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Outputs (19)

Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial (2015)
Journal Article

Importance: Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease.

Objective: To evaluate the effect of autologous HSCT on refractory Crohn disease.

Design, Setting, and Pa... Read More about Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.

Ustekinumab for the treatment of Crohn's disease: can it find its niche? (2015)
Journal Article
Ebby G., S., Subrata, G., Marietta, I., & Moran, G. (2016). Ustekinumab for the treatment of Crohn's disease: can it find its niche?. Therapeutic Advances in Gastroenterology, 9(1), 26-36. https://doi.org/10.1177/1756283X15618130

Crohn’s disease is an immune-mediated disease that results in panenteric chronic inflammation in genetically predisposed individuals exposed to an appropriate environment. The past two decades have witnessed the emergence of an important class of dru... Read More about Ustekinumab for the treatment of Crohn's disease: can it find its niche?.

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study (2015)
Journal Article
Armstrong, M. J., Gaunt, P., Aithal, G. P., Barton, D., Hull, D., Parker, R., …Newsome, P. N. (in press). Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet, 387(10019), https://doi.org/10.1016/S0140-6736%2815%2900803-X

Background

Glucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models of fatty liver disease. These analogues are licensed for type 2 diabetes, but their efficacy in... Read More about Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.

Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution (2015)
Journal Article
Khalaf, A., Hoad, C., Spiller, R. C., Gowland, P. A., Moran, G. W., & Marciani, L. (2015). Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution. World Journal of Gastrointestinal Pathophysiology, 6(4), https://doi.org/10.4291/wjgp.v6.i4.140

Magnetic resonance imaging (MRI) is a well established technique that has revolutionized diagnostic radiology. Until recently, the impact that MRI has had in the assessment of gastrointestinal motor function and bowel fluid distribution in health and... Read More about Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution.

Variation in the risk of venous thromboembolism following colectomy (2015)
Journal Article
Humes, D., Walker, A., Blackwell, J., Hunt, B., & West, J. (2015). Variation in the risk of venous thromboembolism following colectomy. British Journal of Surgery, 102(13), https://doi.org/10.1002/bjs.9923

Background: Guidelines recommend extended thromboprophylaxis following colectomy for malignant disease, but not for non-malignant disease. The aim of this study was to determine absolute and relative rates of venous thromboembolism (VTE) following co... Read More about Variation in the risk of venous thromboembolism following colectomy.

Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome (2015)
Journal Article
Shaw, A. D., Schermer, C. R., Lobo, D. N., Munson, S. H., Khangulov, V., Hayashida, D. K., & Kellum, J. A. (2015). Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome. Critical Care, 19, Article 334. https://doi.org/10.1186/s13054-015-1045-z

Introduction: Intravenous (IV) fluids may be associated with complications not often attributed to fluid type. Fluids with high chloride concentrations such as 0.9 % saline have been associated with adverse outcomes in surgery and critical care. Unde... Read More about Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome.

Expression of the Helicobacter pylori virulence factor vacuolating cytotoxin A (vacA) is influenced by a potential stem-loop structure in the 5' untranslated region of the transcript (2015)
Journal Article

The vacuolating cytotoxin, VacA, is an important virulence factor secreted by the gastric pathogen Helicobacter pylori. Certain vacA genotypes are strongly associated with disease risk, but the association is not absolute. The factors determining vac... Read More about Expression of the Helicobacter pylori virulence factor vacuolating cytotoxin A (vacA) is influenced by a potential stem-loop structure in the 5' untranslated region of the transcript.

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations (2015)
Journal Article

Ulcerative colitis and Crohn’s disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,... Read More about Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.