Professor TRICIA MCKEEVER's Outputs (8)

Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study (2020)
Journal Article
Siraj, R., McKeever, T., Gibson, J., Gordon, A., & Bolton, C. (2021). Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study. Respiratory Medicine, 177, Article 106288. https://doi.org/10.1016/j.rmed.2020.106288

Background: Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive. Objective: To determine the incidenc... Read More about Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study.

Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study (2020)
Journal Article
Chalitsios, C. V., McKeever, T. M., & Shaw, D. E. (2020). Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study. European Respiratory Journal, 56(Suppl. 64), Article 1427. https://doi.org/10.1183/13993003.congress-2020.1427

Background: Osteoporosis and fragility fractures (FF) are associated with corticosteroids which are the mainstay treatment for asthma; however, these bone comorbidities within asthma need to be better described.

Methods: A matched cohort study was... Read More about Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study.

Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults: a case-control test-negative design study (2020)
Journal Article
Lawrence, H., Pick, H., Baskaran, V., Daniel, P., Rodrigo, C., Ashton, D., Edwards-Pritchard, R. C., Sheppard, C., Eletu, S. D., Litt, D., Fry, N. K., Rose, S., Trotter, C., McKeever, T. M., & Lim, W. S. (2020). Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults: a case-control test-negative design study. PLoS Medicine, 17(10), Article e1003326. https://doi.org/10.1371/journal.pmed.1003326

Background: Vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPV23) is available in the UK to adults aged 65 years or over and those in defined clinical risk groups. We evaluated the vaccine effectiveness (VE) of PPV23 against vac... Read More about Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against vaccine serotype pneumococcal pneumonia in adults: a case-control test-negative design study.

Risk of osteoporosis and fragility fractures in asthma due to oral and inhaled corticosteroids: two population-based nested case-control studies (2020)
Journal Article
Chalitsios, C. V., Shaw, D. E., & McKeever, T. M. (2020). Risk of osteoporosis and fragility fractures in asthma due to oral and inhaled corticosteroids: two population-based nested case-control studies. Thorax, 76(1), 21-28. https://doi.org/10.1136/thoraxjnl-2020-215664

© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. Background Inhaled (ICS) and oral (OCS) corticosteroids are used widely in asthma; however, the risk of osteoporosis and fragility fracture (... Read More about Risk of osteoporosis and fragility fractures in asthma due to oral and inhaled corticosteroids: two population-based nested case-control studies.

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement (2020)
Journal Article
Gupta, A., Jayes, L. R., Holmes, S., Sahota, O., Canavan, M., Elkin, S. L., Lim, K., Murphy, A. C., Singh, S., Towlson, E. A., Ward, H., Scullion, J., McKeever, T. M., & Bolton, C. E. (2020). Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement. International Journal of Chronic Obstructive Pulmonary Disease, 15, 1377-1390. https://doi.org/10.2147/copd.s233398

Introduction: Osteoporosis and bone fractures are common in chronic obstructive pulmonary disease (COPD) and contribute significantly to morbidity and mortality. Current national guidance on COPD management recommends addressing bone health in patien... Read More about Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement.

Phenotypic and functional translation of IL33 genetics in asthma (2020)
Journal Article
Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., Xu, C. J., Hankinson, J., Bhaker, S., Henry, A. P., Billington, C. K., Shaw, D. E., Johnson, S. R., Benest, A., Pang, V., Bates, D. O., Pogson, Z. E., Fogarty, A., McKeever, T. M., Singapuri, A., …Nawijn, M. C. (2021). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, 147(1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051

© 2020 Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevate... Read More about Phenotypic and functional translation of IL33 genetics in asthma.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., Grotenboer, N. S., Obeidat, M., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Pogson, Z. E., Fogarty, A., McKeever, T. M., Nickle, D. C., Bossé, Y., van den Berge, M., Faiz, A., Brouwer, S., …Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8), Article 132446. https://doi.org/10.1172/jci.insight.132446

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.

A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England (2020)
Journal Article
Chalitsios, C. V., Shaw, D. E., & McKeever, T. M. (2020). A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England. npj Primary Care Respiratory Medicine, 30(1), Article 5. https://doi.org/10.1038/s41533-020-0162-6

© 2020, The Author(s). Exposure to oral corticosteroids (OCS) is associated with an increased risk of osteoporosis and fragility fractures. Guidelines suggest bisphosphonate (BP) therapy as the first-line treatment of glucocorticoid-induced osteoporo... Read More about A retrospective database study of oral corticosteroid and bisphosphonate prescribing patterns in England.