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Self-tuning and the derivation of a class of scalar-tensor theories (2012)
Journal Article
Charmousis, C., Copeland, E. J., Padilla, A., & Saffin, P. M. (2012). Self-tuning and the derivation of a class of scalar-tensor theories. Physical Review D, 85(10), Article 104040. https://doi.org/10.1103/PhysRevD.85.104040

We have recently proposed a special class of scalar tensor theories known as the Fab Four. These arose from attempts to analyse the cosmological constant problem within the context of Horndeski's most general scalar tensor theory. The Fab Four togeth... Read More about Self-tuning and the derivation of a class of scalar-tensor theories.

A prospective cross-screening study on G-protein-coupled receptors: lessons learned in virtual compound library design. (2012)
Journal Article
Sanders, M. P. A., Roumen, L., van der Horst, E., Lane, J. R., Vischer, H. F., van Offenbeek, J., de Vries, H., Verhoeven, S., Chow, K. Y., Verkaar, F., Beukers, M. W., McGuire, R., Leurs, R., Ijzerman, A. P., de Vlieg, J., de Esch, I. J. P., Zaman, G. J. R., Klomp, J. P. G., Bender, A., & de Graaf, C. (2012). A prospective cross-screening study on G-protein-coupled receptors: lessons learned in virtual compound library design. Journal of Medicinal Chemistry, 55(11), 5311-5325. https://doi.org/10.1021/jm300280e

We present the systematic prospective evaluation of a protein-based and a ligand-based virtual screening platform against a set of three G-protein-coupled receptors (GPCRs): the β-2 adrenoreceptor (ADRB2), the adenosine A(2A) receptor (AA2AR), and th... Read More about A prospective cross-screening study on G-protein-coupled receptors: lessons learned in virtual compound library design..

Strategies for MCR image analysis of large hyperspectral data-sets (2012)
Journal Article
Scurr, D. J., Hook, A. L., Burley, J., Williams, P. M., Anderson, D. G., Langer, R., …Alexander, M. R. (2012). Strategies for MCR image analysis of large hyperspectral data-sets. Surface and Interface Analysis, 45(1), https://doi.org/10.1002/sia.5040

Polymer microarrays are a key enabling technology for high throughput materials discovery. In this study, multivariate image analysis, specifically multivariate curve resolution (MCR), is applied to the hyperspectral time of flight secondary ion mass... Read More about Strategies for MCR image analysis of large hyperspectral data-sets.

The Lyman α forest flux probability distribution at z>3 (2012)
Journal Article
Calura, F., Tescari, E., D’Odorico, V., Viel, M., Cristiani, S., Kim, T.-S., & Bolton, J. (2012). The Lyman α forest flux probability distribution at z>3. Monthly Notices of the Royal Astronomical Society, 422(4), 3019-3036. https://doi.org/10.1111/j.1365-2966.2012.20811.x

We present a measurement of the Lyman α flux probability distribution function (PDF) obtained from a set of eight high-resolution quasar spectra with emission redshifts in the range 3.3 ≤z≤ 3.8. We carefully study the effect of metal absorption lines... Read More about The Lyman α forest flux probability distribution at z>3.

Access to antiepileptic drug therapy in children in Camagüey Province, Cuba (2012)
Journal Article
Bárzaga Arencibia, Z., López Leyvac, A., Mejías Peñad, Y., González Reyes, A. R., Acosta Nápolez, M., Carbonell Perdomo, D., …Choonara, I. (2012). Access to antiepileptic drug therapy in children in Camagüey Province, Cuba. International Journal of Pharmacy Practice, 20(6), https://doi.org/10.1111/j.2042-7174.2012.00215.x

Objective  To describe access to antiepileptic drug therapy and estimate the prevalence of epilepsy in children in Camagüey Province, Cuba.

Methods  All the community pharmacies in the province were visited and information collected about the numb... Read More about Access to antiepileptic drug therapy in children in Camagüey Province, Cuba.

Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention (2012)
Journal Article
Morriss, R. K., Kai, J., Atha, C., Avery, A., Bayes, S., Franklin, M., …Yang, M. (2012). Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention. BMC Family Practice, 13(39), https://doi.org/10.1186/1471-2296-13-39

Background:

The top 3% of frequent attendance in primary care is associated with 15% of all appointments in primary care, a fivefold increase in hospital expenditure, and more mental disorder and functional somatic symptoms compared to normal atte... Read More about Persistent frequent attenders in primary care: costs, reasons for attendance, organisation of care and potential for cognitive behavioural therapeutic intervention.

Phytochemical Composition of Oryza sativa (Rice) Bran Oil Bodies in Crude and Purified Isolates (2012)
Journal Article
Nantiyakul, N., Furse, S., Fisk, I., Foster, T. J., Tucker, G., & Gray, D. A. (2012). Phytochemical Composition of Oryza sativa (Rice) Bran Oil Bodies in Crude and Purified Isolates. Journal of the American Oil Chemists' Society, 89(10), 1867-1872. https://doi.org/10.1007/s11746-012-2078-y

We describe a procedure for isolating and purifying oil bodies (OBs) from Oryza sativa bran, and present evidence that strongly suggests a physical association between the OB organelles and several antioxidant phytochemicals (c-oryzanol and several t... Read More about Phytochemical Composition of Oryza sativa (Rice) Bran Oil Bodies in Crude and Purified Isolates.

Delivering Employment Services to Vulnerable Customers: A Case Study of the UK's Employment Service (2012)
Journal Article
Stafford, B., Roberts, S., & Duffy, D. (2012). Delivering Employment Services to Vulnerable Customers: A Case Study of the UK's Employment Service. Social Policy and Society, 11(4), 495-506. https://doi.org/10.1017/S1474746412000206

This article explores the impact of a more individualised public employment service on vulnerable people. It analyses a system Jobcentre Plus implemented in 2008, Accessing Jobcentre Plus Customer Services (AJCS), to improve customer services by mini... Read More about Delivering Employment Services to Vulnerable Customers: A Case Study of the UK's Employment Service.

A moment of transformative learning: creating a disorientating dilemma for a health care student using video feedback (2012)
Journal Article
James, D. M., Collins, L. C., & Samoylova, E. (2012). A moment of transformative learning: creating a disorientating dilemma for a health care student using video feedback. Journal of Transformative Education, 10(4), https://doi.org/10.1177/1541344613480562

This study describes a moment during clinical supervision when a student speech and language therapist reported that she had a moment of illumination that changed her trajectory from failing her clinical placement to passing it. The student’s self-re... Read More about A moment of transformative learning: creating a disorientating dilemma for a health care student using video feedback.

"Vulnerability hotspots": Integrating socio-economic and hydrological models to identify where cereal production may decline in the future due to climate change induced drought (2012)
Journal Article
Fraser, E. D., Simelton, E., Termansen, M., Gosling, S. N., & South, A. (2013). "Vulnerability hotspots": Integrating socio-economic and hydrological models to identify where cereal production may decline in the future due to climate change induced drought. Agricultural and Forest Meteorology, 170, 195-205. https://doi.org/10.1016/j.agrformet.2012.04.008

The purpose of this paper is to identify which of the world's cereal producing regions are likely to become vulnerable to climate change over the 21st century by identifying those regions that will be (1) exposed to climatic stress and (2) have a lim... Read More about "Vulnerability hotspots": Integrating socio-economic and hydrological models to identify where cereal production may decline in the future due to climate change induced drought.

A three-dimensional model of residential energy consumer archetypes for local energy policy design in the UK (2012)
Journal Article
Zhang, T., Siebers, P., & Aickelin, U. (2012). A three-dimensional model of residential energy consumer archetypes for local energy policy design in the UK. Energy Policy, 47, 102-110. https://doi.org/10.1016/j.enpol.2012.04.027

This paper reviews major studies in three traditional lines of research in residential energy consumption in the UK, i.e. economic/infrastructure, behaviour, and load profiling. Based on the review the paper proposes a three-dimensional model for arc... Read More about A three-dimensional model of residential energy consumer archetypes for local energy policy design in the UK.

Sustained translational repression by eIF2α-P mediates prion neurodegeneration (2012)
Journal Article
Moreno, J. A., Radford, H., Peretti, D., Steinert, J. R., Verity, N., Martin, M. G., …Mallucci, G. R. (2012). Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature, 485(7399), 507-511. https://doi.org/10.1038/nature11058

The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer's, Parkinson's and prion diseases, are associated with the accumulation of misfolded disease-specific proteins.... Read More about Sustained translational repression by eIF2α-P mediates prion neurodegeneration.

Genome-wide association study to identify genetic determinants of severe asthma (2012)
Journal Article
Wan, Y., Shrine, N., Soler Artigas, M., Wain, L., Blakey, J., Moffatt, M., …Hall, I. P. (2012). Genome-wide association study to identify genetic determinants of severe asthma. Thorax, 67(9), https://doi.org/10.1136/thoraxjnl-2011-201262

Background The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild to moderate disease and genetic risk factors for severe asthma remain unclear.
Objective To identify co... Read More about Genome-wide association study to identify genetic determinants of severe asthma.

Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study (2012)
Journal Article
McWilliams, D. F., Zhang, W., Mansell, J. S., Kiely, P. D., Young, A., & Walsh, D. A. (2012). Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study. Arthritis Care and Research, 64(10), https://doi.org/10.1002/acr.21723

Objective: To investigate possible predictors for lack of pain improvement after 1 year of treatment for early rheumatoid arthritis (RA).

Methods: The Early Rheumatoid Arthritis Network (ERAN) database was used for analysis of baseline and 1-year... Read More about Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study.

Interface dynamics in planar neural field models (2012)
Journal Article
Coombes, S., Schmidt, H., & Bojak, I. (2012). Interface dynamics in planar neural field models. Journal of Mathematical Neuroscience, 2(1), 1-46. https://doi.org/10.1186/2190-8567-2-9

Neural field models describe the coarse-grained activity of populations of interacting neurons. Because of the laminar structure of real cortical tissue they are often studied in two spatial dimensions, where they are well known to generate rich patt... Read More about Interface dynamics in planar neural field models.

An interpretative phenomenological analysis of the patient experience of awake craniotomy: brain tumour diagnosis to discharge (2012)
Journal Article
Fletcher, K. J., das Nair, R., Macniven, J. A., Basu, S., & Byrne, P. (2012). An interpretative phenomenological analysis of the patient experience of awake craniotomy: brain tumour diagnosis to discharge. British Journal of Health Psychology, 17(4), https://doi.org/10.1111/j.2044-8287.2012.02079.x

Objectives. Previous research exploring the patient experience of awake craniotomy (AC) has yielded contrasting accounts. The current study aimed to explore the lived experience of having undergone an AC in the United Kingdom.

Design. This was a q... Read More about An interpretative phenomenological analysis of the patient experience of awake craniotomy: brain tumour diagnosis to discharge.

Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death (2012)
Journal Article
Rogers, H. A., Kilday, J., Mayne, C., Ward, J., Adamowicz-Brice, M., Schwalbe, E. C., …Grundy, R. G. (2012). Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. Acta Neuropathologica, 123(5), https://doi.org/10.1007/s00401-011-0904-1

Epigenetic alterations, including methylation, have been shown to be an important mechanism of gene silencing in cancer. Ependymoma has been well characterized at the DNA copy number and mRNA expression levels. However little is known about DNA methy... Read More about Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death.