Outputs (119)

Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells (2019)
Journal Article
Orfali, N., Shan‐Krauer, D., O'Donovan, T. R., Mongan, N. P., Gudas, L. J., Cahill, M. R., …McKenna, S. L. (2020). Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells. Molecular Oncology, 14(6), 1297-1309. https://doi.org/10.1002/1878-0261.12614

Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous gene exp... Read More about Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells.

Science‐in‐brief: Latex in riding arenas and racetracks identified as a risk factor for equine respiratory health (2019)
Journal Article
Hannant, D. (2020). Science‐in‐brief: Latex in riding arenas and racetracks identified as a risk factor for equine respiratory health. Equine Veterinary Journal, 52(1), 11-12. https://doi.org/10.1111/evj.13201

All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL) (2019)
Journal Article
Orfali, N., O'Donovan, T. R., Cahill, M. R., Benjamin, D., Nanus, D. M., McKenna, S. L., …Mongan, N. P. (2020). All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL). European Journal of Haematology, 104(3), 236-250. https://doi.org/10.1111/ejh.13367

Objective
In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by an abnormal PML-RARα fusion oncoprotein, leading to a block in cell differentiation. Therapeutic concentrations of all-trans-retinoic acid (ATRA) can restore... Read More about All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL).

Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii (2019)
Journal Article
Cao, X., Wang, J., Elsheikha, H. M., Li, T., Sun, L., Liang, Q., …Lin, R. (2019). Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii. Frontiers in Cellular and Infection Microbiology, 9, Article 418. https://doi.org/10.3389/fcimb.2019.00418

In this study, we characterized the role of amylo-alpha-1,6-glucosidase (Aa16GL) in the biology and infectivity of Toxoplasma gondii, using Aa16GL-deficient parasites of type I RH and type II Prugniaud (Pru) strains. The subcellular localization of A... Read More about Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii.

Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China (2019)
Journal Article
Cong, W., Zhang, N.-Z., Hu, R.-S., Zou, F.-C., Zou, Y., Zhong, W.-Y., …Elsheikha, H. M. (2020). Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China. Ecotoxicology and Environmental Safety, 189, Article 109999. https://doi.org/10.1016/j.ecoenv.2019.109999

Copyright © 2019 Elsevier Inc. All rights reserved. In the present study, we performed a cross-sectional survey to determine the occurrence and genotype distribution of T. gondii DNA in soil samples collected from different sources from six geographi... Read More about Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China.

A novel approach to welfare interventions in problem multi-cat households (2019)
Journal Article
Hill, K., Yates, D., Dean, R., & Stavisky, J. (2019). A novel approach to welfare interventions in problem multi-cat households. BMC Veterinary Research, 15, Article 434. https://doi.org/10.1186/s12917-019-2183-3

Background
Thousands of injured, stray and relinquished cats are received at the RSPCA Greater Manchester Animal Hospital each year. A significant and challenging proportion of these cats are confiscated from multicat households by RSPCA Inspectors,... Read More about A novel approach to welfare interventions in problem multi-cat households.

The development and use of Actiphage® to detect viable mycobacteria from bovine tuberculosis and Johne’s disease-infected animals (2019)
Journal Article
Swift, B. M., Meade, N., Barron, E. S., Bennett, M., Perehenic, T., Hughes, V., …Rees, C. E. (2020). The development and use of Actiphage® to detect viable mycobacteria from bovine tuberculosis and Johne’s disease-infected animals. Microbial Biotechnology, 13(3), 738-746. https://doi.org/10.1111/1751-7915.13518

© 2019 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. Here, we describe the development of a method that exploits bacteriophage D29 as a lysis agent for efficient DNA extraction from lo... Read More about The development and use of Actiphage® to detect viable mycobacteria from bovine tuberculosis and Johne’s disease-infected animals.

Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models (2019)
Journal Article
Mukhamedshina, Y., Shulman, I., Ogurcov, S., Kostennikov, A., Zakirova, E., Akhmetzyanova, E., …Rizvanov, A. (2019). Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models. Biomolecules, 9(12), Article 811. https://doi.org/10.3390/biom9120811

Here, we provide a first comparative study of the therapeutic potential of allogeneic mesenchymal stem cells derived from bone marrow (BM-MSCs), adipose tissue (AD-MSCs), and dental pulp (DP-MSCs) embedded in fibrin matrix, in small (rat) and large (... Read More about Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models.

Best practice versus farm practice: Perspectives of lecturers and students at agricultural colleges in England on management of lameness in sheep (2019)
Journal Article
Clifton, R., Reeves, M. C., Kaler, J., & Green, L. E. (2019). Best practice versus farm practice: Perspectives of lecturers and students at agricultural colleges in England on management of lameness in sheep. Journal of Rural Studies, https://doi.org/10.1016/j.jrurstud.2019.11.014

We use the concepts of trust and knowledge to explore translation of scientific evidence about treatment of ovine footrot to students studying at agricultural colleges. We explore the role of different forms of trust (companion, competence and commit... Read More about Best practice versus farm practice: Perspectives of lecturers and students at agricultural colleges in England on management of lameness in sheep.

A scoping review of the current literature exploring the nature of the horse-human relationship (2019)
Journal Article
Clough, H. .., Burford, J., England, G., & Freeman, S. L. (2019). A scoping review of the current literature exploring the nature of the horse-human relationship. Veterinary Evidence, 4(4), https://doi.org/10.18849/ve.v4i4.240

Objective: To perform a scoping review of the current evidence on the horse-human relationship.

Background: The horse-human relationship has a significant impact on how horse owners care for and make decisions for their horse.

Evidentiary value... Read More about A scoping review of the current literature exploring the nature of the horse-human relationship.