Outputs (44)

The genetics of pre-eclampsia and other hypertensive disorders of pregnancy (2011)
Journal Article
Williams, P. J., & Broughton Pipkin, F. (2011). The genetics of pre-eclampsia and other hypertensive disorders of pregnancy. Best Practice and Research: Clinical Obstetrics and Gynaecology, 25(4), https://doi.org/10.1016/j.bpobgyn.2011.02.007

Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia... Read More about The genetics of pre-eclampsia and other hypertensive disorders of pregnancy.

Both, toxin A and toxin B, are important in Clostridium difficile infection (2011)
Journal Article
Kuehne, S. A., Cartman, S. T., & Minton, N. P. (2011). Both, toxin A and toxin B, are important in Clostridium difficile infection. Gut Microbes, 2(4), https://doi.org/10.4161/gmic.2.4.16109

The bacterium Clostridium difficile is the leading cause of healthcare associated diarrhoea in the developed world and thus presents a major financial burden. The main virulence factors of C. difficile are two large toxins, A and B. Over the years th... Read More about Both, toxin A and toxin B, are important in Clostridium difficile infection.

Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy (2011)
Journal Article
Williams, P. J., Bulmer, J. N., Innes, B. A., & Broughton Pipkin, F. (2011). Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy. Biology of Reproduction, 84(6), https://doi.org/10.1095/biolreprod.110.088351

In addition to its role in the prevention of neural tube defects, folic acid has many other physiological functions, including cell proliferation, DNA replication, and antioxidant protection. The aim of this study was to determine the role that folic... Read More about Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy.

Density-dependent fitness benefits in quorum-sensing bacterial populations
Journal Article
Darch, S. E., West, S. A., Winzer, K., & Diggle, S. P. Density-dependent fitness benefits in quorum-sensing bacterial populations. Proceedings of the National Academy of Sciences, 109(21), https://doi.org/10.1073/pnas.1118131109

It has been argued that bacteria communicate using small diffusible signal molecules to coordinate, among other things, the production of factors that are secreted outside of the cells in a process known as quorum sensing (QS). The underlying assumpt... Read More about Density-dependent fitness benefits in quorum-sensing bacterial populations.