Outputs (5)

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics (2019)
Journal Article
Bradley, C. R., Bragg, D. D., Cox, E. F., El-Sharkawy, A. M., Buchanan, C. E., Chowdhury, A. H., …Lobo, D. N. (2020). A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics. Clinical Nutrition, 39(7), 2070-2079. https://doi.org/10.1016/j.clnu.2019.09.011

Background & aims
Blood volume expanding properties of colloids are superior to crystalloids. In addition to oncotic/osmotic properties, the electrolyte composition of infusions may have important effects on visceral perfusion, with infusions contai... Read More about A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics.

Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI (2016)
Journal Article
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Cox, E., Hoad, C., Pritchard, S. E., Gowland, P. A., & Spiller, R. C. (in press). Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI. American Journal of Gastroenterology, https://doi.org/10.1038/ajg.2016.538

OBJECTIVES: Non-invasive biomarkers which identify different mechanisms of disease in subgroups of irritable bowel syndrome (IBS) could be valuable. Our aim was to seek useful magnetic resonance imaging (MRI) parameters that could distinguish each IB... Read More about Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI.

Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging (2016)
Journal Article
Palaniyappan, N., Cox, E., Bradley, C., Scott, R., Austin, A., O’Neill, R., Ramjas, G., Travis, S., White, H., Singh, R., Thurley, P., Guha, I. N., Francis, S., & Aithal, G. P. (2016). Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging. Journal of Hepatology, 65(6), 1131-1139. https://doi.org/10.1016/j.jhep.2016.07.021

Background & Aims

Hepatic venous pressure gradient (HVPG) measurement is currently the only validated technique to accurately evaluate changes in portal pressure. In this study, we evaluate the use of non-contrast quantitative magnetic resonance i... Read More about Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging.

Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI (2014)
Journal Article
Murray, K., Wilkinson-Smith, V., Hoad, C., Costigan, C., Cox, E., Lam, C., …Spiller, R. C. (2014). Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI. American Journal of Gastroenterology, 109(1), 110-119. https://doi.org/10.1038/ajg.2013.386

OBJECTIVES:The objective of this study was to investigate whether ingestion of fructose and fructans (such as inulin) can exacerbate irritable bowel syndrome (IBS) symptoms. The aim was to better understand the origin of these symptoms by magnetic re... Read More about Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI.