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Dr IAN MELLOR's Outputs (3)

Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity (2020)
Journal Article
Fazel, M. F., Abu, I. F., Mohamad, M. H. N., Agarwal, R., Iezhitsa, I., Bakar, N. S., Juliana, N., Mellor, I. R., & Franzyk, H. (2020). Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity. PLoS ONE, 15(7), Article e0236450. https://doi.org/10.1371/journal.pone.0236450

Retinal ganglion cell (RGC) loss and optic neuropathy, both hallmarks of glaucoma, have been shown to involve N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity. This study investigated the neuroprotective effects of Philanthotoxin (PhTX)-... Read More about Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity.

The effects of knock-down resistance mutations and alternative splicing on voltage-gated sodium channels in Musca domestica and Drosophila melanogaster (2020)
Journal Article
Thompson, A. J., Verdin, P. S., Burton, M. J., Davies, T. G., Williamson, M. S., Field, L. M., Baines, R. A., Mellor, I. R., & Duce, I. R. (2020). The effects of knock-down resistance mutations and alternative splicing on voltage-gated sodium channels in Musca domestica and Drosophila melanogaster. Insect Biochemistry and Molecular Biology, 122, Article 103388. https://doi.org/10.1016/j.ibmb.2020.103388

© 2020 Elsevier Ltd Voltage-gated sodium channels (VGSCs) are a major target site for the action of pyrethroid insecticides and resistance to pyrethroids has been ascribed to mutations in the VGSC gene. VGSCs in insects are encoded by only one gene a... Read More about The effects of knock-down resistance mutations and alternative splicing on voltage-gated sodium channels in Musca domestica and Drosophila melanogaster.

Actions on mammalian and insect nicotinic acetylcholine receptors of harmonine-containing alkaloid extracts from the harlequin ladybird Harmonia axyridis (2020)
Journal Article
Patel, R. N., Richards, D. P., Duce, I. R., Birkett, M. A., Sattelle, D. B., & Mellor, I. R. (2020). Actions on mammalian and insect nicotinic acetylcholine receptors of harmonine-containing alkaloid extracts from the harlequin ladybird Harmonia axyridis. Pesticide Biochemistry and Physiology, 166, Article 104561. https://doi.org/10.1016/j.pestbp.2020.104561

© 2020 Elsevier Inc. The harlequin ladybird, Harmonia axyridis (H. axyridis), possesses a strong chemical defence that has contributed to its invasive success. Ladybird beetle defensive chemicals, secreted in response to stress and also found on the... Read More about Actions on mammalian and insect nicotinic acetylcholine receptors of harmonine-containing alkaloid extracts from the harlequin ladybird Harmonia axyridis.