Professor MOHAMMAD ILYAS's Outputs (4)

High α-SMA expression in the tumor stroma is associated with adverse clinical parameters in mismatch repair–proficient colorectal cancers only (2024)
Journal Article
Sculthorpe, D. J., Denton, A., Fadhil, W., Rusnita, D., Ilyas, M., & Mukherjee, A. (2024). High α-SMA expression in the tumor stroma is associated with adverse clinical parameters in mismatch repair–proficient colorectal cancers only. American Journal of Clinical Pathology, https://doi.org/10.1093/ajcp/aqae145

Objectives
As mismatch repair status confers differential prognosis in colorectal cancers, this study aimed to determine associations of α–smooth muscle actin (α-SMA) protein expression in mismatch repair–proficient (pMMR) and mismatch repair–defici... Read More about High α-SMA expression in the tumor stroma is associated with adverse clinical parameters in mismatch repair–proficient colorectal cancers only.

Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon (2024)
Journal Article
Almozyan, S., Babaei-Jadidi, R., Aljohani, A., Youssefi, S., Dalleywater, W., Kadam, P., Spencer-Dene, B., Rakha, E., Ilyas, M., & Shams Nateri, A. (2025). Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon. Cancer Communications, 45(1), 9-14. https://doi.org/10.1002/cac2.12625

Advantages of automated immunostain analyses for complex membranous immunostains: An exemplar investigating loss of E-cadherin expression in colorectal cancer (2024)
Journal Article
Sculthorpe, D., Denton, A., Rusnita, D., Fadhil, W., Ilyas, M., & Mukherjee, A. (2024). Advantages of automated immunostain analyses for complex membranous immunostains: An exemplar investigating loss of E-cadherin expression in colorectal cancer. Pathology - Research and Practice, 260, Article 155470. https://doi.org/10.1016/j.prp.2024.155470

As pathology moves towards digitisation, biomarker profiling through automated image analysis provides potentially objective and time-efficient means of assessment. This study set out to determine how a complex membranous immunostain, E-cadherin, ass... Read More about Advantages of automated immunostain analyses for complex membranous immunostains: An exemplar investigating loss of E-cadherin expression in colorectal cancer.

Digital pathology for reporting histopathology samples, including cancer screening samples – definitive evidence from a multisite study (2024)
Journal Article
Azam, A. S., Tsang, Y., Thirlwall, J., Kimani, P. K., Sah, S., Gopalakrishnan, K., Boyd, C., Loughrey, M. B., Kelly, P. J., Boyle, D. P., Salto‐Tellez, M., Clark, D., Ellis, I. O., Ilyas, M., Rakha, E., Bickers, A., Roberts, I. S. D., Soares, M. F., Neil, D. A. H., Takyi, A., …Snead, D. R. J. (2024). Digital pathology for reporting histopathology samples, including cancer screening samples – definitive evidence from a multisite study. Histopathology, 84(5), 847-862. https://doi.org/10.1111/his.15129

Aims: To conduct a definitive multicentre comparison of digital pathology (DP) with light microscopy (LM) for reporting histopathology slides including breast and bowel cancer screening samples.
Methods: A total of 2024 cases (608 breast, 607 GI, 6... Read More about Digital pathology for reporting histopathology samples, including cancer screening samples – definitive evidence from a multisite study.