Outputs (2)

GIFT: New method for the genetic analysis of small gene effects involving small sample sizes (2022)
Journal Article
Rauch, C., Kyratzi, P., Blott, S., Bray, S., & Wattis, J. A. D. (2023). GIFT: New method for the genetic analysis of small gene effects involving small sample sizes. Physical Biology, 20(1), Article 016001. https://doi.org/10.1088/1478-3975/ac99b3

Small gene effects involved in complex/omnigenic traits remain costly to analyse using current genome-wide association methods (GWAS) because of the number of individuals required to return meaningful association(s), a.k.a. study power. Inspired by f... Read More about GIFT: New method for the genetic analysis of small gene effects involving small sample sizes.

Analysis of phenotype-genotype associations using genomic informational field theory (GIFT) (2022)
Journal Article
Wattis, J. A., Bray, S. M., Kyratzi, P., & Rauch, C. (2022). Analysis of phenotype-genotype associations using genomic informational field theory (GIFT). Journal of Theoretical Biology, 548, Article 111198. https://doi.org/10.1016/j.jtbi.2022.111198

We show how field- and information theory can be used to quantify the relationship between genotype and phenotype in cases where phenotype is a continuous variable. Given a sample population of phenotype measurements, from various known genotypes, we... Read More about Analysis of phenotype-genotype associations using genomic informational field theory (GIFT).