Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study (2024)
Journal Article
Kalenderski, K., Dubern, J.-F., Lewis-Lloyd, C., Jeffery, N., Heeb, S., Irvine, D. J., …Williams, P. (2024). Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study. Journal of Urology Open PLus, 2(1), Article e00005. https://doi.org/10.1097/JU9.0000000000000097

Purpose: Biofilm formation and biomineralization on urinary catheters may cause severe complications including infection and obstruction. Here, we describe an in vitro evaluation and prospective pilot clinical study of a silicone catheter coated with... Read More about Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study.

A systematic literature review and meta-analysis on digital health interventions for people living with dementia and Mild Cognitive Impairment (2022)
Journal Article
Di Lorito, C., Bosco, A., Rai, H., Craven, M., McNally, D., Todd, C., …Harwood, R. H. (2022). A systematic literature review and meta-analysis on digital health interventions for people living with dementia and Mild Cognitive Impairment. International Journal of Geriatric Psychiatry, 37(6), https://doi.org/10.1002/gps.5730

Objectives: Digital health interventions enable services to support people living with dementia and Mild Cognitive Impairment (MCI) remotely. This literature review gathers evidence on the effectiveness of digital health interventions on physical, co... Read More about A systematic literature review and meta-analysis on digital health interventions for people living with dementia and Mild Cognitive Impairment.

Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network (2021)
Journal Article
Ifesemen, O. S., McWilliams, D. F., Norton, S., Kiely, P. D. W., Young, A., & Walsh, D. A. (2022). Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network. Rheumatology, 61(9), 3737-3745. https://doi.org/10.1093/rheumatology/keab947

OBJECTIVES: Fatigue is a disabling symptom in people with RA. This study aims to describe the prevalence, risk factors and longitudinal course of fatigue in early RA. METHODS: Demographic, clinical, quality of life (QoL), comorbidities and laboratory... Read More about Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network.

Feasibility RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during periods of Immobility (IMMI): Protocol (2021)
Preprint / Working Paper
Gladman, J., Aloraibi, S., Greenhaff, P., Piasecki, M., Phillips, B., Atherton, P., …Gordon, A. Feasibility RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during periods of Immobility (IMMI): Protocol

East Midlands Research into Ageing Network (EMRAN) is a research collaboration across the East Midlands to facilitate collaborative applied clinical research into ageing and the care of older people. EMRAN was set up by NIHR CLAHRC East Midlands and... Read More about Feasibility RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during periods of Immobility (IMMI): Protocol.

Effects of neuromuscular electrical stimulation (NMES) in acutely hospitalised adult patients -protocol for a systematic review of randomised controlled trials (RCTs) (2021)
Preprint / Working Paper
Alqurashi, H., Robinson, K., Gladman, J., Gordon, A., Masud, T., & Piasecki, M. (2021). Effects of neuromuscular electrical stimulation (NMES) in acutely hospitalised adult patients -protocol for a systematic review of randomised controlled trials (RCTs)

The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis (2021)
Journal Article
McWilliams, D. F., Thankaraj, D., Jones-Diette, J., Morgan, R., Ifesemen, O. S., Shenker, N. G., & Walsh, D. A. (2022). The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis. Rheumatology, 61(1), 76-89. https://doi.org/10.1093/rheumatology/keab503

Objectives: Glucocorticosteroids (GCs) are recommended to suppress inflammation in people with active RA. This systematic review and meta-analysis aimed to quantify the effects of systemic GCs on RA pain. Methods: A systematic literature review of ra... Read More about The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis.

“A little (PPI) MAGIC can take you a long way” : involving children and young people in research from inception of a novel medical device to multi-centre clinical trial Roald Dahl, James and the Giant Peach (1961) (2021)
Journal Article
Abrehart, N., Frost, K., YPAG, Y. P. A. G., Harris, R., Wragg, A., Stewart, D., …Marciani, L. (2021). “A little (PPI) MAGIC can take you a long way” : involving children and young people in research from inception of a novel medical device to multi-centre clinical trial Roald Dahl, James and the Giant Peach (1961). Research Involvement and Engagement, 7, Article 2. https://doi.org/10.1186/s40900-020-00243-0

Background: There is often a great urgency to be inclusive when conducting research and to focus efforts with groups and communities that can be referred to as marginalised. This is especially the case in research concerning medical devices aimed a... Read More about “A little (PPI) MAGIC can take you a long way” : involving children and young people in research from inception of a novel medical device to multi-centre clinical trial Roald Dahl, James and the Giant Peach (1961).

Interventions to ameliorate reductions in muscle quantity and function in hospitalised older adults: a systematic review towards acute sarcopenia treatment (2020)
Journal Article
John, G., Welsh, C., Majid, Z., Masud, T., Jackson, T., & Grieg, C. (2021). Interventions to ameliorate reductions in muscle quantity and function in hospitalised older adults: a systematic review towards acute sarcopenia treatment. Age and Ageing, 50(2), 394-404. https://doi.org/10.1093/ageing/afaa209

Objective: Assimilate evidence for interventions to ameliorate negative changes in physical performance, muscle strength, and muscle quantity in hospitalised older adults.

Methods: We searched for articles using MEDLINE, Embase, CINAHL, and Cochr... Read More about Interventions to ameliorate reductions in muscle quantity and function in hospitalised older adults: a systematic review towards acute sarcopenia treatment.

Essential guide to acute care (2020)
Book
Cooper, N., Cramp, P., Forrest, K., & Patel, R. (2020). Essential guide to acute care. (3rd edition). London: Wiley

The best-selling Essential Guide to Acute Care contains everything you need to know about acute care that you can’t find in a standard textbook. The third edition has been extensively revised and updated, presenting new oxygen guidelines, updated evi... Read More about Essential guide to acute care.

Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation (2020)
Journal Article
Sharif, H., Abrehart, N., Hoad, C., Murray, K., Perkins, A., Smith, M., …Marciani, L. (2020). Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation. Journal of Pediatric Gastroenterology and Nutrition, 71(5), 604-611. https://doi.org/10.1097/MPG.0000000000002910

Objective: In England, 27,500 children are referred annually to hospital with constipation. An objective measure of whole gut transit time (WGTT) could aid management. The current standard WGTT assessment, the X-ray radiopaque marker (ROM) test, give... Read More about Feasibility Study of a New MRI Mini-Capsule Device to Measure Whole Gut Transit Time in Pediatric Constipation.

Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era (2020)
Journal Article
Lawrence, R. J., O'Donoghue, G., Kitterick, P., O'Donoghue, K., Hague, R., Mitchell, L., …Hartley, D. E. (2020). Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era. Laryngoscope, 130(11), 2693-2699. https://doi.org/10.1002/lary.29014

© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA) Objectives/Hypothesis: The overall aim of this study was to evaluate personal protective equipment (PPE)... Read More about Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era.

Investigating musculoskeletal health and wellbeing; A cohort study protocol (2020)
Journal Article
Millar, B., McWilliams, D. F., Abhishek, A., Akin-Akinyosoye, K., Auer, D. P., Chapman, V., …Walsh, D. A. (2020). Investigating musculoskeletal health and wellbeing; A cohort study protocol. BMC Musculoskeletal Disorders, 21(1), Article 182. https://doi.org/10.1186/s12891-020-03195-4

© 2020 The Author(s). Background: In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal Heal... Read More about Investigating musculoskeletal health and wellbeing; A cohort study protocol.

PAIN AND FATIGUE IN EARLY RHEUMATOID ARTHRITIS - A CROSS-SECTIONAL STUDY (2019)
Presentation / Conference Contribution
Ifesemen, O., McWilliams, D., Young, A., Kiely, P., & Walsh, D. (2019, September). PAIN AND FATIGUE IN EARLY RHEUMATOID ARTHRITIS - A CROSS-SECTIONAL STUDY. Poster presented at 11th Congress of the European Pain Federation EFIC, Valencia, Spain

O.S. Ifesemen, D.F. McWilliams, A. Young, P.D.W. Kiely, D.A. Walsh
Background and Aims

Pain and fatigue are prevalent and impair quality of life in people with Rheumatoid Arthritis (RA). They might be caused by multiple and overlapping mechanis... Read More about PAIN AND FATIGUE IN EARLY RHEUMATOID ARTHRITIS - A CROSS-SECTIONAL STUDY.

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma (2019)
Journal Article
Sabnis, D. H., Storer, L. C. D., Liu, J., Jackson, H. K., Kilday, J. P., Grundy, R. G., …Coyle, B. (2019). A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma. Scientific Reports, 9(1), 1-9. https://doi.org/10.1038/s41598-019-46700-z

© 2019, The Author(s). Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasion and recurrence. We hypothesised that these hallmarks were due to the presence of a sub-population of cancer stem cells expres... Read More about A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma.

Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study (2019)
Journal Article
Du, L., Wenning, L. A., Carvalho, B., Duley, L., Brookfield, K. F., Witjes, H., …Oladapo, O. T. (2019). Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study. Journal of Clinical Pharmacology, 59(11), 1519-1526. https://doi.org/10.1002/jcph.1448

Magnesium sulfate is the anticonvulsant of choice for eclampsia prophylaxis and treatment; however, the recommended dosing regimens are costly and cumbersome and can be administered only by skilled health professionals. The objectives of this study w... Read More about Alternative Magnesium Sulfate Dosing Regimens for Women With Preeclampsia: A Population Pharmacokinetic Exposure-Response Modeling and Simulation Study.

Study-based registers reduce waste in systematic reviewing: discussion and case report (2019)
Journal Article
Shokraneh, F., & Adams, C. E. (2019). Study-based registers reduce waste in systematic reviewing: discussion and case report. Systematic Reviews, 8(1), Article 129. https://doi.org/10.1186/s13643-019-1035-3

Background
Maintained study-based registers (SBRs) have, at their core, study records linked to, potentially, multiple other records such as references, data sets, standard texts and full-text reports. Such registers can minimise and refine searchin... Read More about Study-based registers reduce waste in systematic reviewing: discussion and case report.

Effects of tinnitus on cochlear implant programming (2019)
Journal Article
Pierzycki, R. H., Corner, C., Fielden, C. A., & Kitterick, P. T. (2019). Effects of tinnitus on cochlear implant programming. Trends in Hearing, 23, https://doi.org/10.1177/2331216519836624

Clinical observations suggest that tinnitus may interfere with programming cochlear implants (CIs), the process of optimizing the transmission of acoustic information to support speech perception with a CI. Despite tinnitus being highly prevalent amo... Read More about Effects of tinnitus on cochlear implant programming.

Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses (2019)
Journal Article
Ovadia, C., Seed, P. T., Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J., …Williamson, C. (2019). Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet, 393(10174), 899-909. https://doi.org/10.1016/s0140-6736%2818%2931877-4

Background
Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic... Read More about Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses.

Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema (2019)
Journal Article
Howells, L., Thomas, K. S., Sears, A. V., Nasr, I., Wollenberg, A., Schuttelaar, M. L., …Chalmers, J. R. (2019). Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema. Journal of the European Academy of Dermatology and Venereology, 33(6), 1124-1132. https://doi.org/10.1111/jdv.15475

Background: Atopic eczema (also known as eczema) is a chronic, inflammatory skin condition that often afflicts patients’ health and wellbeing. The Harmonising Outcome Measures for Eczema (HOME) initiative recommends that “long-term control of eczema”... Read More about Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema.

Glutamate dehydrogenase (GLUD1) expression in breast cancer (2018)
Journal Article
Craze, M. L., El-Ansari, R., Aleskandarany, M. A., Cheng, K. W., Al-Farsi, L., Masisi, B., …Green, A. R. (2019). Glutamate dehydrogenase (GLUD1) expression in breast cancer. Breast Cancer Research and Treatment, 174(1), 79–91. https://doi.org/10.1007/s10549-018-5060-z

Dysregulated cellular metabolism is regarded as one of the hallmarks of cancer with some tumours utilising the glutamine metabolism pathway for their sustained proliferation and survival. Glutamate dehydrogenase (GLUD1) is a key enzyme in glutaminoly... Read More about Glutamate dehydrogenase (GLUD1) expression in breast cancer.