IAN MELLOR's Outputs (4)

Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities (2019)
Journal Article
Koromina, M., Flitton, M., Blockley, A., Mellor, I. R., & Knight, H. (2019). Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities. Scientific Reports, 9, Article 19215. https://doi.org/10.1038/s41598-019-55635-4

Schizophrenia (Scz), autism spectrum disorder (ASD) and intellectual disability are common complex neurodevelopmental disorders. Kainate receptors (KARs) are ionotropic glutamate ion channels involved in synaptic plasticity which are modulated by aux... Read More about Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities.

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals (2019)
Journal Article
Casewell, N. R., Petras, D., Card, D. C., Suranse, V., Mychajliw, A. M., Richards, D., …Turvey, S. T. (2019). Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals. Proceedings of the National Academy of Sciences, 116(51), 25745–25755. https://doi.org/10.1073/pnas.1906117116

Venom systems are key adaptations that have evolved throughout the tree of life and typically facilitate predation or defense. Despite venoms being model systems for studying a variety of evolutionary and physiological processes, many taxonomic group... Read More about Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals.

Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease (2019)
Journal Article
Rosini, M., Simoni, E., Caporaso, R., Basagni, F., Catanzaro, M., Abu, I. F., …Minarini, A. (2019). Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease. European Journal of Medicinal Chemistry, 180, 111-120. https://doi.org/10.1016/j.ejmech.2019.07.011

N-methyl-d-aspartate receptors (NMDAR) are critically involved in the pathogenesis of Alzheimer's disease (AD). Acting as an open-channel blocker, the anti-AD drug memantine preferentially targets NMDAR overactivation, which has been proposed to trig... Read More about Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease.

Philanthotoxin analogues that selectively inhibit ganglionic nicotinic acetylcholine receptors with exceptional potency (2019)
Journal Article
Kachel, H. S., Franzyk, H., & Mellor, I. R. (2019). Philanthotoxin analogues that selectively inhibit ganglionic nicotinic acetylcholine receptors with exceptional potency. Journal of Medicinal Chemistry, 62(13), 6214-6222. https://doi.org/10.1021/acs.jmedchem.9b00519

Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 non-selectively inhibits several excitatory ligand-gated ion channels, and we recently showed that its synthetic analogue... Read More about Philanthotoxin analogues that selectively inhibit ganglionic nicotinic acetylcholine receptors with exceptional potency.