Outputs (16)

Studying neuroanatomy using MRI (2017)
Journal Article
Lerch, J. P., van der Kouwe, A. J., Raznahan, A., Paus, T., Johansen-Berg, H., Miller, K. L., …Sotiropoulos, S. N. (in press). Studying neuroanatomy using MRI. Nature Neuroscience, 20(3), https://doi.org/10.1038/nn.4501

The study of neuroanatomy using imaging enables key insights into how our brains function, are shaped by genes and environment, and change with development, aging, and disease. Developments in MRI acquisition, image processing, and data modelling hav... Read More about Studying neuroanatomy using MRI.

Image quality transfer and applications in diffusion MRI (2017)
Journal Article
Alexander, D. C., Zikic, D., Ghosh, A., Tanno, R., Wottschel, V., Zhang, J., …Criminisi, A. (2017). Image quality transfer and applications in diffusion MRI. NeuroImage, 152, https://doi.org/10.1016/j.neuroimage.2017.02.089

This paper introduces a new computational imaging technique called image quality transfer (IQT). IQT uses machine learning to transfer the rich information available from one-off experimental medical imaging devices to the abundant but lower-quality... Read More about Image quality transfer and applications in diffusion MRI.

Building connectomes using diffusion MRI: why, how and but (2017)
Journal Article
Sotiropoulos, S. N., & Zalesky, A. (in press). Building connectomes using diffusion MRI: why, how and but. NMR in Biomedicine, https://doi.org/10.1002/nbm.3752

Why has diffusion MRI become a principal modality for mapping connectomes in vivo? How do different image acquisition parameters, fiber tracking algorithms and other methodological choices affect connectome estimation? What are the main factors that... Read More about Building connectomes using diffusion MRI: why, how and but.

The heritability of multi-modal connectivity in human brain activity (2017)
Journal Article
Colclough, G. L., Smith, S. M., Nichols, T. E., Winkler, A. M., Sotiropoulos, S. N., Glasser, M. F., …Woolrich, M. W. (in press). The heritability of multi-modal connectivity in human brain activity. eLife, 6, Article e20178. https://doi.org/10.7554/eLife.20178

Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and... Read More about The heritability of multi-modal connectivity in human brain activity.

Evaluating fibre orientation dispersion in white matter: comparison of diffusion MRI, histology and polarized light imaging (2017)
Journal Article
Mollink, J., Kleinnijenhuis, M., Cappellen van Walsum, A.-M. V., Sotiropoulos, S. N., Cottaar, M., Mirfin, C., …Miller, K. L. (2017). Evaluating fibre orientation dispersion in white matter: comparison of diffusion MRI, histology and polarized light imaging. NeuroImage, 157, https://doi.org/10.1016/j.neuroimage.2017.06.001

Diffusion MRI is an exquisitely sensitive probe of tissue microstructure, and is currently the only non-invasive measure of the brain’s fibre architecture. As this technique becomes more sophisticated and microstructurally informative, there is incre... Read More about Evaluating fibre orientation dispersion in white matter: comparison of diffusion MRI, histology and polarized light imaging.

Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank (2017)
Journal Article
Alfaro-Almagro, F., Jenkinson, M., Bangerter, N. K., Andersson, J. L., Griffanti, L., Douaud, G., …Smith, S. M. (2018). Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank. NeuroImage, 166, https://doi.org/10.1016/j.neuroimage.2017.10.034

UK Biobank is a large-scale prospective epidemiological study with all data accessible to researchers worldwide. It is currently in the process of bringing back 100,000 of the original participants for brain, heart and body MRI, carotid ultrasound an... Read More about Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank.

A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks (2018)
Journal Article
Abeysuriya, R. G., Hadida, J., Sotiropoulos, S. N., Jbabdi, S., Becker, R., Hunt, B. A., …Woolrich, M. W. (in press). A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks. PLoS Computational Biology, 14(2), Article e1006007. https://doi.org/10.1371/journal.pcbi.1006007

Over long timescales, neuronal dynamics can be robust to quite large perturbations, such as changes in white matter connectivity and grey matter structure through processes including learning, aging, development and certain disease processes. One pos... Read More about A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks.

Moving magnetoencephalography towards real-world applications with a wearable system (2018)
Journal Article
Boto, E., Holmes, N., Leggett, J., Roberts, G., Shah, V., Meyer, S. S., …Brookes, M. J. (2018). Moving magnetoencephalography towards real-world applications with a wearable system. Nature, 555, 657-661. https://doi.org/10.1038/nature26147

Imaging human brain function with techniques such as magnetoencephalography1 (MEG) typically requires a subject to perform tasks whilst their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessibl... Read More about Moving magnetoencephalography towards real-world applications with a wearable system.

Quantifying MRI frequency shifts due to structures with anisotropic magnetic susceptibility using pyrolytic graphite sheet (2018)
Journal Article
Cronin, M., & Bowtell, R. W. (2018). Quantifying MRI frequency shifts due to structures with anisotropic magnetic susceptibility using pyrolytic graphite sheet. Scientific Reports, 8, Article 6259. https://doi.org/10.1038/s41598-018-24650-2

Magnetic susceptibility is an important source of contrast in magnetic resonance imaging (MRI), with spatial variations in the susceptibility of tissue affecting both the magnitude and phase of the measured signals. This contrast has generally been i... Read More about Quantifying MRI frequency shifts due to structures with anisotropic magnetic susceptibility using pyrolytic graphite sheet.

Whole brain comparative anatomy using connectivity blueprints (2018)
Journal Article
Mars, R. B., Sotiropoulos, S. N., Passingham, R. E., Sallet, J., Verhagen, L., Khrapitchev, A. A., …Jbabdi, S. (in press). Whole brain comparative anatomy using connectivity blueprints. eLife, 7, Article e35237. https://doi.org/10.7554/eLife.35237

Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primat... Read More about Whole brain comparative anatomy using connectivity blueprints.

Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI (2018)
Journal Article
Schwarz, S. T., Mougin, O., Xing, Y., Blazejewska, A., Bajaj, N., Auer, D. P., & Gowland, P. (2018). Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI. NeuroImage: Clinical, 19, 683-689. https://doi.org/10.1016/j.nicl.2018.05.027

Improved markers for the progression of Parkinson's disease (PD) are required. Previous work has proven that iron dependent MRI scans can detect the largest Nigrosome (N1) within the substantia nigra (SN) pars compacta and changes in PD. Histopatholo... Read More about Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI.

Bayesian optimization of large-scale biophysical networks (2018)
Journal Article
Hadida, J., Sotiropoulos, S. N., Abeysuriya, R. G., Woolrich, M. W., & Jbabdi, S. (2018). Bayesian optimization of large-scale biophysical networks. NeuroImage, 174, https://doi.org/10.1016/j.neuroimage.2018.02.063

The relationship between structure and function in the human brain is well established, but not yet well characterised. Large-scale biophysical models allow us to investigate this relationship, by leveraging structural information (e.g. derived from... Read More about Bayesian optimization of large-scale biophysical networks.

Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations (2018)
Journal Article
Garcia-Gonzalez, D., Race, N. S., Voets, N. L., Jenkins, D. R., Sotiropoulos, S. N., Acosta, G., …Jérusalem, A. (in press). Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations. Scientific Reports, 8, Article 10273. https://doi.org/10.1038/s41598-018-28271-7

Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears to be important, the specific mechanistic causes of such disorders remain elusive... Read More about Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations.

Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function (2018)
Journal Article
Tierney, T. M., Holmes, N., Meyer, S. S., Boto, E., Roberts, G., Leggett, J., …Barnes, G. R. (2018). Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function. NeuroImage, 181, 513-520. https://doi.org/10.1016/j.neuroimage.2018.07.035

Recent work has demonstrated that Optically Pumped Magnetometers (OPMs) can be utilised to create a wearable Magnetoencephalography (MEG) system that is motion robust. In this study, we use this system to map eloquent cortex using a clinically valida... Read More about Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function.

A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography (2018)
Journal Article
Holmes, N., Leggett, J., Boto, E., Roberts, G., Hill, R. M., Tierney, T. M., …Bowtell, R. (2018). A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography. NeuroImage, 181, 760-774. https://doi.org/10.1016/j.neuroimage.2018.07.028

Small, commercially-available Optically Pumped Magnetometers (OPMs) can be used to construct a wearable Magnetoencephalography (MEG) system that allows large head movements to be made during recording. The small dynamic range of these sensors however... Read More about A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography.

Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson’s disease (2017)
Journal Article
Akram, H., Sotiropoulos, S. N., Jbabdi, S., Georgiev, D., Mahlknecht, P., Hyam, J., …Zrinzo, L. (2017). Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson’s disease. NeuroImage, 158, https://doi.org/10.1016/j.neuroimage.2017.07.012

Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and secondly, to map-out the cortical fingerprint, mediated by the hyperdire... Read More about Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson’s disease.