Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold

Schwehm, Carolin; Li, Jin; Song, Hongmei; Hu, Xiao; Kellam, Barrie; Stocks, Michael

Abstract

A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown.

Citation

Schwehm, C., Li, J., Song, H., Hu, X., Kellam, B., & Stocks, M. (2015). Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold. ACS Medicinal Chemistry Letters, 6(3), https://doi.org/10.1021/ml500503n

• Journal Article Type: Article
• Publication Date: Jan 13, 2015
• Deposit Date: Mar 12, 2015
• Publicly Available Date: Mar 12, 2015
• Journal: ACS Medicinal Chemistry Letters
• Electronic ISSN: 1948-5875
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 3
• DOI: https://doi.org/10.1021/ml500503n
• Keywords: Diabetes, Scaffold, Crystal Structure, Dipeptyl Peptidase VI (DPP-4) Inhibitor, 1,2,4-Triazole
• Public URL: https://nottingham-repository.worktribe.com/output/743385
• Publisher URL: http://pubs.acs.org/doi/abs/10.1021/ml500503n
• Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Medicinal Chemistry Letters, copyright © American Chemical Society after peer review and technical editing by the publisher.; To access the final edited and published work see: http://pubs.acs.org/doi/abs/10.1021/ml500503n