Dr KRISTELLE BROWN's Outputs (2)

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study (2017)
Journal Article
Guerreiro, R., Ross, O. A., Kun-Rodrigues, C., Hernandez, D., Orme, T., Eicher, J. D., Shepherd, C., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Ansorge, O., Clarimon, J., Barber, I. S., Braae, A., Brown, K., & Morgan, K. (2018). Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet Neurology, 17(1), 64-74. https://doi.org/10.1016/S1474-4422%2817%2930400-3

Background Dementia with Lewy bodies is the second most common form of dementia in elderly people but has been overshadowed in the research field, partly because of similarities between dementia with Lewy bodies, Parkinson’s disease, and Alzheimer’s... Read More about Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglialmediated innate immunity in Alzheimer’s disease (2017)
Journal Article
Sims, R., van der Lee, S. J., Naj, A. C., Bellenguez, C., Badarinarayan, N., Jakobsdottir, J., Kunkle, B. W., Boland, A., Raybould, R., Bis, J. C., Martin, E. R., Grenier-Boley, B., Medway, C., Brown, K., Braae, A., Lord, J., Turton, J., Barber, I. S., Brookes, K., & Morgan, K. (in press). Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglialmediated innate immunity in Alzheimer’s disease. Nature Genetics, 49(9), https://doi.org/10.1038/ng.3916

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 ×... Read More about Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglialmediated innate immunity in Alzheimer’s disease.