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Heuristic generation via parameter tuning for online bin packing (2015)
Presentation / Conference Contribution
Yarimcam, A., Asta, S., Ozcan, E., & Parkes, A. J. (2015). Heuristic generation via parameter tuning for online bin packing. In 2014 IEEE Symposium on Evolving and Autonomous Learning Systems (EALS) (102-108). https://doi.org/10.1109/EALS.2014.7009510

© 2014 IEEE. Online bin packing requires immediate decisions to be made for placing an incoming item one at a time into bins of fixed capacity without causing any overflow. The goal is to maximise the average bin fullness after placement of a long st... Read More about Heuristic generation via parameter tuning for online bin packing.

Segalen et l'Autre impossible (2015)
Book Chapter
Ridon, J. (2015). Segalen et l'Autre impossible. In Exotisme et Altérité, Segalen et la Polynésie (81-97). Paris: Honoré Champion

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration (2015)
Journal Article
Peretti, D., Bastide, A., Radford, H., Verity, N., Molloy, C., Martin, M. G., …Mallucci, G. R. (2015). RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration. Nature, 518(7538), 236-239. https://doi.org/10.1038/nature14142

In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity1. Reduction in synapse number is a consistent early feature of neurodegenerative diseases2,3, suggesting def... Read More about RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.

The performance of US equity mutual funds (2015)
Journal Article
Babalos, V., Mamatzakis, E. C., & Matousek, R. (2015). The performance of US equity mutual funds. Journal of Banking and Finance, 52, 217-229. https://doi.org/10.1016/j.jbankfin.2014.12.008

The paper examines the performance of US no-load equity mutual funds. Fund performance is derived using stochastic frontier analysis for a flexible functional form. This analysis allows us to derive paramet-ric estimates of efficiency scores for each... Read More about The performance of US equity mutual funds.

Making Sense of Self-Employment in Late Career: Understanding the Identity Work of Olderpreneurs (2015)
Journal Article
Mallett, O., & Wapshott, R. (2015). Making Sense of Self-Employment in Late Career: Understanding the Identity Work of Olderpreneurs. Work, Employment and Society, 29(2), 250-266. https://doi.org/10.1177/0950017014546666

The enterprise culture is a pervasive socio-historical discourse. This article adopts a narrative identity work approach to explore how individuals may exert agency to make sense of and negotiate with the structuring features of such discourses. Olde... Read More about Making Sense of Self-Employment in Late Career: Understanding the Identity Work of Olderpreneurs.

‘Social Services will not touch us with a barge pole’: social care provision for older prisoners (2015)
Journal Article
O’Hara, K., Forsyth, K., Senior, J., Stevenson, C., Hayes, A., Challis, D., & Shaw, J. (2015). ‘Social Services will not touch us with a barge pole’: social care provision for older prisoners. Journal of Forensic Psychiatry and Psychology, 26(2), 275-281. https://doi.org/10.1080/14789949.2014.1000938

© 2015 Taylor & Francis. Older prisoners are the fastest growing subgroup in the English and Welsh prison estate. Older prisoners have high levels of health and social care needs. This mixed-method study involved the distribution of a questionnaire... Read More about ‘Social Services will not touch us with a barge pole’: social care provision for older prisoners.

Interventions to reduce dependency in personal activities of daily living in community dwelling adults who use homecare services: a systematic review (2015)
Journal Article
Whitehead, P. J., Worthington, E., Parry, R. H., Walker, M. F., & Drummond, A. E. (2015). Interventions to reduce dependency in personal activities of daily living in community dwelling adults who use homecare services: a systematic review. Clinical Rehabilitation, 29(11), https://doi.org/10.1177/0269215514564894

Objectives: To identify interventions that aim to reduce dependency in activities of daily living (ADL) in homecare service users. To determine: content; effectiveness in improving ability to perform ADL; and whether delivery by qualified occupationa... Read More about Interventions to reduce dependency in personal activities of daily living in community dwelling adults who use homecare services: a systematic review.

Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold (2015)
Journal Article
Schwehm, C., Li, J., Song, H., Hu, X., Kellam, B., & Stocks, M. (2015). Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold. ACS Medicinal Chemistry Letters, 6(3), https://doi.org/10.1021/ml500503n

A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compoun... Read More about Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold.

Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry (2015)
Journal Article
Nortcliffe, A., & Moody, C. J. (2015). Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry. Bioorganic and Medicinal Chemistry, 23(11), 2730-2735. https://doi.org/10.1016/j.bmc.2015.01.010

© 2015 Elsevier Ltd. All rights reserved. Functionalised azepane and oxepane scaffolds were prepared using diazocarbonyl chemistry and elaborated to show their potential use in library synthesis. Key dicarbonyl containing seven-membered rings were fu... Read More about Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry.

A phase 3, open-label, randomized trial to evaluate the safety and efficacy of levofloxacin inhalation solution (APT-1026) versus tobramycin inhalation solution in stable cystic fibrosis patients (2015)
Journal Article
Elborn, J. S., Geller, D. E., Conrad, D., Aaron, S. D., Smyth, A. R., Fischer, R., …Flume, P. (2015). A phase 3, open-label, randomized trial to evaluate the safety and efficacy of levofloxacin inhalation solution (APT-1026) versus tobramycin inhalation solution in stable cystic fibrosis patients. Journal of Cystic Fibrosis, 14(4), https://doi.org/10.1016/j.jcf.2014.12.013

Background: Inhaled antibiotics are standard of care for persons with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa airway infection. APT-1026 (levofloxacin inhalation solution, LIS) is fluoroquinolone in development. We compared the safe... Read More about A phase 3, open-label, randomized trial to evaluate the safety and efficacy of levofloxacin inhalation solution (APT-1026) versus tobramycin inhalation solution in stable cystic fibrosis patients.

A cluster randomised feasibility trial evaluating six-month nutritional interventions in the treatment of malnutrition in care home-dwelling adults: recruitment, data collection and protocol (2015)
Journal Article
Stow, R., Rushton, A., Ives, N., Smith, C., & Rick, C. (2015). A cluster randomised feasibility trial evaluating six-month nutritional interventions in the treatment of malnutrition in care home-dwelling adults: recruitment, data collection and protocol. Pilot and Feasibility Studies, 1(3), https://doi.org/10.1186/2055-5784-1-3

Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation (2015)
Journal Article

Introduction: Direct comparison of the relative efficacy of different recruitment maneuvers (RMs) for patients with acute respiratory distress syndrome (ARDS) via clinical trials is difficult, due to the heterogeneity of patient populations and disea... Read More about Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation.

In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment (2015)
Journal Article
Ivanova, D. P., Parker, T. L., Walker, D. A., Alexander, C., Ashford, M. B., Gellert, P. R., & Garnett, M. C. (2015). In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment. Journal of Biotechnology, 205, 3-13. https://doi.org/10.1016/j.jbiotec.2015.01.002

Physiologically relevant in vitro models can serve as biological analytical platforms for testing novel treatments and drug delivery systems. We describe the first steps in the development of a 3D human brain tumour co-culture model that includes the... Read More about In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment.

Rating the UK: the British government's sovereign credit ratings, 1976–8 (2015)
Journal Article
Gill, D. J. (2015). Rating the UK: the British government's sovereign credit ratings, 1976–8. Economic History Review, 68(3), 1016-1037. https://doi.org/10.1111/ehr.12095

The UK received its first sovereign credit ratings in 1978. Despite having required financial assistance from the International Monetary Fund only 18 months earlier, the British government managed to secure ‘triple-A’ ratings from both Standard and P... Read More about Rating the UK: the British government's sovereign credit ratings, 1976–8.

Gordon Valentine Manley and his contribution to the study of climate change: a review of his life and work (2015)
Journal Article
Endfield, G. H., Veale, L., & Hall, A. (2015). Gordon Valentine Manley and his contribution to the study of climate change: a review of his life and work. Wiley Interdisciplinary Reviews: Climate Change, https://doi.org/10.1002/wcc.334

British climatologist and geographer, Gordon Manley (1902–1980), is perhaps best known for his pioneering work on climate variability in the UK, for establishing the Central England Temperature series and, for his pivotal role in demonstrating the po... Read More about Gordon Valentine Manley and his contribution to the study of climate change: a review of his life and work.

Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection (2015)
Journal Article
Darch, S. E., McNally, A., Harrison, F., Corander, J., Barr, H. L., Paszkiewicz, K., …Diggle, S. P. (2015). Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Scientific Reports, 5, Article 7649. https://doi.org/10.1038/srep07649

The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly resistant to multiple antibiotics. Here, we investigate the phenotypic and genotyp... Read More about Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection.

Decreased photosynthesis in the erect panicle 3 (ep3) mutant of rice is associated with reduced stomatal conductance and attenuated guard cell development (2015)
Journal Article
Yu, H., Murchie, E. H., Gonzalez-Carranza, Z. H., Pyke, K. A., & Roberts, J. A. (2015). Decreased photosynthesis in the erect panicle 3 (ep3) mutant of rice is associated with reduced stomatal conductance and attenuated guard cell development. Journal of Experimental Botany, 66(5), 1543-1552. https://doi.org/10.1093/jxb/eru525

The ERECT PANICLE 3 gene of rice encodes a peptide that exhibits more than 50% sequence identity with the Arabidopsis F-box protein HAWAIIAN SKIRT (HWS). Ectopic expression of the Os02g15950 coding sequence, driven by the HWS (At3g61950) promoter, re... Read More about Decreased photosynthesis in the erect panicle 3 (ep3) mutant of rice is associated with reduced stomatal conductance and attenuated guard cell development.