Emergence of airway smooth muscle mechanical behaviour through dynamic reorganisation of contractile units and force transmission pathways
(2014)
Journal Article
Brook, B. S. (2014). Emergence of airway smooth muscle mechanical behaviour through dynamic reorganisation of contractile units and force transmission pathways. Journal of Applied Physiology, 116(8), 980-997. https://doi.org/10.1152/japplphysiol.01209.2013
Professor BINDI BROOK's Outputs (23)
The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model (2014)
Journal Article
Chernyavsky, I. L., Croisier, H., Chapman, L. A., Kimpton, L. S., Hiorns, J. E., Brook, B., Jensen, O. E., Billington, C. K., Hall, I. P., & Johnson, S. R. (2014). The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model. PLoS ONE, 9(3), Article e90162. https://doi.org/10.1371/journal.pone.0090162Despite a large amount of in vitro data, the dynamics of airway smooth muscle (ASM) mass increase in the airways of patients with asthma is not well understood. Here, we present a novel mathematical model that describes qualitatively the growth dynam... Read More about The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model.
Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model (2013)
Journal Article
Croisier, H., Tan, X., Perez-Zoghbi, J. F., Sanderson, M. J., Sneyd, J., & Brook, B. S. (2013). Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model. PLoS ONE, 8(7), Article e69598. https://doi.org/10.1371/journal.pone.0069598Intracellular dynamics of airway smooth muscle cells (ASMC) mediate ASMC contraction and proliferation, and thus play a key role in airway hyper-responsiveness (AHR) and remodelling in asthma. We evaluate the importance of store-operated entry (SOC... Read More about Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model.