Outputs (190)

Interspecies control of development during mammalian gastrulation (2023)
Journal Article
Simpson, L., & Alberio, R. (2023). Interspecies control of development during mammalian gastrulation. Emerging Topics in Life Sciences, 7(4), 397-408. https://doi.org/10.1042/etls20230083

Gastrulation represents a pivotal phase of development and aberrations during this period can have major consequences, from minor anatomical deviations to severe congenital defects. Animal models are used to study gastrulation, however, there is cons... Read More about Interspecies control of development during mammalian gastrulation.

Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear (2023)
Journal Article
Stubbendorff, C., Hale, E., Bast, T., Cassaday, H. J., Martin, S. J., Suwansawang, S., …Stevenson, C. W. (2023). Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear. Scientific Reports, 13, Article 17631. https://doi.org/10.1038/s41598-023-44772-6

Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear. Dopamine D1-l... Read More about Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear.

In vitro determination of the protein quality of maize varieties cultivated in Malawi using the INFOGEST digestion method (2023)
Journal Article
Muleya, M., Li, D., Chiutsi-Phiri, G., Botoman, L., Brameld, J. M., & Salter, A. M. (2023). In vitro determination of the protein quality of maize varieties cultivated in Malawi using the INFOGEST digestion method. Heliyon, 9(9), Article e19797. https://doi.org/10.1016/j.heliyon.2023.e19797

There is an urgent need to alleviate protein deficiencies in low-income countries where cereal-based diets dominate. The objective of this study was to use the INFOGEST static digestion method and a recently established analytical workflow to determi... Read More about In vitro determination of the protein quality of maize varieties cultivated in Malawi using the INFOGEST digestion method.

Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep (2023)
Journal Article
Evans, N. P., Bellingham, M., Elcombe, C. S., Ghasemzadeh-Hasankolaei, M., Lea, R. G., Sinclair, K. D., & Padmanabhan, V. (2023). Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep. Environmental Toxicology and Pharmacology, 102, Article 104257. https://doi.org/10.1016/j.etap.2023.104257

Humans are ubiquitously exposed to complex mixtures of environmental chemicals (ECs). This study characterised changes in post-natal and peripubertal growth, and the activation of the reproductive axis, in male and female offspring of sheep exposed t... Read More about Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep.

Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries (2023)
Journal Article
Cassaday, H. J., Cavenagh, L., Aluthgamage, H., Crooks, A., Bonardi, C., Stevenson, C. W., …Muir, C. (2023). Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries. PLoS ONE, 18(8), Article e0290232. https://doi.org/10.1371/journal.pone.0290232

Three groups of participants (largely recruited from the UK) completed a survey to examine attitudes to the use of animals in biomedical research, after reading the lay (N = 182) or technical (N = 201) summary of a research project, or no summary (N... Read More about Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries.

Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner (2023)
Journal Article
Stubbendorff, C., Hale, E., Day, H. L. L., Smith, J., Alvaro, G. S., Large, C. H., & Stevenson, C. W. (2023). Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 127, Article 110829. https://doi.org/10.1016/j.pnpbp.2023.110829

Various psychiatric diseases are characterized by aberrant cognition and emotional regulation. This includes inappropriately attributing affective salience to innocuous cues, which can be investigated using translationally relevant preclinical models... Read More about Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner.

NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl (2023)
Journal Article
Simpson, L. A., Crowley, D., Forey, T., Acosta, H., Ferjentsik, Z., Chatfield, J., …Johnson, A. D. (2023). NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl. PLoS Biology, 21(6), Article e3002121. https://doi.org/10.1371/journal.pbio.3002121

Pluripotency defines the unlimited potential of individual cells of vertebrate embryos, from which all adult somatic cells and germ cells are derived. Understanding how the programming of pluripotency evolved has been obscured in part by a lack of da... Read More about NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl.

Review: A barnyard in the lab: prospect of generating animal germ cells for breeding and conservation (2023)
Journal Article
Strange, A., & Alberio, R. (2023). Review: A barnyard in the lab: prospect of generating animal germ cells for breeding and conservation. Animal, 17, Article 100753. https://doi.org/10.1016/j.animal.2023.100753

In vitro gametogenesis (IVG) offers broad opportunities for gaining detailed new mechanistic knowledge of germ cell biology that will enable progress in the understanding of human infertility, as well as for applications in the conservation of endang... Read More about Review: A barnyard in the lab: prospect of generating animal germ cells for breeding and conservation.

Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood (2023)
Journal Article
Elcombe, C. S., Monteiro, A., Ghasemzadeh-Hasankolaei, M., Padmanabhan, V., Lea, R., Sinclair, K. D., …Bellingham, M. (2023). Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood. Environmental Toxicology and Pharmacology, 100, Article 104152. https://doi.org/10.1016/j.etap.2023.104152

Environmental chemical (EC) exposure may be impacting male reproductive health. The translationally relevant biosolids treated pasture (BTP) sheep model was used to investigate gestational low-level EC mixture exposure on the testes of F1 male offspr... Read More about Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood.

OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems (2023)
Journal Article
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., …Wright, A. J. (2023). OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems. Communications Biology, 6, Article 463. https://doi.org/10.1038/s42003-023-04780-8

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.