John squire and endothelial glycocalyx structure: an unfinished story

Arkill, Kenton P.; Michel, C. Charles; Rider, Elizabeth V. M.; Wood, Elise A.; Small, Mathew O.; Brown, Jennifer L. E.; Kinnaird, Abigail L.

Abstract

John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization.

Citation

Arkill, K. P., Michel, C. C., Rider, E. V. M., Wood, E. A., Small, M. O., Brown, J. L. E., & Kinnaird, A. L. (2023). John squire and endothelial glycocalyx structure: an unfinished story. Journal of Muscle Research and Cell Motility, 44(3), 217-223. https://doi.org/10.1007/s10974-022-09629-x

• Journal Article Type: Article
• Acceptance Date: Aug 23, 2022
• Online Publication Date: Oct 19, 2022
• Publication Date: Sep 1, 2023
• Deposit Date: Oct 25, 2022
• Publicly Available Date: Oct 26, 2022
• Journal: Journal of Muscle Research and Cell Motility
• Print ISSN: 0142-4319
• Electronic ISSN: 1573-2657
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 44
• Issue: 3
• Pages: 217-223
• DOI: https://doi.org/10.1007/s10974-022-09629-x
• Keywords: Cell Biology; Biochemistry; Physiology
• Public URL: https://nottingham-repository.worktribe.com/output/12624613
• Publisher URL: https://link.springer.com/article/10.1007/s10974-022-09629-x