Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland

Dhillo, W. S.; Small, C. J.; Gardiner, J. V.; Bewick, G. A.; Whitworth, E. J.; Jethwa, P. H.; Seal, L. J.; Ghatei, M. A.; Hinson, J. P.; Bloom, S. R.

doi:10.1016/S0006-291X(02)02991-1

All Outputs (46017)

Inflammation and angiogenesis in osteoarthritis (2003)
Journal Article
Haywood, L., McWilliams, D. F., Pearson, C. I., Gill, S. E., Ganesan, A., Wilson, D., & Walsh, D. A. (2003). Inflammation and angiogenesis in osteoarthritis. Arthritis and Rheumatism, 48(8), 2173-2177. https://doi.org/10.1002/art.11094

Objective. To quantify the relationship between inflammation and angiogenesis in synovial tissue from patients with osteoarthritis (OA). Methods. Hematoxylin and eosin staining and histologic grading for inflammation were performed for 104 patients w... Read More about Inflammation and angiogenesis in osteoarthritis.

Using Action Research to Enhance Teaching and Learning at the University of Technology, Jamaica (2003)
Journal Article
George, N. A., Craven, M., Williams-Meyers, C., & Bonnick, P. (2003). Using Action Research to Enhance Teaching and Learning at the University of Technology, Jamaica. Assessment and Evaluation in Higher Education, 28(3), 239-250. doi:10.1080/0260293032000059603

As part of its quality assurance systems, the University of Technology, Jamaica initiated a project aimed at exploring how action research could be used as a vehicle for enhancing the quality of the teaching/learning process. Following a series of or... Read More about Using Action Research to Enhance Teaching and Learning at the University of Technology, Jamaica.

Der neue historische Afrika-Roman: Kolonialismus aus postkolonialer Sicht (2003)
Journal Article
Göttsche, D. (2003). Der neue historische Afrika-Roman: Kolonialismus aus postkolonialer Sicht. German Life and Letters, 56(3), https://doi.org/10.1111/1468-0483.00256

Im Rahmen des sprunghaft angestiegenen Interesses an Afrika in der deutschsprachigen Literatur der Jahrtausendwende sind seit Uwe Timms Morenga (1978) neue historische Afrika-Romane entstanden, die die Erinnerung an den vergessenen deutschen Anteil a... Read More about Der neue historische Afrika-Roman: Kolonialismus aus postkolonialer Sicht.

The transcriptional repressor protein PRH interacts with the proteasome (2003)
Journal Article
Bess, K. L., Swingler, T. E., Rivett, A. J., Gaston, K., & Jayaraman, P. (2003). The transcriptional repressor protein PRH interacts with the proteasome. Biochemical Journal, 374(3), 667-675. https://doi.org/10.1042/BJ20030769

PRH (proline-rich homeodomain protein)/Hex is important in the control of cell proliferation and differentiation. We have shown previously that PRH contains two domains that can bring about transcriptional repression independently; the PRH homeodomai... Read More about The transcriptional repressor protein PRH interacts with the proteasome.

Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system (2003)
Journal Article
Scott, R. J., Lian, L. Y., Muharram, S. H., Cockayne, A., Wood, S. J., Bycroft, B. W., …Chan, W. C. (2003). Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system. Bioorganic and Medicinal Chemistry Letters, 13(15), 2449-2453. https://doi.org/10.1016/S0960-894X%2803%2900497-9

The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is activated in response to a secreted autoinducer peptide (AIP). By exploiting the unique chemical a... Read More about Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system.

Chasing the genes that control resistance to gastrointestinal nematodes (2003)
Journal Article
Behnke, J. M., Iraqi, F., Menge, D., Baker, R., Gibson, J., & Wakelin, D. (2003). Chasing the genes that control resistance to gastrointestinal nematodes. Journal of Helminthology, 77(2), https://doi.org/10.1079/JOH2003174

The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite’s antigens and culminate in an inflammatory reaction in the intestinal mucosa.... Read More about Chasing the genes that control resistance to gastrointestinal nematodes.

The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype (2003)
Journal Article
Ben-Smith, A., Lammas, D., & Behnke, J. M. (2003). The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype. Journal of Helminthology, 77(2), https://doi.org/10.1079/JOH2003173

T helper cell (Th1 and Th2) associated responses were examined following a primary infection with the gastrointestinal nematode Heligmosomoides polygyrus in five inbred strains of mice with different resistance phenotypes. Levels of (i) mast cell pro... Read More about The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype.

Seasonal distribution of genetic types of planktonic foraminifer morphospecies in the Santa Barbara channel and its paleoceanographic implications (2003)
Journal Article
Darling, K. F., Kucera, M., Wade, C. M., von Langen, P., & Pak, D. (2003). Seasonal distribution of genetic types of planktonic foraminifer morphospecies in the Santa Barbara channel and its paleoceanographic implications. Paleoceanography, 18(2), Article 1032. https://doi.org/10.1029/2001pa000723

We present data on the temporal distribution of planktonic foraminifer genotypes (small subunit (SSU) ribosomal (r) RNA gene) and morphospecies (sediment traps) collected during 1999 in the Santa Barbara Channel. The sampling was undertaken with spec... Read More about Seasonal distribution of genetic types of planktonic foraminifer morphospecies in the Santa Barbara channel and its paleoceanographic implications.

Caregiver strain in spouses of stroke patients (2003)
Journal Article
Blake, H., Lincoln, N. B., & Clarke, D. D. (2003). Caregiver strain in spouses of stroke patients. Clinical Rehabilitation, 17(3), 312-317. https://doi.org/10.1191/0269215503cr613oa

Objective: To test the ability of a previously generated logistic regression model to predict caregiver strain from carer mood, negative affectivity and perceived patient functional ability.

Design: Postal prospective survey.

Setting: Spouses o... Read More about Caregiver strain in spouses of stroke patients.

Transcriptional repression in eukaryotes: repressors and repression mechanisms (2003)
Journal Article
Gaston, K., & Jayaraman, P. (2003). Transcriptional repression in eukaryotes: repressors and repression mechanisms. Cellular and Molecular Life Sciences, 60(4), 721-741. https://doi.org/10.1007/s00018-003-2260-3

For many, if not most genes, the initiation of transcription is the principle point at which their expression is regulated. Transcription factors, some of which bind to specific DNA sequences, generally either activate or repress promoter activity an... Read More about Transcriptional repression in eukaryotes: repressors and repression mechanisms.

Fuzzy Recognition of Cricket Batting Strokes Based on Sequences of Body and Bat Postures (2003)
Presentation / Conference Contribution
Kelly, M., Curtis, K. M., & Craven, M. (2003). Fuzzy Recognition of Cricket Batting Strokes Based on Sequences of Body and Bat Postures. In Proceedings. IEEE SoutheastCon, 2003 - Bridging the digital divide. https://doi.org/10.1109/SECON.2003.1268444

A mathematical classification of two cricket batting strokes, using fuzzy set theory, is presented. A system is proposed within this paper, to capture the motion of a batsman/batswoman whilst playing a stroke. This is then compared to known strokes,... Read More about Fuzzy Recognition of Cricket Batting Strokes Based on Sequences of Body and Bat Postures.

The Truro cordwainers' play: a "new" 18th century Christmas play (2003)
Journal Article
Millington, P. (2003). The Truro cordwainers' play: a "new" 18th century Christmas play. Folklore, 114(1), https://doi.org/10.1080/0015587032000059870

The Christmas play hitherto attributed to Mylor has been re-ascribed to Truro in the late 1780s, using biographical information concerning the actors, and physical characteristics of the manuscript. It becomes the oldest Saint George play to feature... Read More about The Truro cordwainers' play: a "new" 18th century Christmas play.

Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis (2003)
Journal Article
Dhillo, W. S., Small, C. J., Jethwa, P. H., Russell, S. H., Gardiner, J. V., Bewick, G. A., …Bloom, S. R. (2003). Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis. Endocrinology, 144(4), 1420-1425. https://doi.org/10.1210/en.2002-220902

Calcitonin gene-related protein (CGRP) inhibits food intake and stimulates the hypothalamo-pituitary-adrenal (HPA) axis after intracerebroventricular injection in rats. However, the hypothalamic site and mechanism of action are unknown. We investigat... Read More about Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis.

Geographical inequalities in lung cancer management and survival in South East England: Evidence of variation in access to oncology services? (2003)
Journal Article
Jack, R. H., Gulliford, M. C., Ferguson, J., & Møller, H. (2003). Geographical inequalities in lung cancer management and survival in South East England: Evidence of variation in access to oncology services?. British Journal of Cancer, 88(7), 1025-1031. https://doi.org/10.1038/sj.bjc.6600831

This study aimed to determine whether the management and survival of patients with lung cancer varied among 26 health authorities in South East England. The Thames Cancer Registry identified patients diagnosed with lung cancer (ICD-10 codes C33-C34)... Read More about Geographical inequalities in lung cancer management and survival in South East England: Evidence of variation in access to oncology services?.

Resistance to spontaneous apoptosis in acute myeloid leukaemia blasts is associated with p-glycoprotein expression and function, but not with the presence of FLT3 internal tandem duplications (2003)
Journal Article
Pallis, M., Turzanski, J., Grundy, M., Seedhouse, C., & Russell, N. (2003). Resistance to spontaneous apoptosis in acute myeloid leukaemia blasts is associated with p-glycoprotein expression and function, but not with the presence of FLT3 internal tandem duplications. British Journal of Haematology, 120(6), 1009-1016. https://doi.org/10.1046/j.1365-2141.2003.04210.x

The ability of acute myeloid leukaemia (AML) blasts to survive in culture has been associated with poor patient response to chemotherapy. Other biological factors predicting an adverse outcome include p-glycoprotein (pgp) expression, which is associa... Read More about Resistance to spontaneous apoptosis in acute myeloid leukaemia blasts is associated with p-glycoprotein expression and function, but not with the presence of FLT3 internal tandem duplications.

Liposome entrapment and immunogenic studies of a synthetic lipophilic multiple antigenic peptide bearing VP1 and VP3 domains of the hepatitis A virus: A robust method for vaccine design (2003)
Journal Article
Haro, I., Pérez, S., García, M., Chan, W. C., & Ercilla, G. (2003). Liposome entrapment and immunogenic studies of a synthetic lipophilic multiple antigenic peptide bearing VP1 and VP3 domains of the hepatitis A virus: A robust method for vaccine design. FEBS Letters, 540(1-3), 133-140. https://doi.org/10.1016/S0014-5793%2803%2900249-7

Multiple antigen peptides (MAP) have been demonstrated to be efficient immunological reagents for the induction of immune responses to a variety of infectious agents. Several peptide domains of the hepatitis A virus (HAV) capsid proteins, mainly VP1... Read More about Liposome entrapment and immunogenic studies of a synthetic lipophilic multiple antigenic peptide bearing VP1 and VP3 domains of the hepatitis A virus: A robust method for vaccine design.

Flow cytometric measurement of phosphorylated STAT5 in AML: Lack of specific association with FLT3 internal tandem duplications (2003)
Journal Article
Pallis, M., Seedhouse, C., Grundy, M., & Russell, N. (2003). Flow cytometric measurement of phosphorylated STAT5 in AML: Lack of specific association with FLT3 internal tandem duplications. Leukemia Research, 27(9), 803-805. https://doi.org/10.1016/S0145-2126%2803%2900012-2

STAT5 phosphorylation has been noted in 69–95% of AML cases by Western blotting. We used flow cytometry to measure phosphorylated STAT5 on a semi-quantitative scale. The method was validated on K562 cells, which constitutively express phosphorylated... Read More about Flow cytometric measurement of phosphorylated STAT5 in AML: Lack of specific association with FLT3 internal tandem duplications.

Landau-Gutzwiller quasi-particles (2003)
Journal Article
Bünemann, J., Gebhard, F., & Thul, R. (2003). Landau-Gutzwiller quasi-particles. Physical Review B, 67, Article 075103. https://doi.org/10.1103/PhysRevB.67.075103

We deﬁne Landau quasiparticles within the Gutzwiller variational theory and derive their dispersion relation for general multiband Hubbard models in the limit of large spatial dimensions D. Thereby we reproduce our previous calculations which were ba... Read More about Landau-Gutzwiller quasi-particles.

An extensible event-based infrastructure for networked virtual worlds (2003)
Journal Article
Purbrick, J., & Greenhalgh, C. (2003). An extensible event-based infrastructure for networked virtual worlds. Presence: Teleoperators and Virtual Environments, 12(1), 68–84. https://doi.org/10.1162/105474603763835341

Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland (2003)
Journal Article
Dhillo, W. S., Small, C. J., Gardiner, J. V., Bewick, G. A., Whitworth, E. J., Jethwa, P. H., …Bloom, S. R. (2003). Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Biochemical and Biophysical Research Communications, 301(1), 102-107. https://doi.org/10.1016/S0006-291X%2802%2902991-1

α-Melanocyte-stimulating-hormone (α-MSH) is an agonist at the melanocortin 3 receptor (MC3-R) and melanocortin 4 receptor (MC4-R). α-MSH stimulates corticosterone release from rat adrenal glomerulosa cells in vitro. Agouti-related protein (AgRP) an e... Read More about Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland.