Resolution of the three dimensional structure of components of the glomerular filtration barrier

Qvortrup, Klaus; ARKILL, KENTON; Starborg, Tobias; Mantell, Judith; Knupp, Carlo; Michel, Charles; Harper, Steve; Salmon, Andy; Squire, John; Bates, Dave; Neal, Chris

Abstract

Background: The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (

Citation

Qvortrup, K., ARKILL, K., Starborg, T., Mantell, J., Knupp, C., Michel, C., Harper, S., Salmon, A., Squire, J., Bates, D., & Neal, C. (2014). Resolution of the three dimensional structure of components of the glomerular filtration barrier. BMC Nephrology, 15(1), Article 24. https://doi.org/10.1186/1471-2369-15-24

• Journal Article Type: Article
• Acceptance Date: Jan 21, 2014
• Online Publication Date: Feb 1, 2014
• Publication Date: Feb 1, 2014
• Deposit Date: Aug 28, 2018
• Journal: BMC Nephrology
• Electronic ISSN: 1471-2369
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Issue: 1
• Article Number: 24
• DOI: https://doi.org/10.1186/1471-2369-15-24
• Public URL: https://nottingham-repository.worktribe.com/output/1104954
• Publisher URL: https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-15-24
• PMID: 00033212