Outputs (15)

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation (2019)
Journal Article
Vara-Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K. M., Atrih, A., Foretz, M., …Hardie, D. G. (2019). Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation. Cell Reports, 27(3), 690-698.e4. https://doi.org/10.1016/j.celrep.2019.03.067

AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has
been associated with reduced cancer risk. However... Read More about Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.

Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review (2019)
Journal Article
Sousa, L., Chadborn, N. H., Goodman, C., Zubair, M., Sousa, L., Gladman, J. R. F., …Gordon, A. L. (2019). Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review. BMJ Open, 9(4), 1-9. https://doi.org/10.1136/bmjopen-2018-026921

Objectives
Comprehensive Geriatric Assessment (CGA) may be a way to deliver optimal care for care home residents. We used realist review to develop a theory-driven account of how CGA works in care homes.

Design
Realist review

Setting
Care ho... Read More about Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review.

Day of the week to tweet: a randomised controlled trial (2019)
Journal Article
Jayaram, M., Adams, C. E., Friedel, J. S., Mcclenaghan, E., Montgomery, A. A., Välimäki, M., …Zhao, S. (2019). Day of the week to tweet: a randomised controlled trial. BMJ Open, 9(4), Article e025380. https://doi.org/10.1136/bmjopen-2018-025380

Objective: To assess the effects of using health social media on different days of the working week on web activity.
Design: Individually randomised controlled parallel group superiority trial.
Setting: Twitter and Weibo.
Participants: 194 Cochran... Read More about Day of the week to tweet: a randomised controlled trial.

Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents (2019)
Journal Article
Alvaradejo, G. G., Nguyen, H. V.-T., Harvey, P., Gallagher, N. M., Le, D., Ottaviani, M. F., …Johnson, J. A. (2019). Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents. ACS Macro Letters, 8(4), 473-478. https://doi.org/10.1021/acsmacrolett.9b00016

Copyright © 2019 American Chemical Society. The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-... Read More about Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents.

Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss (2019)
Journal Article
Heffernan, E., Habib, A., & Ferguson, M. (2019). Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss. International Journal of Audiology, 58(1), 45-52. https://doi.org/10.1080/14992027.2018.1533257

This study aimed to evaluate the psychometric properties of a brief, hearing-specific outcome measure: the Social Isolation Measure (SIM). In Phase 1, adults with hearing loss were invited to complete an online survey that contained the SIM, a hearin... Read More about Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss.