Ustekinumab for the treatment of Crohn's disease: can it find its niche?

Ebby G., Simon; Subrata, Ghosh; Marietta, Iacucci; Moran, Gordon

Abstract

Crohn’s disease is an immune-mediated disease that results in panenteric chronic inflammation in genetically predisposed individuals exposed to an appropriate environment. The past two decades have witnessed the emergence of an important class of drugs known as anti-tumour necrosis factor (TNF) agents in the treatment of Crohn’s disease. Unfortunately, the utility of these agents have been hampered by primary and secondary nonresponse in a significant proportion of patients. Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin (IL) 12 and 23, is a novel pharmacotherapy for this patient cohort that offers an out-of-class option. It is approved for use in psoriasis and psoriatic arthritis, and has now been evaluated in phase II trials for moderate-to-severe Crohn’s disease. We here review the published literature and describe a potential clinical role for its use in this disease cohort.

Citation

Ebby G., S., Subrata, G., Marietta, I., & Moran, G. (2016). Ustekinumab for the treatment of Crohn's disease: can it find its niche?. Therapeutic Advances in Gastroenterology, 9(1), 26-36. https://doi.org/10.1177/1756283X15618130

• Journal Article Type: Article
• Acceptance Date: Oct 1, 2015
• Online Publication Date: Nov 26, 2015
• Publication Date: Jan 1, 2016
• Deposit Date: Dec 13, 2018
• Journal: Therapeutic Advances in Gastroenterology
• Print ISSN: 1756-283X
• Electronic ISSN: 1756-2848
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 1
• Pages: 26-36
• DOI: https://doi.org/10.1177/1756283X15618130
• Public URL: https://nottingham-repository.worktribe.com/output/1413163
• Publisher URL: https://journals.sagepub.com/doi/10.1177/1756283X15618130
• Additional Information: Date of acceptance is estimated.