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Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold

Schwehm, Carolin; Li, Jin; Song, Hongmei; Hu, Xiao; Kellam, Barrie; Stocks, Michael

Authors

Carolin Schwehm paxcs4@exmail.nottingham.ac.uk

Jin Li

Hongmei Song

Xiao Hu

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BARRIE KELLAM BARRIE.KELLAM@NOTTINGHAM.AC.UK
Professor of Medicinal Chemistry

MICHAEL STOCKS MICHAEL.STOCKS@NOTTINGHAM.AC.UK
Professor of Medicinal Chemistryand Drug Discovery



Abstract

A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown.

Journal Article Type Article
Publication Date Jan 13, 2015
Journal ACS Medicinal Chemistry Letters
Print ISSN 1948-5875
Electronic ISSN 1948-5875
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 6
Issue 3
APA6 Citation Schwehm, C., Li, J., Song, H., Hu, X., Kellam, B., & Stocks, M. (2015). Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold. ACS Medicinal Chemistry Letters, 6(3), doi:10.1021/ml500503n
DOI https://doi.org/10.1021/ml500503n
Keywords Diabetes, Scaffold, Crystal Structure, Dipeptyl Peptidase VI (DPP-4) Inhibitor, 1,2,4-Triazole
Publisher URL http://pubs.acs.org/doi/abs/10.1021/ml500503n
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Medicinal Chemistry Letters, copyright © American Chemical Society after peer review and technical editing by the publisher.
To access the final edited and published work see: http://pubs.acs.org/doi/abs/10.1021/ml500503n

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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