Outputs (40)

Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle (2015)
Journal Article
Salmon, A. H. J., Lobo, D. P., Wemyss, A. M., Smith, D. J., Straube, A., Betteridge, K. B., …Arkill, K. P. (2015). Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle. Nano Research, 8(10), 3307-3315. https://doi.org/10.1007/s12274-015-0831-x

The wall shear stress (WSS) that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology (e.g. angiogenesis) and affects the microvasculature's primary... Read More about Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle.

Vascular endothelial growth factor-A165b is protective and restores endothelial glycocalyx in diabetic nephropathy (2015)
Journal Article

Diabetic nephropathy is the leading cause of ESRD in high-income countries and a growing problem across the world. Vascular endothelial growth factor-A (VEGF-A) is thought to be a critical mediator of vascular dysfunction in diabetic nephropathy, yet... Read More about Vascular endothelial growth factor-A165b is protective and restores endothelial glycocalyx in diabetic nephropathy.

IL-4 Regulates Specific Arg-1+ Macrophage sFlt-1–Mediated Inhibition of Angiogenesis (2015)
Journal Article
Wu, W.-K., Georgiadis, A., Copland, D. A., Liyanage, S., Luhmann, U. F., Robbie, S. J., …Dick, A. D. (2015). IL-4 Regulates Specific Arg-1+ Macrophage sFlt-1–Mediated Inhibition of Angiogenesis. American Journal of Pathology, 185(8), 2324-2335. https://doi.org/10.1016/j.ajpath.2015.04.013

One of the main drivers for neovascularization in age-related macular degeneration is activation of innate immunity in the presence of macrophages. Here, we demonstrate that T helper cell type 2 cytokines and, in particular, IL-4 condition human and... Read More about IL-4 Regulates Specific Arg-1+ Macrophage sFlt-1–Mediated Inhibition of Angiogenesis.

Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer (2014)
Journal Article

Angiogenesis is required for tumour growth and is induced principally by vascular endothelial growth factor A (VEGF-A). VEGF-A pre-mRNA is alternatively spliced at the terminal exon to produce two families of isoforms, pro- and anti-angiogenic, only... Read More about Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer.

Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia (2014)
Journal Article

Vascular endothelial growth factor-A (VEGF-A) is best known as a key regulator of the formation of new blood vessels. Neutralization of VEGF-A with anti-VEGF therapy e.g. bevacizumab, can be painful, and this is hypothesized to result from a loss of... Read More about Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia.

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance (2014)
Journal Article
Hamdollah Zadeh, M. A., Amin, E. M., Hoareau-Aveilla, C., Domingo, E., Symonds, K. E., Ye, X., …Bates, D. O. (2015). Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance. Molecular Oncology, 9(1), 167-178. https://doi.org/10.1016/j.molonc.2014.07.017

Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity (2014)
Journal Article

Background—Experimental studies suggest that visceral adiposity and adipose tissue dysfunction play a central role in obesity-related cardiometabolic complications. Impaired angiogenesis in fat has been implicated in the development of adipose tissue... Read More about Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity.

Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma (2014)
Journal Article
Gammons, M., Lucas, R., Dean, R., Coupland, S., Oltean, S., & Bates, D. (2014). Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma. British Journal of Cancer, 111(3), 477-485. https://doi.org/10.1038/bjc.2014.342

Resolution of the three dimensional structure of components of the glomerular filtration barrier (2014)
Journal Article
Qvortrup, K., ARKILL, K., Starborg, T., Mantell, J., Knupp, C., Michel, C., …Neal, C. (2014). Resolution of the three dimensional structure of components of the glomerular filtration barrier. BMC Nephrology, 15(1), Article 24. https://doi.org/10.1186/1471-2369-15-24

Background: The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processe... Read More about Resolution of the three dimensional structure of components of the glomerular filtration barrier.

VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A inVivo and inVitro (2013)
Journal Article
Beazley-Long, N., Hua, J., Jehle, T., Hulse, R. P., Dersch, R., Lehrling, C., …Donaldson, L. F. (2013). VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A inVivo and inVitro. American Journal of Pathology, 183(3), 918-929. https://doi.org/10.1016/j.ajpath.2013.05.031

Vascular endothelial growth factor (VEGF) A is generated as two isoform families by alternative RNA splicing, represented by VEGF-A165a and VEGF-A165b. These isoforms have opposing actions on vascular permeability, angiogenesis, and vasodilatation. T... Read More about VEGF-A165b Is an Endogenous Neuroprotective Splice Isoform of Vascular Endothelial Growth Factor A inVivo and inVitro.