All Outputs (3916)

Adaptive Testing for Cointegration With Nonstationary Volatility (2021)
Journal Article
Boswijk, H. P., & Zu, Y. (2022). Adaptive Testing for Cointegration With Nonstationary Volatility. Journal of Business and Economic Statistics, 40(2), 744-755. https://doi.org/10.1080/07350015.2020.1867558

This article develops a class of adaptive cointegration tests for multivariate time series with nonstationary volatility. Persistent changes in the innovation variance matrix of a vector autoregressive model lead to size distortions in conventional c... Read More about Adaptive Testing for Cointegration With Nonstationary Volatility.

Simulating the effect of fabric bending stiffness on the wrinkling behaviour of biaxial fabrics during preforming (2021)
Journal Article
Yu, F., Chen, S., Harper, L., & Warrior, N. (2021). Simulating the effect of fabric bending stiffness on the wrinkling behaviour of biaxial fabrics during preforming. Composites Part A: Applied Science and Manufacturing, 143, Article 106308. https://doi.org/10.1016/j.compositesa.2021.106308

A macroscopic finite element model has been established to investigate the forming-induced wrinkling behaviour for bi-axial fabrics. Results indicate that using a linear bending model with a constant bending stiffness produces unrealistic wrinkle pat... Read More about Simulating the effect of fabric bending stiffness on the wrinkling behaviour of biaxial fabrics during preforming.

From Cow Manure to Bioactive Carbon Dots: A Light-up Probe for Bioimaging Investigations, Glucose Detection and Potential Immunotherapy Agent for Melanoma Skin Cancer (2021)
Journal Article
Hillesheim Horst, F., Vitoria da Silva Rodrigues, C., Pimenta Rocha Carvalho, P. H., Monteiro Leite, A., Bentes Azevedo, R., Neto, B. A., …Rodrigues, M. O. (2021). From Cow Manure to Bioactive Carbon Dots: A Light-up Probe for Bioimaging Investigations, Glucose Detection and Potential Immunotherapy Agent for Melanoma Skin Cancer. RSC Advances, 2021(11), 6346-6352. https://doi.org/10.1039/D0RA10859F

Bioactive carbon dots (C-dots) with ca. 4 nm were successfully produced with singular photophysical properties, low-toxicity and interesting immunological response. The optical properties of the C-dots were investigated and the “light-up” behaviour e... Read More about From Cow Manure to Bioactive Carbon Dots: A Light-up Probe for Bioimaging Investigations, Glucose Detection and Potential Immunotherapy Agent for Melanoma Skin Cancer.

Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation (2021)
Journal Article
Stolady, D., Laviola, M., Pillai, A., & Hardman, J. G. (2021). Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation. British Journal of Anaesthesia, 126(4), 889-895. https://doi.org/10.1016/j.bja.2020.12.031

Background

Studies of pulmonary denitrogenation (pre-oxygenation) in obstetric populations have shown high flow nasal oxygen therapy (HFNO) is inferior to facemask techniques. HFNO achieves median end-tidal oxygen fraction (FE′O2) of 0.87 after 3... Read More about Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation.

Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres (2021)
Journal Article
Wallace, M. N., Sumner, C. J., Berger, J. I., McNaughton, P. A., & Palmer, A. R. (2021). Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres. Neuroscience Letters, 747, Article 135705. https://doi.org/10.1016/j.neulet.2021.135705

Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in... Read More about Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres.

Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse (2021)
Journal Article
Jia, T., Xie, C., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., …IMAGEN Consortium. (2021). Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse. Science Advances, 7(6), 1-10. https://doi.org/10.1126/sciadv.abd4074

Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to charac... Read More about Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse.

Priorities for social science and humanities research on the challenges of moving beyond animal-based food systems (2021)
Journal Article
Morris, C., Kaljonen, M., Aavik, K., Balázs, B., Cole, M., Coles, B., …White, R. (2021). Priorities for social science and humanities research on the challenges of moving beyond animal-based food systems. Humanities and Social Sciences Communications, 8, Article 38. https://doi.org/10.1057/s41599-021-00714-z

Increasingly high-profile research is being undertaken into the socio-environmental challenges associated with the over-production and consumption of food from animals. Transforming food systems to mitigate climate change and hidden hunger, ensure fo... Read More about Priorities for social science and humanities research on the challenges of moving beyond animal-based food systems.

Multiseriate cortical sclerenchyma enhance root penetration in compacted soils (2021)
Journal Article
Schneider, H. M., Strock, C. F., Hanlon, M. T., Vanhees, D. J., Perkins, A. C., Ajmera, I. B., …Lynch, J. P. (2021). Multiseriate cortical sclerenchyma enhance root penetration in compacted soils. Proceedings of the National Academy of Sciences, 118(6), Article e2012087118. https://doi.org/10.1073/pnas.2012087118

Mechanical impedance limits soil exploration and resource capture by plant roots. We examine the role of root anatomy in regulating plant adaptation to mechanical impedance and identify a root anatomical phene in maize (Zea mays) and wheat (Triticum... Read More about Multiseriate cortical sclerenchyma enhance root penetration in compacted soils.

Mindfulness ‘in’ Education as a form of Iatrogenesis (2021)
Journal Article
Brito, R., Joseph, S., & Sellman, E. (2021). Mindfulness ‘in’ Education as a form of Iatrogenesis. Journal of Transformative Education, 19(3), 261-283. https://doi.org/10.1177/1541344620987231

Mindfulness-based Interventions (MBIs) can result in positive ‘side-effects’, such as concentration and individual well-being, highly desirable to schools operating within a neoliberalist agenda emphasizing performativity. However, employing a critic... Read More about Mindfulness ‘in’ Education as a form of Iatrogenesis.

‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study (2021)
Journal Article
Orton, E., Audsley, S., Coupland, C., Gladman, J. R., Iliffe, S., Lafond, N., …Kendrick, D. (2021). ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study. Age and Ageing, 50(4), 1290-1297. https://doi.org/10.1093/ageing/afaa288

Background
Falls incidence increases with age alongside declines in strength and balance. Clinical trials show that the Falls Management Exercise (FaME) programme improves strength and balance, which can reduce falls and improve physical functioning... Read More about ‘Real world’ effectiveness of the Falls Management Exercise (FaME) programme: an implementation study.

Promoting physical activity in primary care: a systematic review and meta-analysis (2021)
Journal Article
Van der Wardt, V., Di Lorito, C., & Viniol, A. (2021). Promoting physical activity in primary care: a systematic review and meta-analysis. British Journal of General Practice, 71(706), e399-e405. https://doi.org/10.3399/bjgp.2020.0817

Background: Promoting physical activity is an important part of patient care in primary care and has been investigated in many studies with a wide range of intervention characteristics often including external support. It is unclear, however, if prom... Read More about Promoting physical activity in primary care: a systematic review and meta-analysis.

Love, Fear and Disgust: Deconstructing Masculinities and Affective Embodiment in Pregnancy Guides for Men (2021)
Journal Article
Edgley, A., & Roberts, J. (2021). Love, Fear and Disgust: Deconstructing Masculinities and Affective Embodiment in Pregnancy Guides for Men. Men and Masculinities, 24(4), 652-670. https://doi.org/10.1177/1097184X21990711

© The Author(s) 2021. Employing a material discursive approach, this article deconstructs advice within published guides to pregnancy and birth written by men for men. We deconstruct the representation of feelings and emotions in men during this peri... Read More about Love, Fear and Disgust: Deconstructing Masculinities and Affective Embodiment in Pregnancy Guides for Men.

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study (2021)
Journal Article
Sebastian, S., Walker, G. J., Kennedy, N. A., Conley, T. E., Patel, K. V., Subramanian, S., …Zafar, M. (2021). Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study. Lancet Gastroenterology and Hepatology, 6(4), 271-281. https://doi.org/10.1016/s2468-1253%2821%2900016-9

Background
There is a paucity of evidence to support safe and effective management of patients with acute severe ulcerative colitis during the COVID-19 pandemic. We sought to identify alterations to established conventional evidence-based management... Read More about Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2021)
Journal Article
Abaleke, E., Abbas, M., Abbasi, S., Abbott, A., Abdelaziz, A., Abdelbadiee, S., …Zuriaga-Alvaro, A. (2021). Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet, 397(10274), 605-612. https://doi.org/10.1016/s0140-6736%2821%2900149-5

Summary
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory
actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.

Methods In t... Read More about Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

International perceptions of urban blue-green infrastructure: A comparison across four cities (2021)
Journal Article
O’Donnell, E. C., Netusil, N. R., Chan, F. K. S., Dolman, N. J., & Gosling, S. N. (2021). International perceptions of urban blue-green infrastructure: A comparison across four cities. Water, 13(4), Article 544. https://doi.org/10.3390/w13040544

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Blue-Green infrastructure (BGI) is recognised internationally as an approach for managing urban water challenges while enhancing society and the environment through the provision of multiple c... Read More about International perceptions of urban blue-green infrastructure: A comparison across four cities.

Immunity in space: prokaryote adaptations and immune response in microgravity (2021)
Journal Article
Green, M. J., Aylott, J. W., Williams, P., Ghaemmaghami, A. M., & Williams, P. M. (2021). Immunity in space: prokaryote adaptations and immune response in microgravity. Life, 11(2), Article 112. https://doi.org/10.3390/life11020112

Immune dysfunction has long been reported by medical professionals regarding astronauts suffering from opportunistic infections both during their time in space and a short period afterwards once back on Earth. Various species of prokaryotes onboard t... Read More about Immunity in space: prokaryote adaptations and immune response in microgravity.

Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents (2021)
Journal Article
Shao, H., Foley, D. W., Huang, S., Abbas, A. Y., Lam, F., Gershkovich, P., …Wang, S. (2021). Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents. European Journal of Medicinal Chemistry, 214, Article 113244. https://doi.org/10.1016/j.ejmech.2021.113244

Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the... Read More about Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents.

A bioinspired humanoid foot mechanism (2021)
Journal Article
Russo, M., Chaparro-Rico, B. D. M., Pavone, L., Pasqua, G., & Cafolla, D. (2021). A bioinspired humanoid foot mechanism. Applied Sciences, 11(4), Article 1686. https://doi.org/10.3390/app11041686

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This paper introduces an innovative robotic foot design inspired by the functionality and the anatomy of the human foot. Most humanoid robots are characterized by flat, rigid feet with limited... Read More about A bioinspired humanoid foot mechanism.

Coordinated prefrontal state transition leads extinction of reward-seeking behaviors (2021)
Journal Article
Russo, E., Ma, T., Spanagel, R., Durstewitz, D., Toutounji, H., & Köhr, G. (2021). Coordinated prefrontal state transition leads extinction of reward-seeking behaviors. Journal of Neuroscience, 41(11), 2406-2419. https://doi.org/10.1523/jneurosci.2588-20.2021

Extinction learning suppresses conditioned reward responses and is thus fundamental to adapt to changing environmental demands and to control excessive reward seeking. The medial prefrontal cortex (mPFC) monitors and controls conditioned reward respo... Read More about Coordinated prefrontal state transition leads extinction of reward-seeking behaviors.

The acceptability to women of techniques for managing an impacted fetal head at caesarean section and of randomised trials evaluating those techniques: a qualitative study (2021)
Journal Article
Romano, G., Mitchell, E., Plachcinski, R., Wakefield, N., Walker, K., & Ayers, S. (2021). The acceptability to women of techniques for managing an impacted fetal head at caesarean section and of randomised trials evaluating those techniques: a qualitative study. BMC Pregnancy and Childbirth, 21, Article 103. https://doi.org/10.1186/s12884-021-03577-z

Background
This study aimed to explore women’s views on the acceptability of different techniques for managing an impacted fetal head at caesarean; and the feasibility and acceptability of conducting a trial in this area.

Methods
Qualitative sem... Read More about The acceptability to women of techniques for managing an impacted fetal head at caesarean section and of randomised trials evaluating those techniques: a qualitative study.