Ms RAQUEL MESQUITA RIBEIRO's Outputs (7)

Total synthesis, biological evaluation and biosynthetic re-evaluation of Illicium-derived neolignans (2024)
Journal Article
Arnold, R. E., Saska, J., Mesquita-Ribeiro, R., Dajas-Bailador, F., Taylor, L., Lewis, W., Argent, S., Shao, H., Houk, K. N., & Denton, R. M. (2024). Total synthesis, biological evaluation and biosynthetic re-evaluation of Illicium-derived neolignans. Chemical Science, 15(30), 11783-11793. https://doi.org/10.1039/d4sc03232b

We report the first total syntheses of simonsol F (3), simonsinol (5), fargenin (4), and macranthol (6) in addition to syntheses of simonsol C (2), simonsol G (1), and honokiol (14). The syntheses are based upon a phosphonium ylide-mediated cascade r... Read More about Total synthesis, biological evaluation and biosynthetic re-evaluation of Illicium-derived neolignans.

A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles (2024)
Journal Article
White, K. E., Bailey, H. L., Shaw, B. S., Geiszler, P. C., Mesquita-Ribeiro, R., Scott, D., Layfield, R., & Serres, S. (2024). A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles. Frontiers in Cellular Neuroscience, 18, Article 1414142. https://doi.org/10.3389/fncel.2024.1414142

Extracellular vesicles (EVs) are secreted by all cells in the CNS, including neurons and astrocytes. EVs are lipid membrane enclosed particles loaded with various bioactive cargoes reflecting the dynamic activities of cells of origin. In contrast to... Read More about A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles.

Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice (2022)
Journal Article
Diaz-Amarilla, P., Arredondo, F., Dapueto, R., Boix, V., Carvalho, D., Santi, M. D., Vasilskis, E., Mesquita-Ribeiro, R., Dajas-Bailador, F., Abin-Carriquiry, J. A., Engler, H., & Savio, E. (2022). Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice. Neurochemistry International, 159, Article 105403. https://doi.org/10.1016/j.neuint.2022.105403

Alzheimer's disease has been considered mostly as a neuronal pathology, although increasing evidence suggests that glial cells might play a key role in the disease onset and progression. In this sense, astrocytes, with their central role in neuronal... Read More about Isolation and characterization of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice.

Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves (2021)
Journal Article
Mesquita-Ribeiro, R., Fort, R. S., Rathbone, A., Farias, J., Lucci, C., James, V., Sotelo-Silveira, J., Duhagon, M. A., & Dajas-Bailador, F. (2021). Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves. RNA Biology, 18(sup2), 832-855. https://doi.org/10.1080/15476286.2021.2000792

Neurons have highlighted the needs for decentralized gene expression and specific RNA function in somato-dendritic and axonal compartments, as well as in intercellular communication via extracellular vesicles (EVs). Despite advances in miRNA biology,... Read More about Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves.

PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses (2020)
Journal Article
Di Paolo, A. P., Eastman, G., Mesquita Ribeiro, R., Farias, J., Macklin, A., Kislinger, T., Colburn, N., Munroe, D., Sotelo Sosa, J. R., Dajas Bailador, F., & Sotelo Silveira, J. R. (2020). PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses. RNA, 26(11), 1637-1653. https://doi.org/10.1261/rna.075424.120

© 2020 Di Paolo et al. Programmed cell death 4 (PDCD4) protein is a tumor suppressor that inhibits translation through the mTOR-dependent initiation factor EIF4A, but its functional role and mRNA targets in neurons remain largely unknown. Our work id... Read More about PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.

Self-activated photoblinking of nitrogen vacancy centers in nanodiamonds (sandSTORM): A method for rapid single molecule localization microscopy with unlimited observation time (2020)
Preprint / Working Paper
Narayanasamy, K. K., Price, J. C., Mesquita-Riberio, R., Mather, M. L., & Jayasinghe, I. Self-activated photoblinking of nitrogen vacancy centers in nanodiamonds (sandSTORM): A method for rapid single molecule localization microscopy with unlimited observation time

Stochastic optical reconstruction microscopy (STORM) is one of the most commonly used super-resolution microscopy techniques. Popular implementations of STORM utilize aromatic fluorophores and consist of a number of intrinsic limitations such the fin... Read More about Self-activated photoblinking of nitrogen vacancy centers in nanodiamonds (sandSTORM): A method for rapid single molecule localization microscopy with unlimited observation time.

Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons (2020)
Journal Article
Lucci, C., Mesquita-Ribeiro, R., Rathbone, A., & Dajas-Bailador, F. (2020). Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons. Development, 147(3), Article dev180232. https://doi.org/10.1242/dev.180232

© 2020. Published by The Company of Biologists Ltd. Both the establishment of neuronal polarity and axonal growth are crucial steps in the development of the nervous system. The local translation of mRNAs in the axon provides precise regulation of pr... Read More about Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons.