Professor DOV STEKEL's Outputs (4)

INfrastructure for a PHAge REference Database: Identification of Large-Scale Biases in the Current Collection of Cultured Phage Genomes (2021)
Journal Article
Cook, R., Brown, N., Redgwell, T., Rihtman, B., Barnes, M., Clokie, M., Stekel, D. J., Hobman, J., Jones, M. A., & Millard, A. (2021). INfrastructure for a PHAge REference Database: Identification of Large-Scale Biases in the Current Collection of Cultured Phage Genomes. PHAGE Therapy, Applications, and Research, 2(4), 214-223. https://doi.org/10.1089/phage.2021.0007

Background: With advances in sequencing technology and decreasing costs, the number of phage genomes that have been sequenced has increased markedly in the past decade. Materials and Methods: We developed an automated retrieval and analysis system fo... Read More about INfrastructure for a PHAge REference Database: Identification of Large-Scale Biases in the Current Collection of Cultured Phage Genomes.

Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens (2021)
Journal Article
Cook, R., Hooton, S., Trivedi, U., King, L., Dodd, C. E., Hobman, J. L., Stekel, D. J., Jones, M. A., & Millard, A. D. (2021). Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens. Microbiome, 9, Article 65. https://doi.org/10.1186/s40168-021-01010-3

Viruses are the most abundant biological entities on Earth, known to be crucial components of microbial ecosystems. However, there is little information on the viral community within agricultural waste. There are currently ~ 2.7 million dairy cattle... Read More about Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens.

A Model to Investigate the Impact of Farm Practice on Antimicrobial Resistance in UK Dairy Farms (2021)
Journal Article
Lanyon, C. W., King, J. R., Stekel, D. J., & Gomes, R. L. (2021). A Model to Investigate the Impact of Farm Practice on Antimicrobial Resistance in UK Dairy Farms. Bulletin of Mathematical Biology, 83(4), Article 36. https://doi.org/10.1007/s11538-021-00865-9

© 2021, The Author(s). The ecological and human health impact of antibiotic use and the related antimicrobial resistance (AMR) in animal husbandry is poorly understood. In many countries, there has been considerable pressure to reduce overall antibio... Read More about A Model to Investigate the Impact of Farm Practice on Antimicrobial Resistance in UK Dairy Farms.

Towards a general model for predicting minimal metal concentrations co-selecting for antibiotic resistance plasmids (2021)
Journal Article
Arya, S., Williams, A., Reina, S. V., Knapp, C. W., Kreft, J.-U., Hobman, J. L., & Stekel, D. J. (2021). Towards a general model for predicting minimal metal concentrations co-selecting for antibiotic resistance plasmids. Environmental Pollution, 275, Article 116602. https://doi.org/10.1016/j.envpol.2021.116602

© 2021 Elsevier Ltd Many antibiotic resistance genes co-occur with resistance genes for transition metals, such as copper, zinc, or mercury. In some environments, a positive correlation between high metal concentration and high abundance of antibioti... Read More about Towards a general model for predicting minimal metal concentrations co-selecting for antibiotic resistance plasmids.