All Outputs (4349)

Female job satisfaction: can we explain the part-time puzzle? (2016)
Journal Article
Bridges, S., & Owens, T. (2017). Female job satisfaction: can we explain the part-time puzzle?. Oxford Economic Papers, 69(3), 782-808. https://doi.org/10.1093/oep/gpw064

Although it is generally accepted that women who work part-time are, on average, more satisfied in their jobs than their full-time counterparts, this is unlikely to be true for all women. Using the British Household Panel Survey we estimate the deter... Read More about Female job satisfaction: can we explain the part-time puzzle?.

The role of apolipoprotein N-acyl transferase, Lnt, in the lipidation of factor H binding protein of Neisseria meningitidis strain MC58 and its potential as a drug target (2016)
Journal Article
da Silva, R., Churchward, C., Karlyshev, A., Eleftheriadou, O., Snabaitis, A., Longman, M., Ryan, A., & Griffin, R. (2017). The role of apolipoprotein N-acyl transferase, Lnt, in the lipidation of factor H binding protein of Neisseria meningitidis strain MC58 and its potential as a drug target. British Journal of Pharmacology, 174(14), 2247-2260. https://doi.org/10.1111/bph.13660

BACKGROUND AND PURPOSE

The level of cell surface expression of the meningococcal vaccine antigen, Factor H binding protein (FHbp) varies between and within strains and this limits the breadth of strains that can be targeted by FHbp-based vaccines.... Read More about The role of apolipoprotein N-acyl transferase, Lnt, in the lipidation of factor H binding protein of Neisseria meningitidis strain MC58 and its potential as a drug target.

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile (2016)
Journal Article
van Eijk, E., Paschalis, V., Green, M., Friggen, A. H., Larson, M. A., Spriggs, K., Briggs, G. S., Soultanas, P., & Smits, W. K. (2016). Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile. Open Biology, 6(12), Article 160272. https://doi.org/10.1098/rsob.160272

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of D... Read More about Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile.

Improving the care of people with dementia in general hospitals: evaluation of a whole-system train the trainer model (2016)
Journal Article
Sampson, E. L., Vickerstaff, V., Lietz, S., & Orrell, M. (in press). Improving the care of people with dementia in general hospitals: evaluation of a whole-system train the trainer model. International Psychogeriatrics, 29(4), https://doi.org/10.1017/S1041610216002222

Background: There are concerns about the quality of care that people with dementia receive in the general hospital. Staff report a lack of confidence and inadequate training in dementia care.
Methods: A train-the-trainer model was implemented across... Read More about Improving the care of people with dementia in general hospitals: evaluation of a whole-system train the trainer model.

Fast and exact Newton and bidirectional fitting of Active Appearance Models (2016)
Journal Article
Kossaifi, J., Tzimiropoulos, G., & Pantic, M. (2017). Fast and exact Newton and bidirectional fitting of Active Appearance Models. IEEE Transactions on Image Processing, 26(2), 1040 - 1053. https://doi.org/10.1109/TIP.2016.2642828

Active Appearance Models (AAMs) are generative models of shape and appearance that have proven very attractive for their ability to handle wide changes in illumination, pose and occlusion when trained in the wild, while not requiring large training d... Read More about Fast and exact Newton and bidirectional fitting of Active Appearance Models.

Electromagnetic heating for industrial kilning of malt: a feasibility study (2016)
Journal Article
Ferrari-John, R., Katrib, J., Zerva, E., Davies, N., Cook, D. J., Dodds, C., & Kingman, S. (in press). Electromagnetic heating for industrial kilning of malt: a feasibility study. Food and Bioprocess Technology, https://doi.org/10.1007/s11947-016-1849-0

Industrial malting operations use ~800kWh/t of energy to produce the heat required to kiln malt. Electromagnetic heating technologies are suggested as a way to potentially improve the energy efficiency of the kilning processing. In this work, the pot... Read More about Electromagnetic heating for industrial kilning of malt: a feasibility study.

A novel approach to design lesion-specific stents for minimum recoil (2016)
Journal Article
Farhan Khan, M., Brackett, D., Ashcroft, I., Tuck, C., & Wildman, R. D. (in press). A novel approach to design lesion-specific stents for minimum recoil. Journal of Medical Devices, 11(1), Article 011001. https://doi.org/10.1115/1.4034880

Stent geometries are obtained by topology optimization for minimized compliance under different stenosis levels and plaque material types. Three levels of stenosis by cross-sectional area, i.e., 30%, 40%, and 50% and three different plaque material p... Read More about A novel approach to design lesion-specific stents for minimum recoil.

Meta-analysis of operative experiences of general surgery trainees during training (2016)
Journal Article
Elsey, E., Griffiths, G., Humes, D., & West, J. (in press). Meta-analysis of operative experiences of general surgery trainees during training. British Journal of Surgery, 104(1), https://doi.org/10.1002/bjs.10396

BACKGROUND: General surgical training curricula around the world set defined operative numbers to be achieved before completion of training. However, there are few studies reporting total operative experience in training. This systematic review aimed... Read More about Meta-analysis of operative experiences of general surgery trainees during training.

Political connections, bailout in financial markets and firm value (2016)
Journal Article
Banerji, S., Duygun, M., & Shaban, M. (2018). Political connections, bailout in financial markets and firm value. Journal of Corporate Finance, 50, 388-401. https://doi.org/10.1016/j.jcorpfin.2016.12.001

The paper shows that politically motivated interventions in the financial market in the form of bailing out borrowing firms reduce banks’ incentives to gather valuable information about firms’ projects. This loss of information is a hidden cost which... Read More about Political connections, bailout in financial markets and firm value.

Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction (2016)
Journal Article
Tubby, C., Negm, O. H., Harrison, T. W., Tighe, P. J., Todd, I., & Fairclough, L. C. (2017). Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction. Journal of Asthma, 54(5), 456-466. https://doi.org/10.1080/02770903.2016.1236941

Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obs... Read More about Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction.

Creating AI Characters for Fighting Games Using Genetic Programming (2016)
Journal Article
Martinez-Arellano, G., Cant, R., & Woods, D. (2017). Creating AI Characters for Fighting Games Using Genetic Programming. IEEE Transactions on Computational Intelligence and AI in Games, 9(4), 423-434. https://doi.org/10.1109/tciaig.2016.2642158

This paper proposes a character generation approach for the M.U.G.E.N. fighting game that can create engaging AI characters using a computationally cheap process without the intervention of the expert developer. The approach uses a genetic programmin... Read More about Creating AI Characters for Fighting Games Using Genetic Programming.

Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy (2016)
Journal Article
Wallace, G., Cro, S., Doré, C., King, L., Kluzek, S., Price, A., Roemer, F., Guermazi, A., Keen, R., & Arden, N. (2017). Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy. Arthritis Care and Research, 69(9), 1340-1348. https://doi.org/10.1002/acr.23162

Objective

Painful knee osteoarthritis (KOA) has been associated with joint inflammation. There is, however, little literature correlating signs of localized inflammation with contrast‐enhanced (CE) magnetic resonance imaging (MRI) of synovium. Thi... Read More about Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy.

Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop (2016)
Journal Article
Borkar, A. N., Vallurupalli, P., Camilloni, C., Kay, L. E., & Vendruscolo, M. (2017). Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop. Physical Chemistry Chemical Physics, 19(4), 2797-2804. https://doi.org/10.1039/c6cp08313g

© the Owner Societies 2017. RNA molecules in solution tend to undergo structural fluctuations of relatively large amplitude and to populate a range of different conformations some of which with low populations. It is still very challenging, however,... Read More about Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop.

Adaptivity and Blow-Up Detection for Nonlinear Evolution Problems (2016)
Journal Article
Cangiani, A., Georgoulis, E. H., Kyza, I., & Metcalfe, S. (2016). Adaptivity and Blow-Up Detection for Nonlinear Evolution Problems. SIAM Journal on Scientific Computing, 38(6), A3833-A3856. https://doi.org/10.1137/16m106073x

This work is concerned with the development of a space-time adaptive numerical method, based on a rigorous a posteriori error bound, for a semilinear convection-diffusion problem which may exhibit blow-up in finite time. More specifically, a posterio... Read More about Adaptivity and Blow-Up Detection for Nonlinear Evolution Problems.

Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis (2016)
Journal Article
Müller, C. P., Kalinichenko, L. S., Tiesel, J., Witt, M., Stöckl, T., Sprenger, E., Fuchser, J., Beckmann, J., Praetner, M., Huber, S. E., Amato, D., Mühle, C., Büttner, C., Ekici, A. B., Smaga, I., Pomierny-Chamiolo, L., Pomierny, B., Filip, M., Eulenburg, V., Gulbins, E., …Kornhuber, J. (2017). Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis. Acta Neuropathologica, 133(3), 463-483. https://doi.org/10.1007/s00401-016-1658-6

Adverse events after first, single, mesh and non-mesh surgical procedures for stress urinary incontinence and pelvic organ prolapse in Scotland, 1997–2016: a population-based cohort study (2016)
Journal Article
Morling, J. R., McAllister, D. A., Agur, W., Fischbacher, C. M., Glazener, C. M., Guerrero, K., Hopkins, L., & Wood, R. (2017). Adverse events after first, single, mesh and non-mesh surgical procedures for stress urinary incontinence and pelvic organ prolapse in Scotland, 1997–2016: a population-based cohort study. Lancet, 389(10069), 629-640. https://doi.org/10.1016/S0140-6736%2816%2932572-7

Background

Concerns have been raised about the safety of surgery for stress urinary incontinence and pelvic organ prolapse using transvaginal mesh. We assessed adverse outcomes after first, single mesh procedures and comparable non-mesh procedures... Read More about Adverse events after first, single, mesh and non-mesh surgical procedures for stress urinary incontinence and pelvic organ prolapse in Scotland, 1997–2016: a population-based cohort study.

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus (2016)
Journal Article
Zapotoczna, M., Murray, E. J., Hogan, S., O'Gara, J. P., Chhabra, S. R., Chan, W. C., O'Neill, E., & Williams, P. (2017). 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 72(3), 744-753. https://doi.org/10.1093/jac/dkw482

Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential of 5-hydroxyethyl-3-tetradec... Read More about 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.

Which traits do observers use to distinguish Batesian mimics from their models? (2016)
Journal Article
Taylor, C. H., Warrin, J., Gilbert, F., & Reader, T. (in press). Which traits do observers use to distinguish Batesian mimics from their models?. Behavioral Ecology, 28(2), https://doi.org/10.1093/beheco/arw166

Batesian mimicry, in which a harmless mimic resembles a more aversive model, can encompass a wide range of morphological traits, but the resemblance is never perfect. Previous studies have used abstract “prey” designs to show that differences in cert... Read More about Which traits do observers use to distinguish Batesian mimics from their models?.

Validation of a quantifier-based fuzzy classification system for breast cancer patients on external independent cohorts (2016)
Presentation / Conference Contribution
Soria, D., & Garibaldi, J. M. Validation of a quantifier-based fuzzy classification system for breast cancer patients on external independent cohorts. Presented at International Conference on Machine Learning and Applications

Recent studies in breast cancer domains have identified seven distinct clinical phenotypes (groups) using immunohistochemical analysis and a variety of unsupervised learning techniques. Consensus among the clustering algorithms has been used to categ... Read More about Validation of a quantifier-based fuzzy classification system for breast cancer patients on external independent cohorts.

High resolution 3D imaging of living cells with sub-optical wavelength phonons (2016)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Marques, L., Webb, K. F., & Clark, M. (2016). High resolution 3D imaging of living cells with sub-optical wavelength phonons. Scientific Reports, 6, Article 39326. https://doi.org/10.1038/srep39326

Label-free imaging of living cells below the optical diffraction limit poses great challenges for optical microscopy. Biologically relevant structural information remains below the Rayleigh limit and beyond the reach of conventional microscopes. Supe... Read More about High resolution 3D imaging of living cells with sub-optical wavelength phonons.