Dr KEITH SPRIGGS's Outputs (2)

Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study (2024)
Journal Article
Lawrence, S., Lin, J., Khurshid, A., Utami, W., Singhania, R., Ashraf, S., Thorn, G. J., Mangangcha, I. R., Spriggs, K., Kim, D., Barrett, D., & de Moor, C. H. (2025). Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study. FEBS Letters, 599(3), 415-435. https://doi.org/10.1002/1873-3468.15046

Cordycepin (3′ deoxyadenosine) has been widely researched as a potential cancer therapy, but many diverse mechanisms of action have been proposed. Here, we confirm that cordycepin triphosphate is likely to be the active metabolite of cordycepin and t... Read More about Cordycepin generally inhibits growth factor signal transduction in a systems pharmacology study.

Antiproliferative activities of some selected Nigerian medicinal plants against breast, liver, and cervical cancer cells (2024)
Journal Article
Olaleye, O. O., Kim, D.-H., & Spriggs, K. A. (2024). Antiproliferative activities of some selected Nigerian medicinal plants against breast, liver, and cervical cancer cells. BMC Complementary Medicine and Therapies, 24(1), Article 110. https://doi.org/10.1186/s12906-024-04365-w

Background: Phytochemicals have become a growing source of alternative medicine in developing countries due to the poor prognosis, high cost of conventional pharmaceuticals, and undesirable effects associated with mainstream cancer treatment. Objecti... Read More about Antiproliferative activities of some selected Nigerian medicinal plants against breast, liver, and cervical cancer cells.