Bridging the gap: bitopic ligands of G-protein-coupled receptors
(2012)
Journal Article
Lane, J. R., Sexton, P. M., & Christopoulos, A. (2013). Bridging the gap: bitopic ligands of G-protein-coupled receptors. Trends in Pharmacological Sciences, 34(1), 59-66. https://doi.org/10.1016/j.tips.2012.10.003
Although classical approaches to G-protein-coupled receptor (GPCR) drug design have targeted the orthosteric binding site, potentially all GPCRs possess druggable allosteric sites. In addition, it is clear that GPCRs can adopt multiple active states... Read More about Bridging the gap: bitopic ligands of G-protein-coupled receptors.