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Theoretical Study on the Biosynthesis of the Mandapamates: Mechanistic Insights Using Density Functional Theory (2024)
Journal Article
Wang, D., Pattenden, G., Fow, K. L., Stocks, M. J., Hirst, J. D., & Tang, B. (2024). Theoretical Study on the Biosynthesis of the Mandapamates: Mechanistic Insights Using Density Functional Theory. Journal of Organic Chemistry, https://doi.org/10.1021/acs.joc.4c00859

Density functional theory (B3LYP-D3(BJ) and ωB97XD) calculations have been used to assess the stereochemical outcomes of the proposed transannular [4 + 2] cycloaddition pathway for the biosynthesis of mandapamate and isomandapamate from macrocyclic i... Read More about Theoretical Study on the Biosynthesis of the Mandapamates: Mechanistic Insights Using Density Functional Theory.

Exploring general practitioners’ management of self-harm in young people: a qualitative study (2024)
Journal Article
Mughal, F., Saunders, B., Lewis, M., Armitage, C., Dikomitis, L., Lancaster, G., Townsend, E., & Chew-Graham, C. A. (2024). Exploring general practitioners’ management of self-harm in young people: a qualitative study. Health Expectations, 27(5), Article e70026. https://doi.org/10.1111/hex.70026

Background
General practitioners (GPs) are key to the frontline assessment and treatment of young people after self-harm. Young people value GP-led self-harm care but little is known about how GPs manage young people after self-harm.

Aim
To und... Read More about Exploring general practitioners’ management of self-harm in young people: a qualitative study.

Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies (2024)
Journal Article
Jensen, M. D., West, J., Crooks, C., Morling, J. R., Kraglund, F., Card, T., Askgaard, G., & Jepsen, P. (2024). Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies. American Journal of Gastroenterology, https://doi.org/10.14309/ajg.0000000000003077

Background & Aims:

Patients with alcohol-related cirrhosis (ALD cirrhosis) have an increased risk of primary liver cancer (hepatocellular carcinoma [HCC] or intrahepatic cholangiocarcinoma [iCCA]). England recommends surveillance for HCC in these... Read More about Primary liver cancer risk and mortality in patients with alcohol-related cirrhosis in England and Denmark: observational cohort studies.

Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial (2024)
Journal Article
Harris, V., Holmes, J., Gbinigie, O., Rahman, N. M., Richards, D. B., Hayward, G., Dorward, J., Lowe, D. M., Standing, J. F., Breuer, J., Khoo, S., Petrou, S., Hood, K., Ahmed, H., Carson-Stevens, A., Nguyen-Van-Tam, J. S., Patel, M. G., Saville, B. R., Francis, N., Thomas, N. P. B., …Butler, C. C. (2024). Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial. Lancet Infectious Diseases, https://doi.org/10.1016/S1473-3099%2824%2900431-6

Background
No randomised controlled trials have yet reported on the effectiveness of molnupiravir on longer term outcomes for COVID-19. The PANORAMIC trial found molnupiravir reduced time to recovery in acute COVID-19 over 28 days. We aimed to repor... Read More about Health outcomes 3 months and 6 months after molnupiravir treatment for COVID-19 for people at higher risk in the community (PANORAMIC): a randomised controlled trial.

Cannabidiol and fluorinated derivative anti-cancer properties against glioblastoma multiforme cell lines, and synergy with imidazotetrazine agents (2024)
Journal Article
Brookes, A., Kindon, N., Scurr, D. J., Alexander, M. R., Gershkovich, P., & Bradshaw, T. (2024). Cannabidiol and fluorinated derivative anti-cancer properties against glioblastoma multiforme cell lines, and synergy with imidazotetrazine agents. BJC Reports, 2, Article 67. https://doi.org/10.1038/s44276-024-00088-0

Background
Glioblastoma multiforme (GBM) is an aggressive cancer with poor prognosis, partly due to resistance to the standard chemotherapy treatment, temozolomide (TMZ). Phytocannabinoid cannabidiol (CBD) has exhibited anti-cancer effects against G... Read More about Cannabidiol and fluorinated derivative anti-cancer properties against glioblastoma multiforme cell lines, and synergy with imidazotetrazine agents.

Paving the road while walking -perspectives from Flexible Assertive Community Treatment managers on preparing the implementation of peer support work in Outpatient Services (2024)
Journal Article
Johansen, K. K., Lerbaek, B., Slade, M., Castelein, S., & Jørgensen, R. (2024). Paving the road while walking -perspectives from Flexible Assertive Community Treatment managers on preparing the implementation of peer support work in Outpatient Services. Issues in Mental Health Nursing, https://doi.org/10.1080/01612840.2024.2391848

This qualitative study explored the perspectives of Flexible Assertive Community Treatment managers on preparation and employment of peer support workers. The study was based on semi-structured interviews with managers (n = 5) in Outpatient Services... Read More about Paving the road while walking -perspectives from Flexible Assertive Community Treatment managers on preparing the implementation of peer support work in Outpatient Services.

Research into digital health intervention for mental health: a 25-year retrospective on the ethical and legal challenges (2024)
Journal Article
Hall, C. L., Gómez Bergin, A. D., & Rennick-Egglestone, S. (2024). Research into digital health intervention for mental health: a 25-year retrospective on the ethical and legal challenges. Journal of Medical Internet Research, 26, Article e58939. https://doi.org/10.2196/58939

Digital mental health interventions are routinely integrated into mental health services internationally, and can contribute to the reduction of the global mental health treatment gap that has been identified by the World Health Organisation. Researc... Read More about Research into digital health intervention for mental health: a 25-year retrospective on the ethical and legal challenges.

Parenting in a changing climate: the relationship between talking to children aged 5-11 about climate change, family eco-behaviours and climate change anxiety (2024)
Journal Article
Jackson, J., Rawson, R., Colman, R., Kotero, Y., & Brooks-Ucheaga, M. (2024). Parenting in a changing climate: the relationship between talking to children aged 5-11 about climate change, family eco-behaviours and climate change anxiety. Global Health Economics and Sustainability, 2(3), Article 3172. https://doi.org/10.36922/ghes.3172

Climate change has a substantial impact on human health and the increased symptoms of climate change anxiety have led to a global call for action. However, data exploring the relationship between climate change, mental health, and individuals with pa... Read More about Parenting in a changing climate: the relationship between talking to children aged 5-11 about climate change, family eco-behaviours and climate change anxiety.

Not always as advertised: Different effects from viewing safer gambling (harm prevention) adverts on gambling urges (2024)
Journal Article
Newall, P., Weiss-Cohen, L., Torrance, J., & Bart, Y. (2025). Not always as advertised: Different effects from viewing safer gambling (harm prevention) adverts on gambling urges. Addictive Behaviors, 160, Article 108161. https://doi.org/10.1016/j.addbeh.2024.108161

Public concern around gambling advertising in the UK has been met not by government action but by industry self-regulations, such as a forthcoming voluntary ban on front-of-shirt gambling sponsorship in Premier League soccer. “Safer gambling” (harm p... Read More about Not always as advertised: Different effects from viewing safer gambling (harm prevention) adverts on gambling urges.

Engaging low-income families in education research: examining the challenges in Beijing and London (2024)
Journal Article
Hoskins, K., Wainwright, E., Arabaci, R., Zhai, J., Gao, J., & XU, Y. (in press). Engaging low-income families in education research: examining the challenges in Beijing and London. Compare: A Journal of Comparative and International Education,

This comparative paper considers the similar challenges encountered in Beijing (China) and Greater London (England) when engaging low-income families in education research. Through semi-structured interviews with 10 parents/caregivers in Beijing and... Read More about Engaging low-income families in education research: examining the challenges in Beijing and London.

The Memory in Return Volatility: An Analysis of Mutual Fund Returns (2024)
Journal Article
Yao, K., Duan, K., Huang, R., & Chevapatrakul, T. (in press). The Memory in Return Volatility: An Analysis of Mutual Fund Returns. International Journal of Finance and Economics,

This paper examines long memory in the return volatility in the cross-section of U.S. mutual funds. Our results provide evidence of this phenomenon. Through univariate analysis, we find that the long memory in mutual fund return volatility is more pr... Read More about The Memory in Return Volatility: An Analysis of Mutual Fund Returns.

LES informed data-driven models for RANS simulations of single-hole cooling flows (2024)
Journal Article
Ellis, C. D., & Xia, H. (2024). LES informed data-driven models for RANS simulations of single-hole cooling flows. International Journal of Heat and Mass Transfer, 235, Article 126150. https://doi.org/10.1016/j.ijheatmasstransfer.2024.126150

A LES-informed data-driven approach for improved predictions of the turbulent heat flux vector has been sought for film and effusion cooling flow applications. Random forest and shallow neural networks have been used to train a spatially varying coef... Read More about LES informed data-driven models for RANS simulations of single-hole cooling flows.

Using online methods to recruit participants into mental health clinical trials: considerations and recommendations from the RE-MIND study (2024)
Journal Article
Iflaifel, M., Hall, C. L., Green, H. R., Willis, A., Rennick-Egglestone, S., Juszczak, E., Townsend, M., Martin, J., & Sprange, K. (2024). Using online methods to recruit participants into mental health clinical trials: considerations and recommendations from the RE-MIND study. Trials, 25, Article 596. https://doi.org/10.1186/s13063-024-08435-9

Background: Ensuring diversity in clinical trials can be a challenge, which may be exacerbated when recruiting vulnerable populations, such as participants with mental health illness. As recruitment continues to be the major cause of trial delays, re... Read More about Using online methods to recruit participants into mental health clinical trials: considerations and recommendations from the RE-MIND study.

To cut or not to cut: Deforestation policy under the shadow of foreign influence (2024)
Journal Article
Aidt, T. S., Albornoz, F., & Hauk, E. (2024). To cut or not to cut: Deforestation policy under the shadow of foreign influence. Journal of Economic Behavior and Organization, 227, Article 106712

This article explores the complex interplay between deforestation policies and foreign influence, using a game theoretical model to analyze geopolitical factors influencing forest conservation decisions in countries with significant rainforests. The... Read More about To cut or not to cut: Deforestation policy under the shadow of foreign influence.

Endovascular Thrombectomy vs Best Medical Management for Late Presentation Acute Ischaemic Stroke with Large Vessel Occlusion Without CT Perfusion or MR Imaging Selection: A Systematic Review and Meta-Analysis (2024)
Journal Article
Dhillon, P. S., Marei, O., Podlasek, A., Butt, W., Rice, H., de Villiers, L., Carraro do Nascimento, V., McConachie, N., Lenthall, R., Nair, S., Malik, L., Bhogal, P., Dineen, R. A., & England, T. J. (2024). Endovascular Thrombectomy vs Best Medical Management for Late Presentation Acute Ischaemic Stroke with Large Vessel Occlusion Without CT Perfusion or MR Imaging Selection: A Systematic Review and Meta-Analysis. Journal of Stroke and Cerebrovascular Diseases,

Background: The efficacy and safety of endovascular thrombectomy (EVT) beyond 6 hours from stroke onset for patients with large vessel occlusion (LVO) selected without CT perfusion(CTP) or MR imaging(MRI) is undetermined. We conducted a systematic re... Read More about Endovascular Thrombectomy vs Best Medical Management for Late Presentation Acute Ischaemic Stroke with Large Vessel Occlusion Without CT Perfusion or MR Imaging Selection: A Systematic Review and Meta-Analysis.

Assembly of the Intracluster Light in the Horizon-AGN Simulation (2024)
Journal Article
Brown, H. J., Martin, G., Pearce, F. R., Hatch, N. A., Bahé, Y. M., & Dubois, Y. (2024). Assembly of the Intracluster Light in the Horizon-AGN Simulation. Monthly Notices of the Royal Astronomical Society, https://doi.org/10.1093/mnras/stae2084

The diffuse stellar component of galaxy clusters made up of intergalactic stars is termed the intracluster light (ICL). Though there is a developing understanding of the mechanisms by which the ICL is formed, no strong consensus has yet been reached... Read More about Assembly of the Intracluster Light in the Horizon-AGN Simulation.

PDI-Functionalized Glass Beads: Efficient, Metal-Free Heterogeneous Photocatalysts Suitable for Flow Photochemistry (2024)
Journal Article
Ali, H., Ahmed, I., Robertson, K., & Lanterna, A. E. (2024). PDI-Functionalized Glass Beads: Efficient, Metal-Free Heterogeneous Photocatalysts Suitable for Flow Photochemistry. Organic Process Research and Development, https://doi.org/10.1021/acs.oprd.4c00256

Perylene diimides (PDI) have an extraordinary ability to activate both energy and electron transfer processes upon light excitation; however, their extremely low solubility has hindered their wide use as photocatalysts. Here, we show that the combina... Read More about PDI-Functionalized Glass Beads: Efficient, Metal-Free Heterogeneous Photocatalysts Suitable for Flow Photochemistry.

Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis (2024)
Journal Article
Mu, G., Peng, F., Zhang, Z., M. Brameld, J., Rose, P., Yang, X., Jiang, Z.-J., He, X., & Tang, B. (2024). Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis. Journal of Drug Delivery Science and Technology, 101(Part A), Article 106151. https://doi.org/10.1016/j.jddst.2024.106151

This study designed and developed a novel three-layer electrostatic, slow-releasing nanoparticle drug delivery system for the treatment of ulcerative colitis. The nanoparticles were composed of layers of zein-based polydopamine, chitosan and cellulos... Read More about Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis.