Outputs (44)

Bacterial cooperation in the wild and in the clinic: are pathogen social behaviours relevant outside the laboratory? (2013)
Journal Article
Harrison, F. (2013). Bacterial cooperation in the wild and in the clinic: are pathogen social behaviours relevant outside the laboratory?. BioEssays, 35(2), https://doi.org/10.1002/bies.201200154

Individual bacterial cells can communicate via quorum sensing, cooperate to harvest nutrients from their environment, form multicellular biofilms, compete over resources and even kill one another. When the environment that bacteria inhabit is an anim... Read More about Bacterial cooperation in the wild and in the clinic: are pathogen social behaviours relevant outside the laboratory?.

A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium (2012)
Journal Article
Safuan, S., Storr, S. J., Patel, P. M., & Martin, S. G. (2012). A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium. Lymphatic Research and Biology, 10(4), https://doi.org/10.1089/lrb.2012.0007

Background: Lymphovascular invasion (LVI) is an important step in the metastatic cascade; tumor cell migration
and adhesion to blood and lymphatic vessels is followed by invasion through the vessel wall and subsequent
systemic spread. Although prim... Read More about A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium.

Quorum-sensing and cheating in bacterial biofilms (2012)
Journal Article
Popat, R., Crusz, S. A., Messina, M., Willams, P., West, S. A., & Diggle, S. P. (2012). Quorum-sensing and cheating in bacterial biofilms. Proceedings of the Royal Society B: Biological Sciences, 279(1748), https://doi.org/10.1098/rspb.2012.1976

The idea from human societies that self-interest can lead to a breakdown of cooperation at the group level
is sometimes termed the public goods dilemma. We tested this idea in the opportunistic bacterial pathogen,
Pseudomonas aeruginosa, by examini... Read More about Quorum-sensing and cheating in bacterial biofilms.

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla (2012)
Journal Article
Storr, S. J., Zaitoun, A. M., Arora, A., Durrant, L. G., Lobo, D. N., Madhusudan, S., & Martin, S. G. (2012). Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla. BMC Cancer, 12(511), https://doi.org/10.1186/1471-2407-12-511

Background: Pancreatic cancer, including cancer of the ampulla of Vater and bile duct, is very aggressive and has a
poor five year survival rate; improved methods of patient stratification are required.
Methods: We assessed the expression of calpai... Read More about Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla.

Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer (2012)
Journal Article
Storr, S. J., Safuan, S., Woolston, C. M., Abdel-Fatah, T., Deen, S., Chan, S. Y., & Martin, S. G. (2012). Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. Journal of Cellular and Molecular Medicine, 16(10), https://doi.org/10.1111/j.1582-4934.2012.01559.x

Ovarian cancer is routinely treated with surgery and platinum-based chemotherapy. Resistance is a major obstacle in the efficacy of this chemotherapy
regimen and the ability to identify those patients at risk of developing resistance is of considera... Read More about Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.

Calpain system protein expression in basal-like and triple-negative invasive breast cancer (2012)
Journal Article
triple-negative invasive breast cancer. Annals of Oncology, 23(9), https://doi.org/10.1093/annonc/mds176

Background: Basal-like and triple-negative breast tumours encompass an important clinical subgroup and
biomarkers that can prognostically stratify these patients are required.
Materials and methods: We investigated two breast cancer tissue microarr... Read More about Calpain system protein expression in basal-like and triple-negative invasive breast cancer.

Kin selection, quorum sensing and virulence in pathogenic bacteria (2012)
Journal Article
Rumbaugh, K. P., Trivedi, U., Watters, C., Burton-Chellew, M. N., Diggle, S. P., & West, S. A. (2012). Kin selection, quorum sensing and virulence in pathogenic bacteria. Proceedings of the Royal Society B: Biological Sciences, 279(1742), https://doi.org/10.1098/rspb.2012.0843

Bacterial growth and virulence often depends upon the cooperative release of extracellular factors excreted in
response to quorum sensing (QS).We carried out an in vivo selection experiment in mice to examine how QS
evolves in response to variation... Read More about Kin selection, quorum sensing and virulence in pathogenic bacteria.

A novel virulence strategy for Pseudomonas aeruginosa mediated by an autotransporter with arginine-specific aminopeptidase activity (2012)
Journal Article
Luckett, J., Darch, O., Watters, C., AbuOun, M., Wright, V., Paredes-Osses, E., Ward, J., Goto, H., Heeb, S., Pommier, S., Rumbaugh, K. P., Cámara, M., & Hardie, K. R. (2012). A novel virulence strategy for Pseudomonas aeruginosa mediated by an autotransporter with arginine-specific aminopeptidase activity. PLoS Pathogens, 8(8), Article e1002854. https://doi.org/10.1371/journal.ppat.1002854

The opportunistic human pathogen, Pseudomonas aeruginosa, is a major cause of infections in chronic wounds, burns and the lungs of cystic fibrosis patients. The P. aeruginosa genome encodes at least three proteins exhibiting the characteristic three... Read More about A novel virulence strategy for Pseudomonas aeruginosa mediated by an autotransporter with arginine-specific aminopeptidase activity.

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C.-Y., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei, Y., Bayston, R., Irvine, D. J., Langer, R., Anderson, D. G., Williams, P., Davies, M. C., & Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), 868-875. https://doi.org/10.1038/nbt.2316

Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput... Read More about Combinatorial discovery of polymers resistant to bacterial attachment.

Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy (2012)
Journal Article
Fareed, K. R., Soomro, I. N., Hameed, K., Arora, A., Lobo, D. N., Parsons, S. L., & Madhusudan, S. (2012). Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy. World Journal of Gastroenterology, 18(16), https://doi.org/10.3748/wjg.v18.i16.1915

AIM: To examine cytokeratin-18 (CK-18) and caspase-cleaved CK-18 expression in tumours and correlate with clinicopathological outcomes including tumour regression grade (TRG) response.

METHODS: Formalin-fixed human gastro-oesophageal cancers were... Read More about Caspase-cleaved cytokeratin-18 and tumour regression in gastro-oesophageal adenocarcinomas treated with neoadjuvant chemotherapy.