. S., Chua, Y. L., Ong, C. N., & Whiteman, M. (2005). β-Phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway. International Journal of Biochemistry and Cell Biology, 37(1), 100-119. https://doi.org/10.1016/j.biocel.2004.05.018

The initiating events that lead to the induction of apoptosis mediated by the chemopreventative agent β-phenyethyl isothiocyanate (PEITC) have yet to be elucidated. In the present investigation, we examined the effects of PEITC on mitochondrial funct... Read More about β-Phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway.

Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters (2004)
Journal Article
Parr, T., Jewell, K. K., Sensky, P. L., Brameld, J. M., Bardsley, R. G., & Buttery, P. J. (2004). Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters. Archives of Biochemistry and Biophysics, 427(1), 8-15. https://doi.org/10.1016/j.abb.2004.04.001

Calpastatin is the specific endogenous inhibitor of calpain proteinase that is encoded by a single gene. Transient transfection assays in both a non-fusing skeletal muscle and non-muscle cell-line demonstrated that the putative porcine calpastatin pr... Read More about Expression of calpastatin isoforms in muscle and functionality of multiple calpastatin promoters.

Vitamin A regulation of stearoyl-CoA desaturase mRNA levels and fatty acid composition in sheep tissues (2004)
Journal Article
Daniel, Z. C., Salter, A. M., & Buttery, P. J. (2004). Vitamin A regulation of stearoyl-CoA desaturase mRNA levels and fatty acid composition in sheep tissues. Animal Science, 78(2), 237-243. https://doi.org/10.1017/s1357729800054023

The effect of vitamin A (retinol) on ovine stearoyl-CoA desaturase (SCD) mRNA levels and fatty acid composition was investigated. Sheep adipose tissue explants were maintained in culture for 24 h in the presence of all-trans retinoic acid (RA). Tissu... Read More about Vitamin A regulation of stearoyl-CoA desaturase mRNA levels and fatty acid composition in sheep tissues.